PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28846826-5 2017 Recent studies have implicated anti-PF4 antibodies that are able to bridge two PF4 tetramers even in the absence of heparin, probably facilitated by non-heparin platelet-associated polyanions (chondroitin sulfate and polyphosphates); nascent PF4-aHIT-IgG complexes recruit additional heparin-dependent HIT antibodies, leading to the formation of large multimolecular immune complexes and marked platelet activation. Chondroitin Sulfates 193-212 platelet factor 4 Homo sapiens 36-39 25342714-5 2015 The findings suggest that although all HIT antibodies recognize PF4 in a complex with heparin, only a subset of these antibodies recognize more subtle epitopes induced in PF4 when it binds to CS, the major platelet glycosaminoglycan. Chondroitin Sulfates 192-194 platelet factor 4 Homo sapiens 171-174 27380556-7 2016 Sometimes, HIT antibodies recognize PF4 bound to (platelet-associated) chondroitin sulfate, explaining how HIT might occur without concurrent or recent heparin (delayed-onset HIT, "spontaneous HIT syndrome"). Chondroitin Sulfates 71-90 platelet factor 4 Homo sapiens 36-39 17285619-8 2007 In transgenic mice that vary in expression of human PF4 on their platelets, antigenic complexes form between PF4 and endogenous chondroitin sulfate. Chondroitin Sulfates 128-147 platelet factor 4 Homo sapiens 52-55 21076280-11 2011 It is unclear whether these cases are a result of exposure to a heparin-like proteoglycan such as chondroitin sulfate during surgery that binds PF4, or whether the perioperative pro-inflammatory milieu is the inciting event. Chondroitin Sulfates 98-117 platelet factor 4 Homo sapiens 144-147 20688960-2 2010 Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B. Chondroitin Sulfates 181-200 platelet factor 4 Homo sapiens 129-134 21772054-4 2011 Tetrameric PF4 potentiates aPC generation by formation of complexes with chondroitin sulfate (CS) on TM. Chondroitin Sulfates 73-92 platelet factor 4 Homo sapiens 11-14 21772054-4 2011 Tetrameric PF4 potentiates aPC generation by formation of complexes with chondroitin sulfate (CS) on TM. Chondroitin Sulfates 94-96 platelet factor 4 Homo sapiens 11-14 21772054-9 2011 Our studies provide evidence that complexes formed between PF4 and TM"s CS may play a physiologic role in potentiating aPC generation. Chondroitin Sulfates 72-74 platelet factor 4 Homo sapiens 59-62 20980681-2 2011 We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells. Chondroitin Sulfates 57-76 platelet factor 4 Homo sapiens 14-19 17285619-8 2007 In transgenic mice that vary in expression of human PF4 on their platelets, antigenic complexes form between PF4 and endogenous chondroitin sulfate. Chondroitin Sulfates 128-147 platelet factor 4 Homo sapiens 109-112 11986215-5 2002 Inhibition of internalization and degradation by PF4 required the presence of cell-associated proteoglycans, primarily those rich in chondroitin sulfate. Chondroitin Sulfates 133-152 platelet factor 4 Homo sapiens 49-52 12586630-10 2003 Instead, PF4 may modulate the hematopoietic milieu both directly, by promoting progenitor adhesion and quiescence through interaction with an HPC chondroitin sulfate-containing moiety, and indirectly, by binding to or interfering with signaling caused by other, hematopoietically active chemokines, such as IL-8. Chondroitin Sulfates 146-165 platelet factor 4 Homo sapiens 9-12 15459010-5 2005 Both RANTES-triggered arrest and PF4 binding involved monocytic chondroitin sulfate. Chondroitin Sulfates 64-83 platelet factor 4 Homo sapiens 33-36 9780212-5 1998 Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class. Chondroitin Sulfates 280-299 platelet factor 4 Homo sapiens 13-17 9780212-5 1998 Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class. Chondroitin Sulfates 280-299 platelet factor 4 Homo sapiens 30-34 9780212-5 1998 Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class. Chondroitin Sulfates 280-299 platelet factor 4 Homo sapiens 30-34 8613703-10 1996 Chondroitin sulfate-Sepharose was shown to be equally efficient in retaining PF4 from platelet extracts as serglycin-Sepharose indicating that the glycosaminoglycan chains mediate the binding to PF4 in the intact proteoglycan molecule. Chondroitin Sulfates 0-19 platelet factor 4 Homo sapiens 77-80 8656041-3 1996 We found that binding of iodine 125-labeled PF4 to HEL cells was inhibited by heparin, heparan sulfate, and dermatan sulfate and to a smaller extent by chondroitin sulfate. Chondroitin Sulfates 152-171 platelet factor 4 Homo sapiens 44-47 8613703-10 1996 Chondroitin sulfate-Sepharose was shown to be equally efficient in retaining PF4 from platelet extracts as serglycin-Sepharose indicating that the glycosaminoglycan chains mediate the binding to PF4 in the intact proteoglycan molecule. Chondroitin Sulfates 0-19 platelet factor 4 Homo sapiens 195-198 1689191-6 1990 PF4 was demonstrated in a complex with a separate chondroitin sulfate antigen by crossed immunoelectrophoresis (CIE) experiments in which either anti-PF4 or anti-CS antisera was incorporated in the intermediate gel. Chondroitin Sulfates 50-69 platelet factor 4 Homo sapiens 0-3 1689191-6 1990 PF4 was demonstrated in a complex with a separate chondroitin sulfate antigen by crossed immunoelectrophoresis (CIE) experiments in which either anti-PF4 or anti-CS antisera was incorporated in the intermediate gel. Chondroitin Sulfates 162-164 platelet factor 4 Homo sapiens 0-3