PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10399959-0 1999 Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. G(M1) Ganglioside 45-48 fibroblast growth factor 2 Homo sapiens 84-114 10399959-5 1999 We further show that GM1 and to a lesser extent GM2 modify bFGF binding to its receptor and inhibit the associated mitogenic signal-transduction pathway of protein-tyrosine phosphorylation of 40 to 120 kDa, PLCgamma1, MAP kinase and protein-kinase-C activation. G(M1) Ganglioside 21-24 fibroblast growth factor 2 Homo sapiens 59-63 10399959-7 1999 The observed differential modulation of bFGF-induced mitogenesis by GM1, GM2 and GM3 was at concentrations routinely occurring in the serum of cancer patients. G(M1) Ganglioside 68-71 fibroblast growth factor 2 Homo sapiens 40-44 27525911-5 2016 Cell counts and MTT assays demonstrated that in epidermal growth factor (EGF)- and basic fibroblast growth factor (bFGF)-containing medium, a high concentration of GM1, but not NGF, significantly elevated NSC proliferation. G(M1) Ganglioside 164-167 fibroblast growth factor 2 Homo sapiens 115-119 9950679-4 1999 Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b > GD1b > GM1 = GM2 = sulfatide > GM3 = galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective. G(M1) Ganglioside 149-152 fibroblast growth factor 2 Homo sapiens 34-39 9950679-10 1999 Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and asialo-GM1, prevent the binding of 125I-FGF-2 to a soluble, recombinant form of extracellular FGFR-1. G(M1) Ganglioside 24-27 fibroblast growth factor 2 Homo sapiens 94-99 9950679-11 1999 Conversely, the soluble receptor and free heparin inhibit the interaction of fluorochrome-labeled GM1 to immobilized FGF-2. G(M1) Ganglioside 98-101 fibroblast growth factor 2 Homo sapiens 117-122 19849946-7 2009 RESULTS: High concentrations of GM1 (100 ng/L and 200 ng/L) promoted significantly the proliferation of NSCs in the medium containing EGF and bFGF (p<0.05). G(M1) Ganglioside 32-35 fibroblast growth factor 2 Homo sapiens 142-146 18768683-4 2008 We show that activation of FGF receptor(s) by FGF2 leads to palmitoylation of the two major transmembrane NCAM isoforms, NCAM140 and NCAM180, translocation of NCAM to GM1 ganglioside-containing lipid rafts, and stimulation of neurite outgrowth of hippocampal neurons. G(M1) Ganglioside 167-182 fibroblast growth factor 2 Homo sapiens 46-50