PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24726177-2 2014 Patients who inherit two mutated GALNS gene alleles have a decreased ability to degrade the glycosaminoglycans (GAGs) keratan sulfate and chondroitin 6-sulfate, thereby causing GAG accumulation within lysosomes and consequently pleiotropic disease. Chondroitin Sulfates 138-159 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 33-38 23451938-5 2013 Using a model system, we show herein that treatment of keloid tissues with chondroitinase ABC, an enzyme that specifically digests CS, improves clinical features of keloids. Chondroitin Sulfates 131-133 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 75-89 20600662-7 2010 CHase ABC-treatments suggested that CS is involved in the formation of phosphorylated focal adhesion kinase-positive focal contacts. Chondroitin Sulfates 36-38 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 0-5 23401410-1 2013 Mucopolysaccharidosis IVA (MPS IVA; OMIM #253000) is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), a lysosomal enzyme involved in the catabolism of keratan and chondroitin sulfate. Chondroitin Sulfates 193-212 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 124-129 20674212-6 2010 In particular, DeltaUA-->GalNAc-4S Na(2) and DeltaUA-->GalNAc-6S Na(2) were selected for quantitation of CS and DS because of their significant response and short migration time (less than 7min).The method was validated for linearity, accuracy, precision and it showed to be able in detecting selectively, DS and CS at impurity level (LOD 0.01%, w/w). Chondroitin Sulfates 111-113 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 61-70 22940367-6 2012 The active site of GALNS is a large, positively charged trench suitable for binding polyanionic substrates such as keratan sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 135-156 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 19-24 22521955-2 2012 The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 151-172 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 48-89 21715327-10 2011 These results suggest that this chondroitinase is useful for detailed structural and compositional analysis of chondroitin sulfate, preparation of specific chondroitin oligosaccharides, and study of baculovirus infection mechanism. Chondroitin Sulfates 111-130 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 32-46 18989752-1 2009 Morquio A is an autosomal recessive disease caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to the lysosomal accumulation of keratan-sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 184-205 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 115-120 20716181-1 2010 Mucopolysaccharidosis (MPS) IVA is an autosomal recessive disorder caused by deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate sulfatase (GALNS), which leads to the accumulation of keratan sulfate and chondroitin 6-sulfate, mainly in bone. Chondroitin Sulfates 217-238 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 154-159 14661246-7 2004 The chondroitin sulfate hydrogels degraded specifically in the presence of the enzyme chondroitinase. Chondroitin Sulfates 4-23 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 86-100 18285341-1 2008 The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS. Chondroitin Sulfates 143-145 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 108-113 18285341-5 2008 Following silencing of ASB or GALNS, total sGAG, C4S, and CS increased significantly. Chondroitin Sulfates 58-60 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 30-35 18285341-10 2008 mRNA expression of core proteins of the CS-containing proteoglycans, syndecan-1 and decorin, was significantly up-regulated following overexpression of ASB and GALNS. Chondroitin Sulfates 40-42 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 160-165 18285341-12 2008 These findings demonstrate that modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs. Chondroitin Sulfates 126-129 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 95-100 14585696-0 2004 Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase. Chondroitin Sulfates 26-47 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 77-91 17572406-8 2007 The ability of chondroitinase to degrade hyaluronan is likely to result in greater matrix disruption than the degradation of chondroitin sulphate alone. Chondroitin Sulfates 125-145 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 15-29 16287098-2 2005 GALNS is required to degrade glycosaminoglycans, keratan sulfate (KS), and chondroitin-6-sulfate. Chondroitin Sulfates 75-96 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 0-5 9395105-3 1997 Unsaturated disaccharide isomers of chondroitin sulfate, obtained following chondroitinase ACII digestion, were analyzed by high-performance liquid chromatography. Chondroitin Sulfates 36-55 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 76-90 12442278-2 2002 The deficiency of N-acetylgalactosamine-6-sulfate sulfatase leads to lysosomal accumulation of undegraded glycosaminoglycans, keratan sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 146-167 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 18-59 11290371-1 2001 In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis. Chondroitin Sulfates 139-159 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 61-75 11290371-1 2001 In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis. Chondroitin Sulfates 139-159 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 83-97 12489154-4 2002 GALNS cleaves the sulfate group from N-acetylgalactosamine 6-sulfate and galactose 6-sulfate, which are specifically found in keratan sulfate and chondroitin 6-sulfate. Chondroitin Sulfates 146-167 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 0-5 12489154-10 2002 We conclude that enamel defects associated with the loss of GALNS activity in persons with MPS IVA are likely to result from the pathological accumulation of keratan sulfate and chondroitin 6-sulfate in the lysosomes of secretory stage ameloblasts. Chondroitin Sulfates 178-199 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 60-65 34200496-1 2021 Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal disease caused by mutations in the gene encoding the enzymeN-acetylgalactosamine-6-sulfate sulfatase (GALNS), and is characterized by systemic skeletal dysplasia due to excessive storage of keratan sulfate (KS) and chondroitin-6-sulfate in chondrocytes. Chondroitin Sulfates 271-292 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 158-163 9194600-1 1997 Capillary zone electrophoresis (CZE) was used to separate the disaccharides produced by chondroitinase digestion of chondroitin sulfates. Chondroitin Sulfates 116-136 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 88-102 8051107-5 1994 Digestion with chondroitinase ABC eliminated this smear and gave rise to a 310/300-kDa doublet band that was not detected without digestion, indicating that almost all of the RPTP beta molecules in the brain contain chondroitin sulfate chains. Chondroitin Sulfates 216-235 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 15-29 8001980-1 1994 Deficiency of the lysosomal enzyme, N-acetylgalactosamine 6-sulfatase (GALNS;EC 3.1.6.4), results in the storage of the glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate, which leads to the lysosomal storage disorder Morquio A syndrome. Chondroitin Sulfates 160-181 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 36-69 8001980-1 1994 Deficiency of the lysosomal enzyme, N-acetylgalactosamine 6-sulfatase (GALNS;EC 3.1.6.4), results in the storage of the glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate, which leads to the lysosomal storage disorder Morquio A syndrome. Chondroitin Sulfates 160-181 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 71-76 1794040-1 1991 In this report we describe a system capable of resolving all of the known unsaturated disaccharides derived from the chondroitin sulphates, dermatan sulphate and hyaluronic acid by chondroitinase digestion. Chondroitin Sulfates 117-138 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 181-195 3104383-7 1987 It allows the simultaneous separation and analysis of HA and chondroitin sulfate isomers (after digestion of the latter with chondroitinase) at a higher speed, and with more sensitivity and efficiency. Chondroitin Sulfates 61-80 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 125-139 3401619-6 1988 Paper chromatography of the unsaturated disaccharides obtained by chondroitinase digestion showed that chondroitin sulfate chains were primarily 6-sulfated in the 2 studied extracts. Chondroitin Sulfates 103-122 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 66-80 6195665-3 1983 Separation of the various labeled glycosaminoglycans by chondroitinase digestion and chromatography revealed a transient rise from controls (P less than or equal to 0.05) in the proportion of labeled chondroitin 4-sulfate at 5 days, followed by an increase from controls (P less than or equal to 0.05) in proportionate labeling of dermatan sulfate at 15 and 45 days postbleomycin. Chondroitin Sulfates 200-221 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 56-70 3098423-0 1986 Release of inorganic sulfate ion under mild alkaline conditions from sulfated, unsaturated disaccharides obtained from chondroitin sulfates by chondroitinase digestion. Chondroitin Sulfates 119-139 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 143-157 2578417-2 1985 Characterization of the specificity of these antibodies indicated that they recognize determinants present in the keratan sulfate glycosaminoglycan chain and on chondroitin sulfate oligosaccharide stubs attached to the proteoglycan core protein after chondroitinase digestion of the proteoglycan (i.e., delta-unsaturated 4- and 6-sulfated and unsulfated chondroitin sulfate on the proteoglycan core). Chondroitin Sulfates 161-180 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 251-265 7118896-9 1982 The chondroitinase AC digest of the proteoglycan is sensitive to hydrolysis by chondro-4-sulfatase but not by chondro-6-sulfatase, indicating the presence of chondroitin 4-sulfate but not chondroitin 6-sulfate in the proteoglycan molecule. Chondroitin Sulfates 158-179 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 4-18 7118896-9 1982 The chondroitinase AC digest of the proteoglycan is sensitive to hydrolysis by chondro-4-sulfatase but not by chondro-6-sulfatase, indicating the presence of chondroitin 4-sulfate but not chondroitin 6-sulfate in the proteoglycan molecule. Chondroitin Sulfates 188-209 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 4-18 6809361-3 1982 Our results could be explained by the hypothesis that accumulation of keratan sulfate and chondroitin 6-sulfate in Morquio syndrome is due to a deficiency of galactose 6-sulfate sulfatase and N-acetylgalactosamine 6-sulfate sulfatase activity, which are necessary for the degradation of these two mucopolysaccharides. Chondroitin Sulfates 90-111 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 158-187 6809361-3 1982 Our results could be explained by the hypothesis that accumulation of keratan sulfate and chondroitin 6-sulfate in Morquio syndrome is due to a deficiency of galactose 6-sulfate sulfatase and N-acetylgalactosamine 6-sulfate sulfatase activity, which are necessary for the degradation of these two mucopolysaccharides. Chondroitin Sulfates 90-111 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 192-233 447623-0 1979 High performance liquid chromatography of unsaturated disaccharides produced from chondroitin sulfates by chondroitinase. Chondroitin Sulfates 82-102 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 106-120 6773185-1 1980 A 6-sulfated tetrasaccharide obtained by digesting chondroitin-6-sulfate with testicular hyaluronidase was used as a substrate for the determination of N-acetylgalactosamine-6-sulfate sulfatase activity. Chondroitin Sulfates 51-72 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 152-193 447623-1 1979 High performance liquid chromatography was performed by the ion pair method on unsaturated disaccharides produced from chondroitin sulfates by the action of chondroitinase. Chondroitin Sulfates 119-139 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 157-171 102653-2 1978 The substituted unsaturated disaccharides which result from digestion of chondroitin sulfates with chondroitinase are quickly separated on polar absorbents such as silica gel. Chondroitin Sulfates 73-93 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 99-113 820716-2 1976 Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase. Chondroitin Sulfates 165-186 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 6-47 150963-3 1978 Treatment of the phosphorylated proteoglycans with chondroitinase and chondrosulfatases effectively removed the chondroitin sulfate without dephosphorylating the remaining molecule. Chondroitin Sulfates 112-131 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 51-65 615734-2 1977 Paper chromatographic separation of the constitutional disaccharide units by digestion of chondroitin sulfates (CS) with chondroitinase-ABC and chondroitinase-AC was carried out after fractionation of CS by ion-exchange resin column chromatography. Chondroitin Sulfates 90-110 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 121-135 615734-2 1977 Paper chromatographic separation of the constitutional disaccharide units by digestion of chondroitin sulfates (CS) with chondroitinase-ABC and chondroitinase-AC was carried out after fractionation of CS by ion-exchange resin column chromatography. Chondroitin Sulfates 112-114 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 121-135 820716-2 1976 Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase. Chondroitin Sulfates 165-186 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 49-60 820716-2 1976 Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase. Chondroitin Sulfates 188-193 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 6-47 820716-2 1976 Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase. Chondroitin Sulfates 188-193 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 49-60 30959056-1 2019 Mucopolysaccharidosis IVA (MPS IVA or Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to lysosomal storage of keratan sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 220-241 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 160-165 5038324-4 1972 The growth of tumour cells which were injected subcutaneously after in vitro incubation with chondroitinase-ABC or -AC solution was decreased when compared with that of sham-treated cells.The injection of 1 ml of chondroitin sulphate A and chondroitin sulphate C solution prior to tumour inoculation into the same site promoted the tumour growth, while growth-stimulating effect of chondroitin sulphate B was ambiguous. Chondroitin Sulfates 213-235 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 93-107 33957983-1 2021 BACKGROUND: Mucopolysaccharidosis IVA (Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which results in the accumulation of the glycosaminoglycans (GAGs), keratan sulfate, and chondroitin-6-sulfate in the lysosomes of all tissues causing systemic dysfunction. Chondroitin Sulfates 265-286 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 168-173 33390680-1 2020 Morquio syndrome is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which is required for the catabolism of glycosaminoglycans (namely, chondroitin-6-sulfate and keratan sulfate). Chondroitin Sulfates 174-195 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 91-96 31994025-1 2020 Mucopolysaccharidosis IVA (Morquio A disease) is a genetic disorder caused by deficiency of N-acetylgalactosamine-6-sulfate-sulfatase (GALNS), leading to accumulation of keratan sulfate and chondroitin-6-sulfate in lysosomes. Chondroitin Sulfates 190-211 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 135-140 31398353-11 2019 The wide range of conditions where the benefits of chondroitinase treatment have been demonstrated reflects the complex roles that chondroitin sulphate proteoglycans (its substrate) play in health and disease and warrants the enzyme"s further development as a therapy. Chondroitin Sulfates 131-151 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 51-65 5647269-0 1968 Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion. Chondroitin Sulfates 58-78 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 82-96 33380731-6 2020 We found that intense removal of chondroitin sulfate (CS) and dermatan sulfate chains by chondroitinase ABC reduced the speed and decreased the strength of adhesion of HeLa cells. Chondroitin Sulfates 33-52 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 89-103 33380731-6 2020 We found that intense removal of chondroitin sulfate (CS) and dermatan sulfate chains by chondroitinase ABC reduced the speed and decreased the strength of adhesion of HeLa cells. Chondroitin Sulfates 54-56 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 89-103 32094233-2 2020 Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown. Chondroitin Sulfates 0-19 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 123-128 32094233-2 2020 Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown. Chondroitin Sulfates 143-162 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 107-121 32094233-2 2020 Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown. Chondroitin Sulfates 143-162 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 123-128 30305043-1 2018 BACKGROUND: Mucopolysaccharidosis-IVA (Morquio A disease) is a lysosomal disorder in which the abnormal accumulation of keratan sulfate and chondroitin-6-sulfate is consequent to mutations in the galactosamine-6-sulfatase (GALNS) gene. Chondroitin Sulfates 140-161 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 196-221 30305043-1 2018 BACKGROUND: Mucopolysaccharidosis-IVA (Morquio A disease) is a lysosomal disorder in which the abnormal accumulation of keratan sulfate and chondroitin-6-sulfate is consequent to mutations in the galactosamine-6-sulfatase (GALNS) gene. Chondroitin Sulfates 140-161 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 223-228 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 252-273 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 72-106 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 176-197 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 72-106 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 176-197 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 108-113 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 199-202 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 72-106 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 199-202 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 108-113 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 252-273 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 108-113 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 302-321 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 72-106 29245974-1 2017 The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate. Chondroitin Sulfates 302-321 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 108-113 28904929-2 2017 The loss of GALNS activity leads to the impaired breakdown of glycosaminoglycans (GAGs) keratan sulfate and chondroitin-6-sulfate. Chondroitin Sulfates 108-129 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 12-17 26172013-1 2015 Mucopolysaccharidosis type IV-A (Morquio A disease) is an autosomal recessive lysosomal storage disease caused by mutations in the gene encoding the N-acetylgalactosamine-6-sulfate sulfatase, that results in impaired catabolism of two glycosaminoglycans, chondroitin-6-sulfate and keratan sulfate. Chondroitin Sulfates 255-276 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 149-190 25496828-2 2015 A reduction in or absence of effective GALNS leads to faulty catabolism of keratan sulfate and chondroitin-6-sulfate within the lysosome; their accumulation causes cell, tissue, and organ dysfunction. Chondroitin Sulfates 95-116 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 39-44 25287660-3 2014 Tertiary GALNS structure was modeled and used for molecular docking against galactose-6-sulfate, N-acetylgalactosamine-6-sulfate, keratan sulfate, chondroitin-6-sulfate, and the artificial substrate 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate. Chondroitin Sulfates 147-168 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 9-14