PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19118221-5	2009	We found that laminin-1-mediated clustering of GM1 causes the translocation and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites.	G(M1) Ganglioside	47-50	AKT serine/threonine kinase 1	Rattus norvegicus	196-199	
33733293-0	2021	Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3beta Pathway.	G(M1) Ganglioside	21-24	AKT serine/threonine kinase 1	Rattus norvegicus	118-121	
33733293-8	2021	To determine whether GM1 exerted its effect via the PI3K/AKT/GSK3beta pathway, PC12 cells were incubated with LY294002, a PI3K inhibitor.	G(M1) Ganglioside	21-24	AKT serine/threonine kinase 1	Rattus norvegicus	57-60	
33733293-10	2021	GM1 treatment increased the expression of p-AKT and p-GSK3beta.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	44-47	
33733293-11	2021	However, the anti-apoptotic effect of GM1 was eliminated after inhibiting the phosphorylation of AKT.	G(M1) Ganglioside	38-41	AKT serine/threonine kinase 1	Rattus norvegicus	97-100	
33733293-12	2021	We showed that GM1 lessens ketamine-induced apoptosis in the hippocampus and cortex of young rats by regulating the PI3K/AKT/GSK3beta pathway.	G(M1) Ganglioside	15-18	AKT serine/threonine kinase 1	Rattus norvegicus	121-124	
26459480-3	2015	GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	121-124	
26459480-3	2015	GM1 in concentrations of 100 nM and 10 muM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	155-158	
26459480-4	2015	In the presence of PI3K inhibitor LY294002 preventing protein kinase Akt activation, the protective effect of GM1 significantly decreased.	G(M1) Ganglioside	110-113	AKT serine/threonine kinase 1	Rattus norvegicus	69-72	
26459480-5	2015	These findings suggest that activation of protein kinase Akt by GM1 contributes to improvement of PC12 cell viability by this ganglioside.	G(M1) Ganglioside	64-67	AKT serine/threonine kinase 1	Rattus norvegicus	57-60	
29428576-0	2018	Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	12-15	AKT serine/threonine kinase 1	Rattus norvegicus	145-148	
29428576-8	2018	Subsequently, GM1 potentiated the activation of the PI3K/AKT-Nrf2 pathway.	G(M1) Ganglioside	14-17	AKT serine/threonine kinase 1	Rattus norvegicus	57-60	
29428576-10	2018	Overall, GM1 may afford a protective intervention in HACE by suppressing oxidative stress and inflammatory response via activating the PI3K/AKT-Nrf2 pathway, implying a promising agent for the treatment of HACE.	G(M1) Ganglioside	9-12	AKT serine/threonine kinase 1	Rattus norvegicus	140-143	
25216715-0	2014	GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity.	G(M1) Ganglioside	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	37-40	
25216715-5	2014	GM1 (100 nM and 10 microM) increased the basal activity of Akt, but did not change Akt activity in cells exposed to hydrogen peroxide.	G(M1) Ganglioside	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	59-62	
25216715-8	2014	Thus, the protective and metabolic effects of GM1 ganglioside on PC12 cells exposed to hydrogen peroxide appear to depend on the activation of Trk receptor tyrosine kinase and downstream activation of Akt and ERK1/2.	G(M1) Ganglioside	46-61	AKT serine/threonine kinase 1	Rattus norvegicus	201-204