PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19082953-1	2008	Mammalian paraoxonases (PON1, PON2, PON3) are a unique family of calcium-dependent hydrolases, with enzymatic activities toward a broad range of substrates (lactones, thiolactones, carbonates, esters, phosphotriesters).	Lactones	157-165	paraoxonase 3	Homo sapiens	36-40	
35575917-8	2022	Another enzyme associated with HDL is human paraoxonase, calcium-, PON1-, PON2-, and PON3-dependent lactone enzyme with catalytic activity, including reversible binding to substrates.	Lactones	100-107	paraoxonase 3	Homo sapiens	85-89	
31173561-5	2020	Lactone was specifically hydrolyzed by paraoxonase 3 (PON3).5.	Lactones	0-7	paraoxonase 3	Homo sapiens	39-52	
31173561-5	2020	Lactone was specifically hydrolyzed by paraoxonase 3 (PON3).5.	Lactones	0-7	paraoxonase 3	Homo sapiens	54-58	
10931838-6	2000	In contrast to PON1, PON3 has very limited arylesterase and no paraoxonase activities but rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin).	Lactones	109-117	paraoxonase 3	Homo sapiens	21-25	
10931838-8	2000	PON3 hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.	Lactones	25-33	paraoxonase 3	Homo sapiens	0-4	
10931838-8	2000	PON3 hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.	Lactones	58-66	paraoxonase 3	Homo sapiens	0-4	
33562328-1	2021	PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with various substrate specificities.	Lactones	43-50	paraoxonase 3	Homo sapiens	16-20	
30241945-6	2018	Both lactones were very efficiently hydrolyzed by purified PON3.	Lactones	5-13	paraoxonase 3	Homo sapiens	59-63	
30241945-12	2018	The findings provide further insight into the structural requirements for PONs substrates and support the hypothesis that PONs, particularly PON1 and PON3, evolved to hydrolyze and regulate a class of lactone lipid mediators derived from polyunsaturated fatty acids.	Lactones	201-208	paraoxonase 3	Homo sapiens	150-154