PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2612575-1 1989 The administration of GM1 ganglioside, 30 mg/kg per day i.p., begun 3 days prior to an intrastriatal injection of the excitotoxic tryptophan metabolite quinolinic acid (QUIN) and continued for 8-16 days thereafter, significantly decreased QUIN-induced striatal damage, as evaluated by measuring the activity of the marker enzymes, choline acetyltransferase and L-glutamic acid decarboxylase. G(M1) Ganglioside 22-37 choline O-acetyltransferase Rattus norvegicus 331-356 2771061-2 1989 Intraventricular administration of the monosialoganglioside GM1 (5 mg/kg per day), via minipumps, over a period of 14 days prevented this fall in choline acetyltransferase activity. G(M1) Ganglioside 60-63 choline O-acetyltransferase Rattus norvegicus 146-171 2804628-4 1989 In agreement with our previous work, we now provide further evidence that GM1 can prevent shrinkage and the decrease of choline acetyltransferase activity in the nucleus basalis magnocellularis (NBM) of the rat following a unilateral cortical lesion. G(M1) Ganglioside 74-77 choline O-acetyltransferase Rattus norvegicus 120-145 2928318-6 1989 A moderate (up to 35%) stimulation of choline acetyltransferase activity was observed with 10 microM GM1. G(M1) Ganglioside 101-104 choline O-acetyltransferase Rattus norvegicus 38-63 2928318-7 1989 The application of beta-NGF in combination with 10 microM GM1 or 0.1 microM GM1, a concentration that is ineffective in these cultures, produced a much greater increase in choline acetyltransferase activity than did beta-NGF alone. G(M1) Ganglioside 58-61 choline O-acetyltransferase Rattus norvegicus 172-197 2928318-7 1989 The application of beta-NGF in combination with 10 microM GM1 or 0.1 microM GM1, a concentration that is ineffective in these cultures, produced a much greater increase in choline acetyltransferase activity than did beta-NGF alone. G(M1) Ganglioside 76-79 choline O-acetyltransferase Rattus norvegicus 172-197 2928318-3 1989 Administered in combination with beta-NGF, GM1 produced a significant increase in choline acetyltransferase activity in the nucleus basalis magnocellularis and remaining cortex ipsilateral to the lesion. G(M1) Ganglioside 43-46 choline O-acetyltransferase Rattus norvegicus 82-107 3033257-5 1987 Rather, there were significant reductions of AChE and choline acetyltransferase activities in the ipsilateral hippocampus relative to the contralateral value (P less than .001); and the reductions were greater in GM1-treated rats than in untreated controls (P less than .001). G(M1) Ganglioside 213-216 choline O-acetyltransferase Rattus norvegicus 54-79 3445796-0 1987 Analysis of the time course of GM1 ganglioside effect on changes in choline acetyltransferase activity in partially denervated rat hippocampus. G(M1) Ganglioside 31-46 choline O-acetyltransferase Rattus norvegicus 68-93 7853166-3 1995 via a minipump, with various doses of NGF or GM1 for a period of 7 days prevented the lesion-induced decline in nucleus basalis magnocellularis choline acetyltransferase (ChAT) activity in a dose-dependent manner. G(M1) Ganglioside 45-48 choline O-acetyltransferase Rattus norvegicus 144-169 8622782-0 1995 GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain. G(M1) Ganglioside 0-3 choline O-acetyltransferase Rattus norvegicus 25-50 7789456-0 1995 Systemic administration of GM1 ganglioside increases choline acetyltransferase activity in the brain of aged rats. G(M1) Ganglioside 27-42 choline O-acetyltransferase Rattus norvegicus 53-78 3730833-2 1986 It was found that the enhancement of recovery of acetylcholinesterase, choline acetyltransferase and serotonin uptake by GM1 treatment (30 mg/kg i.m., daily), as studied on the 6th and 21st postlesion day, was dependent on the degree of fiber degeneration. G(M1) Ganglioside 121-124 choline O-acetyltransferase Rattus norvegicus 71-96 3524865-3 1986 ChAT-positive neurons also were stained for ganglioside GM1 by using an avidin-biotin complex technique. G(M1) Ganglioside 56-59 choline O-acetyltransferase Rattus norvegicus 0-4 6502758-1 1984 The effect of intramuscular administration of monosialoganglioside (GM1) on postlesion responses of choline acetyltransferase and acetylcholinesterase activity in partially deafferented rat hippocampus was studied at various survival times. G(M1) Ganglioside 68-71 choline O-acetyltransferase Rattus norvegicus 100-125 9668356-3 1998 Systemic administration of GM1 ganglioside, 30 mg/kg, i.p., for 30 days, enhances the cholinergic neurochemical presynaptic markers, choline acetyltransferase, choline uptake, and acetylcholine, in the brain and spinal cord of aged 22-24-month-old Sprague-Dawley rats. G(M1) Ganglioside 27-42 choline O-acetyltransferase Rattus norvegicus 133-158 7710670-8 1994 In young lesioned rats daily intraperitoneal administration of GM1 (30 mg/kg) for 21 days after surgery promoted both the recovery of choline acetyltransferase activity and passive avoidance performance. G(M1) Ganglioside 63-66 choline O-acetyltransferase Rattus norvegicus 134-159 7710670-10 1994 Only when GM1 administration was started 3 days before the lesion, were a complete recovery in choline acetyltransferase activity in the contralateral cortex and a partial recovery in the ipsilateral cortex obtained. G(M1) Ganglioside 10-13 choline O-acetyltransferase Rattus norvegicus 95-120 8239303-9 1993 GM1 treatment to aged rats was seen to potentiate the NGF-induced increase of ChAT activity in the striatum ipsilateral to the NGF infusion. G(M1) Ganglioside 0-3 choline O-acetyltransferase Rattus norvegicus 78-82 8239303-10 1993 Moreover, in the striatum contralateral to the NGF infusion, GM1 increased ChAT activity above the control values, whereas NGF treatment alone did not affect enzymatic activity. G(M1) Ganglioside 61-64 choline O-acetyltransferase Rattus norvegicus 75-79 1915720-3 1991 Newborn rats subjected to brain damage by NMDA and contemporaneously treated subcutaneously with GM1 showed significantly reduced (i) loss in hemispheric weight, (ii) loss in tissue choline acetyltransferase activity, and (iii) morphological damage in various brain areas. G(M1) Ganglioside 97-100 choline O-acetyltransferase Rattus norvegicus 182-207 8278055-7 1993 Monosialoganglioside GM1 or nerve growth factor treatment equally attenuated deficits in nucleus basalis magnocellularis cell size and cortical choline acetyltransferase immunoreactive fibre length. G(M1) Ganglioside 0-24 choline O-acetyltransferase Rattus norvegicus 144-169