PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32661350-5 2020 We found that fisetin administration significantly alleviated CLP-induced lung, liver and kidney injury, as well as the expression levels of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha and IL-1beta in bronchoalveolar lavage fluid (BALF). fisetin 14-21 tumor necrosis factor Mus musculus 161-194 34354662-18 2021 Further, fisetin administration ameliorated kindling-induced neuroinflammation as evident from decreased levels of HMGB1, TLR-4, IL-1R1, IL-1beta, IL-6, and TNF-alpha in the hippocampus and cortex of the kindled mice. fisetin 9-16 tumor necrosis factor Mus musculus 157-166 35437448-8 2022 Results: Fisetin treatment significantly suppressed ear swelling and associated inflammatory cell infiltration, besides reducing the production of Th17 cytokines (IL-17, TNF-alpha, and IL-6) and the expression of the Th17 lineage transcription factor RORgammat while simultaneously enhancing Treg-specific cytokine production (TGF-beta and IL-10) and the expression of the Treg lineage transcription factor Foxp3, thereby restoring the Th17/Treg cell in ACD mice. fisetin 9-16 tumor necrosis factor Mus musculus 170-179 33870156-10 2021 Fisetin treatment reduced expression of p16 and p21 (80% and 90%, respectively), TNF-alpha (50%), IL-1beta (50%), MCP-1 (70%), and fibrosis (60%) (p >0.05). fisetin 0-7 tumor necrosis factor Mus musculus 81-90 27209403-8 2016 Further neurochemical assays suggested that pretreatment with fisetin reversed LPS-induced overexpression of pro-inflammatory cytokine (IL-1beta, IL-6 and TNF-alpha) in the hippocampus and the prefrontal cortex (PFC). fisetin 62-69 tumor necrosis factor Mus musculus 155-164 31207963-9 2019 Moreover, fisetin treatment inhibited LPS-induced activation of the inflammatory Toll-like Receptors (TLR4)/cluster of differentiation 14 (CD14)/phospho-nuclear factor kappa (NF-kappaB) signaling and attenuated other inflammatory mediators (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL1-beta), and cyclooxygenase (COX-2). fisetin 10-17 tumor necrosis factor Mus musculus 241-268 31207963-9 2019 Moreover, fisetin treatment inhibited LPS-induced activation of the inflammatory Toll-like Receptors (TLR4)/cluster of differentiation 14 (CD14)/phospho-nuclear factor kappa (NF-kappaB) signaling and attenuated other inflammatory mediators (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL1-beta), and cyclooxygenase (COX-2). fisetin 10-17 tumor necrosis factor Mus musculus 270-279 31074472-10 2019 Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), IL-1beta and IL-18, which was attributed to the blockage of nuclear factor kappaB (NF-kappaB) signaling. fisetin 13-16 tumor necrosis factor Mus musculus 173-200 31074472-10 2019 Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), IL-1beta and IL-18, which was attributed to the blockage of nuclear factor kappaB (NF-kappaB) signaling. fisetin 13-16 tumor necrosis factor Mus musculus 202-211 28545670-11 2017 The mRNA levels of IFN-alpha, IFN-lambda, TNF-alpha, Mx, and ZAP were upregulated in RAW 264.7 cells pre-treated with fisetin, quercetin, and daidzein, but not in those pre-treated with EGCG or ECG. fisetin 118-125 tumor necrosis factor Mus musculus 42-51 28213268-10 2017 We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5. fisetin 14-21 tumor necrosis factor Mus musculus 73-82 24706001-9 2014 Fisetin also inhibited the expression and activity of tumor necrosis factor-alpha converting enzyme, induced by PMA in endothelial cells. fisetin 0-7 tumor necrosis factor Mus musculus 54-81 26878795-5 2016 Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues. fisetin 10-17 tumor necrosis factor Mus musculus 111-138 26878795-5 2016 Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues. fisetin 10-17 tumor necrosis factor Mus musculus 140-149 24706001-10 2014 In addition, fisetin inhibited the production of tumor necrosis factor-alpha and the activation of AKT, nuclear factor-kappaB, and extracellular regulated kinases 1/2 by HMGB1 in HUVECs. fisetin 13-20 tumor necrosis factor Mus musculus 49-76 20923145-4 2010 Fisetin suppressed LPS-induced NF-kappaB activation, expression of pro-inflammatory proteins (TNF-alpha and iNOS), MMP-9 activity, and phagocytic activity in macrophages. fisetin 0-7 tumor necrosis factor Mus musculus 94-103 21443976-6 2011 Unexpectedly, Fisetin enhanced and sustained activation of ERK and JNK but not p38 in response to TNFalpha. fisetin 14-21 tumor necrosis factor Mus musculus 98-106 22234339-5 2012 Fisetin also prominently inhibited the infiltration of macrophages and dendritic cells into the ischemic hemisphere and suppressed the intracerebral immune cell activation as measured by intracellular tumor necrosis factor alpha (TNFalpha) production. fisetin 0-7 tumor necrosis factor Mus musculus 201-228 22234339-5 2012 Fisetin also prominently inhibited the infiltration of macrophages and dendritic cells into the ischemic hemisphere and suppressed the intracerebral immune cell activation as measured by intracellular tumor necrosis factor alpha (TNFalpha) production. fisetin 0-7 tumor necrosis factor Mus musculus 230-238 22234339-6 2012 Fisetin also inhibited LPS-induced TNFalpha production and neurotoxicity of macrophages and microglia in vitro by suppressing nuclear factor kappaB activation and JNK/Jun phosphorylation. fisetin 0-7 tumor necrosis factor Mus musculus 35-43 18279803-7 2008 Fisetin also inhibited the gene expression of TNF-alpha, interleukin (IL)-1 beta, cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) at both mRNA and protein levels. fisetin 0-7 tumor necrosis factor Mus musculus 46-55