PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25039425-6 2014 The increase in GM1 expression induced by leptin was inhibited after pre-treatment with inhibitors of phosphatidylinositol 3-kinase (LY294002), Akt (triciribine) and the mammalian target of rapamycin (i.e. rapamycin), but not by an inhibitor of extracellular signal-regulated kinase (PD98059). G(M1) Ganglioside 16-19 AKT serine/threonine kinase 1 Homo sapiens 144-147 25039425-10 2014 These results suggest that leptin significantly inhibits Abeta assembly by decreasing GM1 expression in DRMs of the neuronal surface through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway. G(M1) Ganglioside 86-89 AKT serine/threonine kinase 1 Homo sapiens 175-178 20237277-5 2010 Administration of GM1 restores ganglioside levels in HD cells and promotes activation of AKT and phosphorylation of mutant Htt, leading to decreased mutant Htt toxicity and increased survival of HD cells. G(M1) Ganglioside 18-21 AKT serine/threonine kinase 1 Homo sapiens 89-92