PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28972182-10 2017 uPA-knock-out mice developed fewer and smaller TSC2-null lung tumors, and introduction of uPA shRNA in tumor cells or amiloride-induced uPA inhibition reduced tumorigenesis in vivo These findings suggest that interference with the uPA-dependent pathway, when used along with rapamycin, might attenuate LAM progression and potentially other TSC-related disorders. Amiloride 118-127 TSC complex subunit 1 Mus musculus 47-50