PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3115798-1 1987 A selection strategy to obtain cells deficient in poly(ADP-ribose) polymerase was developed based on the fact that treatment with high levels of N-methyl-N"-nitro-N-nitrosoguanidine results in sufficient activation of poly(ADP-ribose) polymerase to cause NAD and ATP depletion leading to cessation of all energy-dependent processes and rapid cell death. Nitrosoguanidines 165-181 poly(ADP-ribose) polymerase 1 Homo sapiens 50-77 3115798-1 1987 A selection strategy to obtain cells deficient in poly(ADP-ribose) polymerase was developed based on the fact that treatment with high levels of N-methyl-N"-nitro-N-nitrosoguanidine results in sufficient activation of poly(ADP-ribose) polymerase to cause NAD and ATP depletion leading to cessation of all energy-dependent processes and rapid cell death. Nitrosoguanidines 165-181 poly(ADP-ribose) polymerase 1 Homo sapiens 218-245