PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17353921-4 2007 The retinoid analogue fenretinide [N-(4-hydroxyphenyl) retinamide] is a new cancer preventive and chemotherapeutic drug, that induces apoptosis of some cancer cell types via oxidative stress, accompanied by induction of an ER stress-related transcription factor, GADD153. Fenretinide 22-33 DNA damage inducible transcript 3 Homo sapiens 263-270 17353921-4 2007 The retinoid analogue fenretinide [N-(4-hydroxyphenyl) retinamide] is a new cancer preventive and chemotherapeutic drug, that induces apoptosis of some cancer cell types via oxidative stress, accompanied by induction of an ER stress-related transcription factor, GADD153. Fenretinide 35-65 DNA damage inducible transcript 3 Homo sapiens 263-270 17273769-4 2007 In this study, we report that fenretinide induces death receptor 5 (DR5)/TRAIL-R2 up-regulation via the induction of the transcription factor CHOP in colon cancer cell lines. Fenretinide 30-41 DNA damage inducible transcript 3 Homo sapiens 142-146 17273769-0 2007 Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines. Fenretinide 0-11 DNA damage inducible transcript 3 Homo sapiens 95-99 17273769-3 2007 Oxidative stress induced by fenretinide has been shown to mediate apoptosis through a mitochondrial pathway by the induction of a transcription factor CCAAT/enhancer binding protein homologous protein (CHOP) and Bak. Fenretinide 28-39 DNA damage inducible transcript 3 Homo sapiens 151-200 17273769-3 2007 Oxidative stress induced by fenretinide has been shown to mediate apoptosis through a mitochondrial pathway by the induction of a transcription factor CCAAT/enhancer binding protein homologous protein (CHOP) and Bak. Fenretinide 28-39 DNA damage inducible transcript 3 Homo sapiens 202-206 17273769-6 2007 Furthermore, fenretinide increased DR5 promoter activity and the enhanced activity decreased by mutation of the CHOP binding site. Fenretinide 13-24 DNA damage inducible transcript 3 Homo sapiens 112-116 17273769-7 2007 CHOP was also up-regulated by fenretinide at the promoter level. Fenretinide 30-41 DNA damage inducible transcript 3 Homo sapiens 0-4 16972258-0 2006 N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153. Fenretinide 0-29 DNA damage inducible transcript 3 Homo sapiens 214-221 16972258-8 2006 Pyrrolidine dithiocarbamate (PDTC), a free-radical scavenger, inhibited 4HPR-induced ROS generation, the expression of its downstream mediator, Gadd153, and apoptosis in the pretreated cells. Fenretinide 72-76 DNA damage inducible transcript 3 Homo sapiens 144-151 15909111-1 2005 Fenretinide induces apoptosis in SH-SY5Y neuroblastoma cells via a signaling pathway involving the production of reactive oxygen species (ROS), 12-lipoxygenase activity and the induction of the GADD153 transcription factor. Fenretinide 0-11 DNA damage inducible transcript 3 Homo sapiens 194-201 15917187-0 2005 ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene. Fenretinide 13-17 DNA damage inducible transcript 3 Homo sapiens 64-71 15917187-4 2005 In 4HPR-treated cells, the elevation of Gadd153 protein level was prevented by vitamin C, which had no effect on the activation of the Gadd153 gene promoter. Fenretinide 3-7 DNA damage inducible transcript 3 Homo sapiens 40-47 15917187-8 2005 The inhibition of 4HPR-induced expression of Gadd153 protein by vitamin C was independent of intracellular proteasome activity and vitamin C had no effect on the intracellular decay of Gadd153 protein. Fenretinide 18-22 DNA damage inducible transcript 3 Homo sapiens 45-52 14645667-3 2003 Because BCL2-family proteins are important in apoptosis induced by chemotherapeutic drugs, GADD153 may be a key mediator of synergy between fenretinide and chemotherapeutic drugs. Fenretinide 140-151 DNA damage inducible transcript 3 Homo sapiens 91-98 14645667-5 2003 Increased expression of GADD153 raised the background level of apoptosis and increased apoptosis induced by fenretinide or the chemotherapeutic drugs cisplatin and etoposide. Fenretinide 108-119 DNA damage inducible transcript 3 Homo sapiens 24-31 14645667-7 2003 Conversely, expression of antisense-GADD153 virtually abolished the induction of apoptosis in response to fenretinide but overall had no significant effect on apoptosis induced by chemotherapeutic drugs. Fenretinide 106-117 DNA damage inducible transcript 3 Homo sapiens 36-43 14645667-8 2003 The effect of antisense-GADD153 on synergy between chemotherapeutic drugs and fenretinide varied with the drug used: there was no effect on synergy between fenretinide and cisplatin, but the combination of fenretinide with etoposide became antagonistic. Fenretinide 78-89 DNA damage inducible transcript 3 Homo sapiens 24-31 14645667-9 2003 These results suggest that mechanisms mediating synergy between fenretinide and chemotherapeutic drugs lie upstream of GADD153. Fenretinide 64-75 DNA damage inducible transcript 3 Homo sapiens 119-126 12939601-3 2003 Previously, we observed that a synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) effectively impaired cell growth and survival (induction of growth arrest and apoptosis) in human hepatoma cells, which was accompanied by over expression of GADD153. Fenretinide 50-79 DNA damage inducible transcript 3 Homo sapiens 245-252 12939601-3 2003 Previously, we observed that a synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) effectively impaired cell growth and survival (induction of growth arrest and apoptosis) in human hepatoma cells, which was accompanied by over expression of GADD153. Fenretinide 81-85 DNA damage inducible transcript 3 Homo sapiens 245-252 12880976-0 2003 Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. Fenretinide 57-68 DNA damage inducible transcript 3 Homo sapiens 13-20 12880976-2 2003 The stress-induced transcription factor GADD153 and the Bcl2-related protein Bak are upregulated in response to fenretinide. Fenretinide 112-123 DNA damage inducible transcript 3 Homo sapiens 40-47 12880976-5 2003 Neither GADD153 or Bak were induced by chemotherapeutic agents but over expression of GADD153 results in increased sensitivity to fenretinide-induced apoptosis. Fenretinide 130-141 DNA damage inducible transcript 3 Homo sapiens 86-93 12880976-6 2003 Therefore, fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterised by the reactive oxygen species-dependent induction of GADD153 and Bak. Fenretinide 11-22 DNA damage inducible transcript 3 Homo sapiens 193-200 12234979-0 2002 GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Fenretinide 36-47 DNA damage inducible transcript 3 Homo sapiens 0-7 12234979-4 2002 Expression of the stress-induced transcription factor, GADD153, was up-regulated at both the protein and mRNA levels in response to fenretinide. Fenretinide 132-143 DNA damage inducible transcript 3 Homo sapiens 55-62 12234979-5 2002 Overexpression of GADD153 increased apoptosis in the presence and absence of fenretinide, whereas reduced expression of GADD153 by expression of antisense DNA abrogated the response to fenretinide. Fenretinide 77-88 DNA damage inducible transcript 3 Homo sapiens 18-25 12234979-5 2002 Overexpression of GADD153 increased apoptosis in the presence and absence of fenretinide, whereas reduced expression of GADD153 by expression of antisense DNA abrogated the response to fenretinide. Fenretinide 185-196 DNA damage inducible transcript 3 Homo sapiens 120-127 12234979-10 2002 These results suggest that fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterized by a fenretinide-dependent increase in 12-LOX activity, leading to the induction of GADD153. Fenretinide 27-38 DNA damage inducible transcript 3 Homo sapiens 239-246 12353227-0 2002 Upregulation of GADD153 expression in the apoptotic signaling of N-(4-hydroxyphenyl)retinamide (4HPR). Fenretinide 65-94 DNA damage inducible transcript 3 Homo sapiens 16-23 12353227-9 2002 In the HeLa cells, both 4HPR and ATRA caused a 2- to 4-fold stimulation of the promoter activity of gadd153, but similar to the CNE3 cells, ATRA was incapable of upregulating the protein level of gadd153. Fenretinide 24-28 DNA damage inducible transcript 3 Homo sapiens 100-107 12138118-0 2002 GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells. Fenretinide 39-68 DNA damage inducible transcript 3 Homo sapiens 0-7 12138118-9 2002 N-Acetyl-l-cysteine or GADD153 antisense significantly protected the cells from 4HPR-induced apoptosis, accompanying by the inhibition of GADD153 overexpression. Fenretinide 80-84 DNA damage inducible transcript 3 Homo sapiens 23-30 12138118-9 2002 N-Acetyl-l-cysteine or GADD153 antisense significantly protected the cells from 4HPR-induced apoptosis, accompanying by the inhibition of GADD153 overexpression. Fenretinide 80-84 DNA damage inducible transcript 3 Homo sapiens 138-145 12234979-10 2002 These results suggest that fenretinide induces apoptosis via RAR-dependent and -independent pathways in which the RAR-independent pathway is characterized by a fenretinide-dependent increase in 12-LOX activity, leading to the induction of GADD153. Fenretinide 160-171 DNA damage inducible transcript 3 Homo sapiens 239-246