PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28213268-10	2017	We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5.	fisetin	14-21	interleukin 6	Mus musculus	84-88	
32661350-5	2020	We found that fisetin administration significantly alleviated CLP-induced lung, liver and kidney injury, as well as the expression levels of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha and IL-1beta in bronchoalveolar lavage fluid (BALF).	fisetin	14-21	interleukin 6	Mus musculus	141-159	
31074472-10	2019	Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), IL-1beta and IL-18, which was attributed to the blockage of nuclear factor kappaB (NF-kappaB) signaling.	fisetin	13-16	interleukin 6	Mus musculus	214-227	
31074472-10	2019	Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), IL-1beta and IL-18, which was attributed to the blockage of nuclear factor kappaB (NF-kappaB) signaling.	fisetin	13-16	interleukin 6	Mus musculus	229-233	
27209403-8	2016	Further neurochemical assays suggested that pretreatment with fisetin reversed LPS-induced overexpression of pro-inflammatory cytokine (IL-1beta, IL-6 and TNF-alpha) in the hippocampus and the prefrontal cortex (PFC).	fisetin	62-69	interleukin 6	Mus musculus	146-150	
34354662-18	2021	Further, fisetin administration ameliorated kindling-induced neuroinflammation as evident from decreased levels of HMGB1, TLR-4, IL-1R1, IL-1beta, IL-6, and TNF-alpha in the hippocampus and cortex of the kindled mice.	fisetin	9-16	interleukin 6	Mus musculus	147-151	
26878795-5	2016	Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues.	fisetin	10-17	interleukin 6	Mus musculus	186-199	
26878795-5	2016	Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues.	fisetin	10-17	interleukin 6	Mus musculus	201-205	
35437448-8	2022	Results: Fisetin treatment significantly suppressed ear swelling and associated inflammatory cell infiltration, besides reducing the production of Th17 cytokines (IL-17, TNF-alpha, and IL-6) and the expression of the Th17 lineage transcription factor RORgammat while simultaneously enhancing Treg-specific cytokine production (TGF-beta and IL-10) and the expression of the Treg lineage transcription factor Foxp3, thereby restoring the Th17/Treg cell in ACD mice.	fisetin	9-16	interleukin 6	Mus musculus	185-189