PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1730778-10 1992 The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield. Chondroitin Sulfates 181-200 syndecan 1 Homo sapiens 295-303 14701864-5 2004 Specific glycosaminoglycan lyase digestions, followed by product analyses using fluorescence-assisted carbohydrate electrophoresis and immunoprecipitation experiments, showed that the p53 form is associated with syndecan-1 through both chondroitin sulfate and heparan sulfate. Chondroitin Sulfates 236-255 syndecan 1 Homo sapiens 212-222 12947106-8 2003 These results demonstrate that the LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1 and reinforce previous data suggesting specific properties for the precursor molecule. Chondroitin Sulfates 131-150 syndecan 1 Homo sapiens 161-171 7544118-9 1995 TGF-beta 1, alone or in combination with bFGF, also stimulated the CS content of syndecan-1, but none of the other syndecans was significantly affected by any of the factors or combinations tested. Chondroitin Sulfates 67-69 syndecan 1 Homo sapiens 81-91 8270643-10 1993 Syndecan-1, a membrane heparan sulfate/chondroitin sulfate proteoglycan, was associated with fibronectin at the cell surface, partly at focal contacts and in association with stress fibers. Chondroitin Sulfates 39-58 syndecan 1 Homo sapiens 0-10 19574454-0 2009 Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface. Chondroitin Sulfates 36-56 syndecan 1 Homo sapiens 90-98 19574454-1 2009 Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. Chondroitin Sulfates 99-118 syndecan 1 Homo sapiens 0-8 19574454-1 2009 Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. Chondroitin Sulfates 99-118 syndecan 1 Homo sapiens 10-13 19574454-1 2009 Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. Chondroitin Sulfates 120-122 syndecan 1 Homo sapiens 0-8 19574454-1 2009 Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. Chondroitin Sulfates 120-122 syndecan 1 Homo sapiens 10-13 19574454-8 2009 We propose that Dlp, which lacks CS modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand. Chondroitin Sulfates 143-145 syndecan 1 Homo sapiens 155-158 19298595-2 2009 As heparan sulphate and chondroitin sulphate are the bioactive components of syndecan-1, we analysed the signature of genes encoding 100 proteins involved in synthesis of these chains, i.e. from precursor uptake to post-translational modifications, using Affymetrix microarrays. Chondroitin Sulfates 24-44 syndecan 1 Homo sapiens 77-87 19298595-3 2009 The expression of enzymes required for heparan sulphate and chondroitin sulphate biosynthesis was shown to increase in parallel with syndecan-1 expression, throughout the differentiation of memory B cells into plasmablasts and normal bone marrow plasma cells. Chondroitin Sulfates 60-80 syndecan 1 Homo sapiens 133-143 18285341-10 2008 mRNA expression of core proteins of the CS-containing proteoglycans, syndecan-1 and decorin, was significantly up-regulated following overexpression of ASB and GALNS. Chondroitin Sulfates 40-42 syndecan 1 Homo sapiens 69-79 18285341-11 2008 Soluble syndecan-1 protein increased following increases in ASB and GALNS and reduced following silencing, inversely to changes in CS. Chondroitin Sulfates 131-133 syndecan 1 Homo sapiens 8-18 3144000-3 1988 One such molecule is a cell surface proteoglycan, named syndecan, that contains both heparan sulfate and chondroitin sulfate chains. Chondroitin Sulfates 105-124 syndecan 1 Homo sapiens 56-64 1969657-4 1990 Syndecan consists of chondroitin sulfate and heparan sulphate chains linked to a 31 kilodalton (kDa) integral membrane protein. Chondroitin Sulfates 21-40 syndecan 1 Homo sapiens 0-8 32388727-1 2020 Syndecan-1, is a transmembrane heparan/chondroitin sulfate proteoglycan necessary for cell-cell and cell-matrix interactions. Chondroitin Sulfates 39-58 syndecan 1 Homo sapiens 0-10 32623935-2 2020 An important feature of syndecan-1 related to its role in pathologies is that it can be shed from the surface of cells as an intact ectodomain composed of the extracellular core protein and attached heparan sulfate and chondroitin sulfate chains. Chondroitin Sulfates 219-238 syndecan 1 Homo sapiens 24-34 28849661-0 2017 Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide. Chondroitin Sulfates 13-34 syndecan 1 Homo sapiens 43-53 30919596-2 2019 Women are more susceptible to malaria during pregnancy due to malaria-induced inflammation and the sequestration of infected red blood cells in the placenta, which bind to the chondroitin sulfate portion of syndecan-1 on the syncytiotrophoblast and in the intervillous space. Chondroitin Sulfates 176-195 syndecan 1 Homo sapiens 207-217 30919596-9 2019 Inflammation also upregulates MMP-9 and the removal of heparan sulfate gives MMP-9 access to cleave syndecan-1, thereby releasing dimeric syndecan-1 ectodomains with at least four chondroitin sulfate chains attached. Chondroitin Sulfates 180-199 syndecan 1 Homo sapiens 138-148 23504321-0 2013 Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity. Chondroitin Sulfates 124-143 syndecan 1 Homo sapiens 33-43 27556547-0 2016 Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. Chondroitin Sulfates 118-139 syndecan 1 Homo sapiens 143-153 27556547-8 2016 Syncytial fusion of the BeWo cells, triggered by forskolin treatment, caused an increased expression of placental CS-modified syndecan-1. Chondroitin Sulfates 114-116 syndecan 1 Homo sapiens 126-136 27556547-9 2016 In line with this, we show that rVAR2 binding to placental CS impairs syndecan-1-related Src signaling in forskolin treated BeWo cells, but not in untreated cells. Chondroitin Sulfates 59-61 syndecan 1 Homo sapiens 70-80 25662098-9 2015 Amongst the proteoglycans with chondroitin sulphate chains, syndecan-1 was able to modulate the IL-34-induced M-CSFR signalling pathways. Chondroitin Sulfates 31-51 syndecan 1 Homo sapiens 60-70