PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18028334-0	2008	GM1-induced activation of phosphatidylinositol 3-kinase: involvement of Trk receptors.	G(M1) Ganglioside	0-3	neurotrophic receptor tyrosine kinase 1	Homo sapiens	72-75	
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	G(M1) Ganglioside	17-20	neurotrophic receptor tyrosine kinase 1	Homo sapiens	59-63	
20659560-5	2010	The data show that anti-GM1 antibodies found in patients" sera but not control sera inhibit NGF-induced Trk autophosphorylation.	G(M1) Ganglioside	24-27	neurotrophic receptor tyrosine kinase 1	Homo sapiens	104-107	
18028334-2	2008	In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 1	Homo sapiens	28-31	
18028334-7	2008	PI3-kinase activity was found increased in Trk and Gab1 immunoprecipitates, and co-immunoprecipitation studies demonstrated the association of Trk and Gab1 after GM1 treatment.	G(M1) Ganglioside	162-165	neurotrophic receptor tyrosine kinase 1	Homo sapiens	143-146	
18028334-10	2008	Our findings suggest that GM1 induces activation of PI3-kinase that is, in part, mediated through Trk and Gab1.	G(M1) Ganglioside	26-29	neurotrophic receptor tyrosine kinase 1	Homo sapiens	98-101	
17355906-2	2007	The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1.	G(M1) Ganglioside	48-63	neurotrophic receptor tyrosine kinase 1	Homo sapiens	8-12	
17355906-2	2007	The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1.	G(M1) Ganglioside	48-51	neurotrophic receptor tyrosine kinase 1	Homo sapiens	8-12	
17355906-3	2007	The IgGs purified from patients" sera inhibited the NGF-TrkA signaling in GM1 pre-incubated PC12 cells.	G(M1) Ganglioside	74-77	neurotrophic receptor tyrosine kinase 1	Homo sapiens	56-60	
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	38-41	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230	
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	95-98	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230	
17355906-7	2007	These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling.	G(M1) Ganglioside	95-98	neurotrophic receptor tyrosine kinase 1	Homo sapiens	226-230	
14630342-1	2003	PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB).	G(M1) Ganglioside	136-139	neurotrophic receptor tyrosine kinase 1	Homo sapiens	83-87	
16971381-7	2007	The GM1 ganglioside specific cholera toxin subunit B applied to TrkA-PC12 cells has no inhibitory effect on NGF-induced sialidase activity.	G(M1) Ganglioside	4-19	neurotrophic receptor tyrosine kinase 1	Homo sapiens	64-68	
14630342-8	2003	These data indicate that GM1/ligand interaction does not necessarily lead to neuritogenesis and suggest that a specialisation of CTB, not shared by anti-GM1 antibodies or rETxB, is required to activate TrkA.	G(M1) Ganglioside	25-28	neurotrophic receptor tyrosine kinase 1	Homo sapiens	202-206	
9668343-7	1998	GM3 inhibits both the epidermal growth factor receptor and basic fibroblast factor receptor; several gangliosides except GM3 inhibit the platelet-derived growth-factor receptor; GM1 enhances nerve growth-factor-stimulated activation of TrkA; insulin receptor is inhibited to varying degrees by several gangliosides, but 2-->3 sialosylparagloboside is most effective.	G(M1) Ganglioside	178-181	neurotrophic receptor tyrosine kinase 1	Homo sapiens	236-240	
12829403-2	2002	GM1 ganglioside has been shown to activate Trk, the tyrosine kinase receptor implicated in the neuroprotective properties of the neurotrophins.	G(M1) Ganglioside	0-15	neurotrophic receptor tyrosine kinase 1	Homo sapiens	43-46	
9668377-0	1998	Effect of GM1 on TrkA dimerization.	G(M1) Ganglioside	10-13	neurotrophic receptor tyrosine kinase 1	Homo sapiens	17-21