PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25662098-8 2015 Binding experiments and chondroitinase treatment confirmed low affinity binding to chondroitin sulphate chains on cells lacking both M-CSFR and RPTPbeta/zeta. Chondroitin Sulfates 83-103 protein tyrosine phosphatase receptor type Z1 Homo sapiens 144-152 26896299-2 2016 Much of its activity is attributed to its interactions with the chondroitin sulfate (CS) proteoglycan, receptor type protein tyrosine phosphatase zeta (PTPRZ). Chondroitin Sulfates 64-83 protein tyrosine phosphatase receptor type Z1 Homo sapiens 152-157 26896299-6 2016 Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ. Chondroitin Sulfates 129-150 protein tyrosine phosphatase receptor type Z1 Homo sapiens 185-190 26896299-6 2016 Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ. Chondroitin Sulfates 20-22 protein tyrosine phosphatase receptor type Z1 Homo sapiens 185-190 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 80-99 protein tyrosine phosphatase receptor type Z1 Homo sapiens 0-7 25644401-1 2015 BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). Chondroitin Sulfates 81-101 protein tyrosine phosphatase receptor type Z1 Homo sapiens 61-69 25644401-1 2015 BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). Chondroitin Sulfates 103-105 protein tyrosine phosphatase receptor type Z1 Homo sapiens 61-69 23744080-8 2013 IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties. Chondroitin Sulfates 79-81 protein tyrosine phosphatase receptor type Z1 Homo sapiens 145-153 23744080-8 2013 IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties. Chondroitin Sulfates 79-81 protein tyrosine phosphatase receptor type Z1 Homo sapiens 210-218 23744080-8 2013 IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties. Chondroitin Sulfates 219-221 protein tyrosine phosphatase receptor type Z1 Homo sapiens 145-153 23744080-8 2013 IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties. Chondroitin Sulfates 219-221 protein tyrosine phosphatase receptor type Z1 Homo sapiens 210-218 16955703-5 2006 One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Chondroitin Sulfates 41-60 protein tyrosine phosphatase receptor type Z1 Homo sapiens 86-96 16955703-5 2006 One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Chondroitin Sulfates 41-60 protein tyrosine phosphatase receptor type Z1 Homo sapiens 207-217 16955703-5 2006 One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Chondroitin Sulfates 41-60 protein tyrosine phosphatase receptor type Z1 Homo sapiens 233-241 14697661-9 2003 Examining the effects of phosphacan on axon growth from rat E17 cortical neurons, we found that phosphacan stimulates outgrowth in a largely CS dependent manner, while it blocks the outgrowth-promoting effects of laminin through an interaction that is not affected by removal of the CS chains. Chondroitin Sulfates 283-285 protein tyrosine phosphatase receptor type Z1 Homo sapiens 96-106 14697661-6 2003 In contrast to the core glycoprotein, the phosphacan chondroitin sulfate (CS) glycosaminoglycan epitope DSD-1 was up-regulated after 7 dpl. Chondroitin Sulfates 53-72 protein tyrosine phosphatase receptor type Z1 Homo sapiens 42-52 14697661-6 2003 In contrast to the core glycoprotein, the phosphacan chondroitin sulfate (CS) glycosaminoglycan epitope DSD-1 was up-regulated after 7 dpl. Chondroitin Sulfates 74-76 protein tyrosine phosphatase receptor type Z1 Homo sapiens 42-52 14697661-9 2003 Examining the effects of phosphacan on axon growth from rat E17 cortical neurons, we found that phosphacan stimulates outgrowth in a largely CS dependent manner, while it blocks the outgrowth-promoting effects of laminin through an interaction that is not affected by removal of the CS chains. Chondroitin Sulfates 141-143 protein tyrosine phosphatase receptor type Z1 Homo sapiens 96-106 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 80-99 protein tyrosine phosphatase receptor type Z1 Homo sapiens 8-16 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 101-103 protein tyrosine phosphatase receptor type Z1 Homo sapiens 0-7 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 101-103 protein tyrosine phosphatase receptor type Z1 Homo sapiens 8-16 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 201-203 protein tyrosine phosphatase receptor type Z1 Homo sapiens 0-7 12684467-1 2003 PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding. Chondroitin Sulfates 201-203 protein tyrosine phosphatase receptor type Z1 Homo sapiens 8-16 12684467-3 2003 An aberrant morphology of Purkinje cell dendrites such as multiple and disoriented primary dendrites was induced in slice cultures by (1) addition of a polyclonal antibody against the extracellular domain of PTPzeta, (2) inhibition of protein tyrosine phosphatase activity, (3) enzymatic removal of the CS chains, (4) addition of exogenous CS chains, and (5) addition of exogenous PTN, all of which disturb PTN-PTPzeta signaling. Chondroitin Sulfates 303-305 protein tyrosine phosphatase receptor type Z1 Homo sapiens 208-215 12684467-3 2003 An aberrant morphology of Purkinje cell dendrites such as multiple and disoriented primary dendrites was induced in slice cultures by (1) addition of a polyclonal antibody against the extracellular domain of PTPzeta, (2) inhibition of protein tyrosine phosphatase activity, (3) enzymatic removal of the CS chains, (4) addition of exogenous CS chains, and (5) addition of exogenous PTN, all of which disturb PTN-PTPzeta signaling. Chondroitin Sulfates 340-342 protein tyrosine phosphatase receptor type Z1 Homo sapiens 208-215 10212223-12 1999 These results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor. Chondroitin Sulfates 130-149 protein tyrosine phosphatase receptor type Z1 Homo sapiens 98-105 12204104-6 2002 MK binds to the chondroitin sulfate portion of PTPzeta with high affinity. Chondroitin Sulfates 16-35 protein tyrosine phosphatase receptor type Z1 Homo sapiens 47-54 9660874-1 1998 Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan. Chondroitin Sulfates 220-239 protein tyrosine phosphatase receptor type Z1 Homo sapiens 124-131 8051107-5 1994 Digestion with chondroitinase ABC eliminated this smear and gave rise to a 310/300-kDa doublet band that was not detected without digestion, indicating that almost all of the RPTP beta molecules in the brain contain chondroitin sulfate chains. Chondroitin Sulfates 216-235 protein tyrosine phosphatase receptor type Z1 Homo sapiens 175-184 9507007-6 1998 The chondroitin sulfate chains on neurocan and phosphacan account for at least 80% of their binding to amphoterin and HB-GAM. Chondroitin Sulfates 4-23 protein tyrosine phosphatase receptor type Z1 Homo sapiens 47-57 8663515-4 1996 The contribution of chondroitin sulfate chains to the binding of neurocan and phosphacan to TAG-1/axonin-1 is therefore the opposite of that previously observed for their binding to two other Ig-superfamily neural cell adhesion molecules, Ng-CAM/L1 and N-CAM. Chondroitin Sulfates 20-39 protein tyrosine phosphatase receptor type Z1 Homo sapiens 78-88 8625816-1 1996 6B4 proteoglycan/phosphacan is one of the major phosphate-buffered saline-soluble chondroitin sulfate proteoglycans of the brain. Chondroitin Sulfates 82-101 protein tyrosine phosphatase receptor type Z1 Homo sapiens 17-27 8051107-7 1994 These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo. Chondroitin Sulfates 69-88 protein tyrosine phosphatase receptor type Z1 Homo sapiens 26-35 8051107-7 1994 These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo. Chondroitin Sulfates 133-153 protein tyrosine phosphatase receptor type Z1 Homo sapiens 26-35 8051107-7 1994 These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo. Chondroitin Sulfates 133-153 protein tyrosine phosphatase receptor type Z1 Homo sapiens 218-227 7514167-2 1994 Immunoprecipitation experiments of cells transfected with RPTP beta expression vector and metabolically labeled with [35S]sulfate and [35S]methionine indicate that the transmembrane form of RPTP beta is indeed a chondroitin sulfate proteoglycan. Chondroitin Sulfates 212-231 protein tyrosine phosphatase receptor type Z1 Homo sapiens 190-199 35053232-2 2022 Its wide expression in human tissues compared to the other component of group 5 of receptor phosphatases, PTPRZ expressed as a chondroitin sulfate proteoglycan in the central nervous system, has raised interest in its role as a possible regulatory switch of cell signaling processes. Chondroitin Sulfates 127-146 protein tyrosine phosphatase receptor type Z1 Homo sapiens 106-111