PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16971381-7 2007 The GM1 ganglioside specific cholera toxin subunit B applied to TrkA-PC12 cells has no inhibitory effect on NGF-induced sialidase activity. G(M1) Ganglioside 4-19 neurotrophic receptor tyrosine kinase 1 Homo sapiens 64-68 22496904-6 2012 The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR). G(M1) Ganglioside 17-20 neurotrophic receptor tyrosine kinase 1 Homo sapiens 59-63 18028334-0 2008 GM1-induced activation of phosphatidylinositol 3-kinase: involvement of Trk receptors. G(M1) Ganglioside 0-3 neurotrophic receptor tyrosine kinase 1 Homo sapiens 72-75 18028334-2 2008 In brain, GM1 activates the Trk receptors for neurotrophins and the Raf/MEK/ERK cascade in situ and in vivo. G(M1) Ganglioside 10-13 neurotrophic receptor tyrosine kinase 1 Homo sapiens 28-31 18028334-7 2008 PI3-kinase activity was found increased in Trk and Gab1 immunoprecipitates, and co-immunoprecipitation studies demonstrated the association of Trk and Gab1 after GM1 treatment. G(M1) Ganglioside 162-165 neurotrophic receptor tyrosine kinase 1 Homo sapiens 143-146 18028334-10 2008 Our findings suggest that GM1 induces activation of PI3-kinase that is, in part, mediated through Trk and Gab1. G(M1) Ganglioside 26-29 neurotrophic receptor tyrosine kinase 1 Homo sapiens 98-101 20659560-5 2010 The data show that anti-GM1 antibodies found in patients" sera but not control sera inhibit NGF-induced Trk autophosphorylation. G(M1) Ganglioside 24-27 neurotrophic receptor tyrosine kinase 1 Homo sapiens 104-107 17355906-2 2007 The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1. G(M1) Ganglioside 48-63 neurotrophic receptor tyrosine kinase 1 Homo sapiens 8-12 17355906-2 2007 The NGF-TrkA signaling is enhanced by exogenous GM1 ganglioside and this phenomenon is regarded as one of the functional aspects of GM1. G(M1) Ganglioside 48-51 neurotrophic receptor tyrosine kinase 1 Homo sapiens 8-12 17355906-3 2007 The IgGs purified from patients" sera inhibited the NGF-TrkA signaling in GM1 pre-incubated PC12 cells. G(M1) Ganglioside 74-77 neurotrophic receptor tyrosine kinase 1 Homo sapiens 56-60 17355906-7 2007 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside 38-41 neurotrophic receptor tyrosine kinase 1 Homo sapiens 226-230 17355906-7 2007 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside 95-98 neurotrophic receptor tyrosine kinase 1 Homo sapiens 226-230 17355906-7 2007 These results suggested that the anti-GM1 antibody could play roles in pathophysiology in anti-GM1 antibody positive GBS through interfering with the neurotrophic action of NGF and GM1 mediated signal modulation including NGF-TrkA signaling. G(M1) Ganglioside 95-98 neurotrophic receptor tyrosine kinase 1 Homo sapiens 226-230 14630342-1 2003 PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB). G(M1) Ganglioside 136-139 neurotrophic receptor tyrosine kinase 1 Homo sapiens 83-87 14630342-8 2003 These data indicate that GM1/ligand interaction does not necessarily lead to neuritogenesis and suggest that a specialisation of CTB, not shared by anti-GM1 antibodies or rETxB, is required to activate TrkA. G(M1) Ganglioside 25-28 neurotrophic receptor tyrosine kinase 1 Homo sapiens 202-206 12829403-2 2002 GM1 ganglioside has been shown to activate Trk, the tyrosine kinase receptor implicated in the neuroprotective properties of the neurotrophins. G(M1) Ganglioside 0-15 neurotrophic receptor tyrosine kinase 1 Homo sapiens 43-46 9668377-0 1998 Effect of GM1 on TrkA dimerization. G(M1) Ganglioside 10-13 neurotrophic receptor tyrosine kinase 1 Homo sapiens 17-21 9668343-7 1998 GM3 inhibits both the epidermal growth factor receptor and basic fibroblast factor receptor; several gangliosides except GM3 inhibit the platelet-derived growth-factor receptor; GM1 enhances nerve growth-factor-stimulated activation of TrkA; insulin receptor is inhibited to varying degrees by several gangliosides, but 2-->3 sialosylparagloboside is most effective. G(M1) Ganglioside 178-181 neurotrophic receptor tyrosine kinase 1 Homo sapiens 236-240