PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22252626-1 2012 Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix and is considered to be crucial to several key cellular processes involved in development and disease. Chondroitin Sulfates 12-31 versican Homo sapiens 0-8 24390942-2 2013 Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Chondroitin Sulfates 14-33 versican Homo sapiens 0-8 23099107-2 2012 Versican, a large chondroitin sulfate proteoglycan and one of the major components of the extracellular matrix, plays an essential role in hair follicle formation. Chondroitin Sulfates 18-37 versican Homo sapiens 0-8 21596823-1 2011 PURPOSE: Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. Chondroitin Sulfates 56-75 versican Homo sapiens 9-17 21596823-1 2011 PURPOSE: Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. Chondroitin Sulfates 77-79 versican Homo sapiens 9-17 21078678-1 2011 Versican is a hyaluronan-binding, extracellular chondroitin sulfate proteoglycan produced by several tumor types, including malignant melanoma, which exists as four different splice variants. Chondroitin Sulfates 48-67 versican Homo sapiens 0-8 20164441-2 2010 The central hypothesis on follicular fluid formation suggests that production by granulosa cells of hyaluronan and the chondroitin sulfate proteoglycan versican generates an osmotic gradient. Chondroitin Sulfates 119-138 versican Homo sapiens 152-160 20489207-4 2010 Previous studies have shown that versican is a chondroitin sulfate proteoglycan of the ECM that is produced by synthetic SMCs and promotes SMC migration and proliferation. Chondroitin Sulfates 47-66 versican Homo sapiens 33-41 16257955-10 2006 These results suggest that versican/PG-M is involved in positively regulating the formation of the mesenchymal matrix and the onset of chondrocyte differentiation through the attached chondroitin sulfate chains. Chondroitin Sulfates 184-203 versican Homo sapiens 27-35 18485243-2 2008 Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican. Chondroitin Sulfates 151-171 versican Homo sapiens 204-212 16431924-1 2006 We have detected versican, a member of the large chondroitin sulfate proteoglycans, and its degraded C-terminal G3 fragments in human plasma and observed that the versican G3 domain promoted blood coagulation. Chondroitin Sulfates 49-68 versican Homo sapiens 17-25 16257955-2 2006 Versican/PG-M, a large chondroitin sulfate proteoglycan, is one of the major molecules expressed in the extracellular matrix during condensation. Chondroitin Sulfates 23-42 versican Homo sapiens 0-8 19269971-1 2009 Versican is a large chondroitin sulfate proteoglycan of the extracellular matrix that is involved in a variety of cellular processes. Chondroitin Sulfates 20-39 versican Homo sapiens 0-8 19688944-4 2009 Versican is a chondroitin sulfate proteoglycan that constitutes the main component of the ECM. Chondroitin Sulfates 14-33 versican Homo sapiens 0-8 16847433-1 2006 Versican is a large chondroitin sulfate proteoglycan produced by several tumor cell types, including malignant melanoma, which exists as four different splice variants. Chondroitin Sulfates 20-39 versican Homo sapiens 0-8 16845893-1 2006 Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease. Chondroitin Sulfates 12-31 versican Homo sapiens 0-8 13680853-8 2003 Although the size of chondroitin sulfate chains is identical in both versican preparations, a significant increase in the percentage of 6-sulfated disaccharides is observed in chondroitin sulfate chains of versican in aneurysmal aortas, which is accompanied by decrease in 4-sulfated and non-sulfated units. Chondroitin Sulfates 176-195 versican Homo sapiens 206-214 16043844-11 2005 CSPG2 encodes versican, a large chondroitin sulfate proteoglycan, which, in vitreous, binds to hyaluronan and link protein and forms large aggregates that are important for maintaining structural integrity. Chondroitin Sulfates 32-51 versican Homo sapiens 0-5 16043844-11 2005 CSPG2 encodes versican, a large chondroitin sulfate proteoglycan, which, in vitreous, binds to hyaluronan and link protein and forms large aggregates that are important for maintaining structural integrity. Chondroitin Sulfates 32-51 versican Homo sapiens 14-22 14695326-3 2004 A variant of the chondroitin sulfate proteoglycan versican, V3, which lacks chondroitin sulfate, has recently been shown to stimulate elastic fiber assembly and decrease proliferation when expressed by retroviral transduction in arterial smooth muscle cells. Chondroitin Sulfates 17-36 versican Homo sapiens 50-58 14695326-3 2004 A variant of the chondroitin sulfate proteoglycan versican, V3, which lacks chondroitin sulfate, has recently been shown to stimulate elastic fiber assembly and decrease proliferation when expressed by retroviral transduction in arterial smooth muscle cells. Chondroitin Sulfates 76-95 versican Homo sapiens 50-58 11805102-3 2002 In pull-down assays and immunoprecipitation, beta(1)-integrin bound to the C-terminal domain of PG-M/versican, an extracellular chondroitin sulfate proteoglycan. Chondroitin Sulfates 128-147 versican Homo sapiens 101-109 10359644-5 1999 Western blotting of the CS proteoglycan showed that this had reactivity with antibodies raised against human versican. Chondroitin Sulfates 24-26 versican Homo sapiens 109-117 10950950-0 2000 Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44. Chondroitin Sulfates 19-38 versican Homo sapiens 70-78 10950950-1 2000 Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44. Chondroitin Sulfates 26-45 versican Homo sapiens 60-68 10950950-2 2000 The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44. Chondroitin Sulfates 51-70 versican Homo sapiens 85-93 10950950-2 2000 The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44. Chondroitin Sulfates 72-74 versican Homo sapiens 85-93 10950950-7 2000 Consistent with these results, structural analysis showed that versican is modified with at least CS B and CS C. Thus, proteoglycans sufficiently modified with the appropriate glycosaminoglycans should be able to bind L-selectin, P-selectin, and/or CD44. Chondroitin Sulfates 98-100 versican Homo sapiens 63-71 10359644-6 1999 Electron microscopy (EM) of the CS proteoglycan also revealed a versican-like structure, with one globular domain at each end of a long extended segment substituted with CS side chains, as well as a structure interpreted as being the heavy chain of ITI attached to CS chains. Chondroitin Sulfates 32-34 versican Homo sapiens 64-72 9056268-1 1997 Platelet-derived growth factor (PDGF) stimulates not only the proliferation and migration of arterial smooth muscle cells (ASMCs), but also the transcription, translation, and posttranslational processing of versican, a large chondroitin sulfate proteoglycan present in the extracellular matrix of blood vessels. Chondroitin Sulfates 226-245 versican Homo sapiens 208-216 8270643-2 1993 We showed previously that a large chondroitin sulfate proteoglycan, PG-M (also known as versican), inhibits cell-substratum adhesion, while basement membrane heparan sulfate proteoglycan (recently named perlecan) does not (Yamagata et al. Chondroitin Sulfates 34-53 versican Homo sapiens 88-96 7783424-4 1995 Recently, the large chondroitin sulfate (CS) proteoglycan, versican, has been identified in the dermis in association with elastic fibers, and the smaller CS proteoglycan, decorin, has been shown to codistribute with collagen fibers. Chondroitin Sulfates 41-43 versican Homo sapiens 59-67 8373377-6 1993 Northern-blot analyses of total RNA revealed a pronounced decrease in the steady-state mRNA levels of versican, the large chondroitin sulphate, with levels corresponding to 10-30% of controls. Chondroitin Sulfates 122-142 versican Homo sapiens 102-110 7531202-2 1994 We previously showed that many tissues and cells express alternatively spliced multiforms of the large chondroitin sulphate proteoglycan termed PG-M (versican is one of the short transcripts). Chondroitin Sulfates 103-123 versican Homo sapiens 150-158 34221961-7 2021 VCAN encodes a large chondroitin sulfate proteoglycan that is the main component of the extracellular matrix, and PDGFRB encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. Chondroitin Sulfates 21-40 versican Homo sapiens 0-4 1478664-1 1992 Versican is a major chondroitin sulfate proteoglycan of vascularized connective tissues whose eponym reflects its functional versatility in macromolecular affinity and interactions. Chondroitin Sulfates 20-39 versican Homo sapiens 0-8 34666527-1 2021 Versican, a chondroitin sulfate proteoglycan, is an essential component of the extracellular matrix (ECM) in inflammatory lung disease. Chondroitin Sulfates 12-31 versican Homo sapiens 0-8 34626407-1 2022 Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). Chondroitin Sulfates 33-52 versican Homo sapiens 0-8 35385326-1 2022 Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. Chondroitin Sulfates 46-65 versican Homo sapiens 20-28 35385326-1 2022 Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. Chondroitin Sulfates 46-65 versican Homo sapiens 30-34 32854301-1 2020 The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican). Chondroitin Sulfates 87-106 versican Homo sapiens 4-8 33604385-2 2021 Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer. Chondroitin Sulfates 21-40 versican Homo sapiens 0-8 33604385-2 2021 Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer. Chondroitin Sulfates 21-40 versican Homo sapiens 10-14 33149218-5 2020 We found that versican, a large chondroitin sulfate PG, promotes collagen fibrillogenesis in a turbidity assay and upregulates cell-mediated collagen compaction and reorganization, whereas aggrecan, a structurally-similar large PG, has different and often opposing effects on collagen. Chondroitin Sulfates 32-51 versican Homo sapiens 14-22 33131383-1 2020 Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family. Chondroitin Sulfates 20-39 versican Homo sapiens 0-8 32854301-1 2020 The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican). Chondroitin Sulfates 87-106 versican Homo sapiens 9-17 32854301-1 2020 The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican). Chondroitin Sulfates 87-106 versican Homo sapiens 123-128 32854301-1 2020 The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican). Chondroitin Sulfates 87-106 versican Homo sapiens 129-137 27683612-3 2016 Versican is a chondroitin sulfate proteoglycan in the vascular extracellular matrix that accumulates following vascular injury and promotes smooth-muscle cell proliferation in systemic arteries. Chondroitin Sulfates 14-33 versican Homo sapiens 0-8 31532704-2 2020 Versican (VCAN), a chondroitin sulphate proteoglycan promotes progression in solid tumours but there is dearth of literature in MM. Chondroitin Sulfates 19-39 versican Homo sapiens 0-8 31532704-2 2020 Versican (VCAN), a chondroitin sulphate proteoglycan promotes progression in solid tumours but there is dearth of literature in MM. Chondroitin Sulfates 19-39 versican Homo sapiens 10-14 29310782-1 2018 Versican is a chondroitin sulfate proteoglycan found in the extracellular matrix that is important for changes in cell phenotype associated with development and disease. Chondroitin Sulfates 14-33 versican Homo sapiens 0-8 28684419-2 2017 Versican is a large chondroitin sulfate-containing, hyaluronic acid-binding proteoglycan present in the extracellular matrix and in ocular vitreous body. Chondroitin Sulfates 20-39 versican Homo sapiens 0-8