PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26714044-7 2016 Cultures of coronary endothelial cells and monocytes stimulated with TNF-alpha secreted less pro-inflammatory cytokines in the presence of CS (P < 0.01). Chondroitin Sulfates 139-141 tumor necrosis factor Homo sapiens 69-78 30521103-0 2019 Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33. Chondroitin Sulfates 0-19 tumor necrosis factor Homo sapiens 42-45 30521103-5 2019 Preincubation with CS had no effect on MC degranulation stimulated by SP, but inhibited TNF (60%) and CXCL8 (45%) secretion from LAD2 cells stimulated by IL-33. Chondroitin Sulfates 19-21 tumor necrosis factor Homo sapiens 88-91 30521103-12 2019 The findings in this article show that CS inhibits secretion of TNF and CXCL8 from human cultured MC stimulated by IL-33. Chondroitin Sulfates 39-41 tumor necrosis factor Homo sapiens 64-67 29371215-16 2018 Tumor necrosis factor-alpha was identified as a direct binding partner of CS glycosaminoglycan chains, and rhASB reduced tumor necrosis factor-alpha-induced inflammatory gene activation in vitro in endothelial cells and macrophages. Chondroitin Sulfates 74-76 tumor necrosis factor Homo sapiens 0-27 26714044-8 2016 CS reduced the activation of the TNF-alpha signaling pathway in endothelial cells (pErk 36% of reduction, and NFkappaB 33% of reduction), and the migration of activated monocytes to inflamed endothelial cells in transwells (81 +- 6 vs. 13 +- 2, P < 0.001). Chondroitin Sulfates 0-2 tumor necrosis factor Homo sapiens 33-42 26714044-9 2016 CONCLUSIONS: CS interferes with the pro-inflammatory activation of monocytes and endothelial cells driven by TNF-alpha thus reducing the propagation of inflammation and preventing the formation of atherosclerotic plaques. Chondroitin Sulfates 13-15 tumor necrosis factor Homo sapiens 109-118 23276728-6 2013 CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27. Chondroitin Sulfates 0-2 tumor necrosis factor Homo sapiens 97-105 25534363-8 2015 RESULTS: NCCM (10 & 100%), CS (10 and 100 mug) and Noggin (10 and 100 ng) significantly decreased cell invasion of HUVECs with and without TNFalpha. Chondroitin Sulfates 31-33 tumor necrosis factor Homo sapiens 143-151 25534363-9 2015 NCCM 10% and Noggin 10 ng inhibited tubular formation with and without TNFalpha and CS 100 mug inhibited tubules in Basal conditions whereas CS 10 mug inhibited tubules with TNFalpha. Chondroitin Sulfates 141-143 tumor necrosis factor Homo sapiens 174-182 25261974-9 2014 In a dose-dependent manner, CS significantly inhibited IL-1beta (p = 0.003), and TNFalpha (p = 0.02) production from macrophages in response to MSU. Chondroitin Sulfates 28-30 tumor necrosis factor Homo sapiens 81-89 20110869-9 2009 The inhibition of MMP3 secretion due to GS plus CS was accompanied by a decrease in TNF-alpha production. Chondroitin Sulfates 48-50 tumor necrosis factor Homo sapiens 84-93 20965281-5 2011 Positively charged TGF-beta1 demonstrated minimal release after loading in CS microspheres, while negatively charged TNF-alpha exhibited substantial release over the first 15 h, suggesting that TGF-beta1 electrostatically complexed with CS. Chondroitin Sulfates 237-239 tumor necrosis factor Homo sapiens 117-126 19346317-3 2010 When ASB was silenced and IL-8 production stimulated by exposure to TNF-alpha, ASB activity declined by roughly 75%, cellular C4S content increased by over 7.5 microg/mg protein, cell-bound IL-8 increased by over 530 pg/mg protein, and secreted IL-8 declined by over 520 pg/mg protein in all cell lines (P < 0.001). Chondroitin Sulfates 126-129 tumor necrosis factor Homo sapiens 68-77 19516009-13 2009 Increased expression of chondroitin sulfate in retina and dermatan sulfate in choroid reflects the effects of injury and fibrosis using high doses of anti-TNF-alpha. Chondroitin Sulfates 24-43 tumor necrosis factor Homo sapiens 155-164 18295395-0 2008 Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells. Chondroitin Sulfates 0-19 tumor necrosis factor Homo sapiens 69-78 19296424-10 2009 RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation. Chondroitin Sulfates 96-115 tumor necrosis factor Homo sapiens 24-33 18295395-2 2008 Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Chondroitin Sulfates 58-77 tumor necrosis factor Homo sapiens 120-129 18295395-2 2008 Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Chondroitin Sulfates 79-81 tumor necrosis factor Homo sapiens 120-129 18295395-3 2008 Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Chondroitin Sulfates 24-26 tumor necrosis factor Homo sapiens 37-46 16771479-0 2006 Discovery of a TNF-alpha antagonist using chondroitin sulfate microarrays. Chondroitin Sulfates 42-61 tumor necrosis factor Homo sapiens 15-24 16771479-2 2006 Using the microarrays, we identify a novel interaction between CS and TNF-alpha, a proinflammatory cytokine involved in rheumatoid arthritis, Crohn"s disease, and psoriasis. Chondroitin Sulfates 63-65 tumor necrosis factor Homo sapiens 70-79 10222064-9 1999 Taken together, these data suggested that IL-4-mediated inhibition of TNFalpha-induced monocyte HA binding was dependent not only on protein synthesis, but also on N-linked glycosylation and chondroitin-sulfate modification of either CD44 or, alternatively, another monocyte protein(s) that may regulate the ability of CD44 to bind HA. Chondroitin Sulfates 191-210 tumor necrosis factor Homo sapiens 70-78 8150035-2 1994 When KM 102 cells were stimulated by TNF-alpha, they produced more M-CSF than that produced in unstimulated condition, in which PG-M-CSF had a shorter chondroitin sulfate chain. Chondroitin Sulfates 151-170 tumor necrosis factor Homo sapiens 37-46 34452074-3 2021 The present study offers two novel therapies based in advanced drug delivery systems for RA treatment: encapsulated chondroitin sulfate modified poly(amidoamine) dendrimer nanoparticles (NPs) covalently bonded to monoclonal anti-TNF alpha antibody in both Tyramine-Gellan Gum and Tyramine-Gellan Gum/Silk Fibroin hydrogels. Chondroitin Sulfates 116-135 tumor necrosis factor Homo sapiens 229-238 12244074-8 2002 Therefore, TNF-alpha induced a decrease in the percentage of CD44 sulfation due to chondroitin sulfate and an increase due to N- and O-linked sulfation. Chondroitin Sulfates 83-102 tumor necrosis factor Homo sapiens 11-20