PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27158416-0 2016 Promising tumor inhibiting potentials of Fisetin through PI3K/AKT/mTOR pathway. fisetin 41-48 AKT serine/threonine kinase 1 Homo sapiens 62-65 26590114-10 2015 Moreover, fisetin increased Akt phosphorylation and a PI3K pathway inhibitor (LY294002) abolished fisetin-induced cytoprotection and NO inhibition. fisetin 10-17 AKT serine/threonine kinase 1 Homo sapiens 28-31 24675012-11 2014 Our studies characterized, for the first time, the differential interactions of any botanical agent with kinases involved in melanoma growth and demonstrate that fisetin inhibits mTOR and p70S6K through direct binding while the observed inhibitory effect of fisetin on AKT is mediated indirectly, through targeting interrelated pathways. fisetin 162-169 AKT serine/threonine kinase 1 Homo sapiens 269-272 26590114-0 2015 Fisetin inhibits TNF-alpha-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 149-152 21618507-4 2012 In the present study, we show that fisetin, a dietary tetrahydroxyflavone inhibits cell growth with the concomitant suppression of PI3K/Akt and mTOR signaling in human nonsmall cell lung cancer (NSCLC) cells. fisetin 35-42 AKT serine/threonine kinase 1 Homo sapiens 136-139 24675012-11 2014 Our studies characterized, for the first time, the differential interactions of any botanical agent with kinases involved in melanoma growth and demonstrate that fisetin inhibits mTOR and p70S6K through direct binding while the observed inhibitory effect of fisetin on AKT is mediated indirectly, through targeting interrelated pathways. fisetin 258-265 AKT serine/threonine kinase 1 Homo sapiens 269-272 23538677-5 2013 Moreover, fisetin-treated OCLs showed markedly decreased phosphorylation of extracellular signal-regulated kinase, Akt, and Jun N-terminal kinase, but fisetin did not inhibit p38 phosphorylation. fisetin 10-17 AKT serine/threonine kinase 1 Homo sapiens 115-118 21618507-7 2012 Treatment of cells with fisetin caused decrease in the protein expression of PI3K (p85 and p110), inhibition of phosphorylation of Akt, mTOR, p70S6K1, eIF-4E and 4E-BP1. fisetin 24-31 AKT serine/threonine kinase 1 Homo sapiens 131-134 21618507-11 2012 Our results show that fisetin suppressed PI3K/Akt and mTOR signaling in NSCLC cells and thus, could be developed as a chemotherapeutic agent against human lung cancer. fisetin 22-29 AKT serine/threonine kinase 1 Homo sapiens 46-49 34695518-0 2021 Fisetin-induced PTEN expression reverses cellular senescence by inhibiting the mTORC2-Akt Ser473 phosphorylation pathway in vascular smooth muscle cells. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 86-89 20637980-8 2010 By contrast, both phospho-AKT and phospho-ERK1/2, which are involved in cell proliferation and antiapoptotic pathways, were suppressed after irradiation combined with fisetin pretreatment. fisetin 167-174 AKT serine/threonine kinase 1 Homo sapiens 26-29 20530556-5 2010 Fisetin also activated the mTOR repressor TSC2 through inhibition of Akt and activation of AMPK. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 69-72 19633975-4 2010 Our result also showed that fisetin could inhibit the phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) and Akt. fisetin 28-35 AKT serine/threonine kinase 1 Homo sapiens 118-121 19633975-8 2010 These results showed fisetin could inhibit the metastatic ability of PC-3 by reducing MMP-2 and MMP-9 expressions through suppressing phosphoinositide 3-kinase/Akt (PI3K/Akt) and JNK signaling pathways. fisetin 21-28 AKT serine/threonine kinase 1 Homo sapiens 160-163 33086879-0 2021 Fisetin Inhibits Autophagy in HepG2 Cells via PI3K/Akt/mTOR and AMPK Pathway. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 51-54 34821587-0 2021 Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 98-101 33086879-7 2021 In the Western blotting analysis, fisetin treatment inhibited the expression of Atg7, Atg16L, mTOR, and pACC and elevated the expression of Atg5, AMPKalpha, AMPKbeta1/2, ACC and Akt. fisetin 34-41 AKT serine/threonine kinase 1 Homo sapiens 178-181 33086879-8 2021 Taken together, the results revealed that fisetin inhibited autophagy by the activation of PI3K/Akt/mTOR and modulation of AMPK signaling pathways. fisetin 42-49 AKT serine/threonine kinase 1 Homo sapiens 96-99 30468635-5 2019 Moreover, fisetin attenuated rotenone induced toxicity by down-regulating Bax, caspases-3 protein expression and up-regulating protein expression of Bcl-2, p38/JNK-MAPK and PI3K, Akt, GSK-3beta pathways. fisetin 10-17 AKT serine/threonine kinase 1 Homo sapiens 179-182 32257052-2 2020 We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) efficiently downregulated pro-tumor cytokines released by HCC through inhibition of Akt/mTOR/RPS6 phospho-signaling. fisetin 119-126 AKT serine/threonine kinase 1 Homo sapiens 217-220 32257052-2 2020 We have previously shown by network analysis of proteomic data that the flavonoids epigallocatechin gallate (EGCG) and fisetin (FIS) efficiently downregulated pro-tumor cytokines released by HCC through inhibition of Akt/mTOR/RPS6 phospho-signaling. fisetin 128-131 AKT serine/threonine kinase 1 Homo sapiens 217-220 31540162-0 2019 Fisetin, a 3,7,3",4"-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 59-62 31540162-0 2019 Fisetin, a 3,7,3",4"-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models. fisetin 11-40 AKT serine/threonine kinase 1 Homo sapiens 59-62 31540162-5 2019 Fisetin treatment of NHEKs dose- and time-dependently induced differentiation and inhibited interleukin-22-induced proliferation, as well as activation of the PI3K/Akt/mTOR pathway. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 164-167 30431692-0 2019 Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 109-112 30431692-5 2019 Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its half-life, decreasing enolase phosphorylation, and alteration of phosphatidylinositol 3-kinase/Akt signaling. fisetin 26-33 AKT serine/threonine kinase 1 Homo sapiens 276-279 29204750-9 2018 These results indicate that fisetin protects 6-OHDA-induced cell death by activating PI3K-Akt signaling in human neuronal SH-SY5Y cells. fisetin 28-35 AKT serine/threonine kinase 1 Homo sapiens 90-93 29296070-9 2017 Fisetin combined with LY294002 (an inhibitor of AKT) prevented the EGF-induced migration involved in downregulation of Sp1 and MMP-9 expression. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 48-51 29296070-11 2017 Conclusions: Fisetin inhibited EGF-induced cell migration via modulation of AKT/Sp1-dependent MMP-9 transcriptional activity. fisetin 13-20 AKT serine/threonine kinase 1 Homo sapiens 76-79 28204814-6 2017 Fisetin also decreased the phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk)1/2, but had no effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK). fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 53-56 28204814-7 2017 These results indicate that fisetin inhibits aggressive cell phenotypes by suppressing cell migration and proliferation via the Akt/Erk signaling pathway. fisetin 28-35 AKT serine/threonine kinase 1 Homo sapiens 128-131 27904686-0 2016 Fisetin, a dietary phytochemical, overcomes Erlotinib-resistance of lung adenocarcinoma cells through inhibition of MAPK and AKT pathways. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 125-128 27904686-7 2016 As expected, the results showed that Fisetin effectively increased sensitivity of Erlotinib-resistant lung cancer cells to Erlotinib, possibly by inhibiting aberrant activation of MAPK and AKT signaling pathways resulted from AXL suppression. fisetin 37-44 AKT serine/threonine kinase 1 Homo sapiens 189-192 27551764-0 2016 Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-kappaB/mTOR and ERK1/2 signaling pathways. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 59-62 27551764-5 2016 In our study, flow cytometry and western blot assays suggested that apoptosis was induced by fisetin administration, promoting Caspase-3 expressions by regulating PI3K/AKT/NF-kappaB. fisetin 93-100 AKT serine/threonine kinase 1 Homo sapiens 168-171 29574877-7 2018 Western blot assays suggested that apoptosis was induced by fisetin administration, promoting Caspase-8, and Cytochrome-C expressions possibly by inhibiting aberrant activation of IGF1R and AKT proteins. fisetin 60-67 AKT serine/threonine kinase 1 Homo sapiens 190-193 30108501-0 2018 Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3beta Signal Pathway. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 132-135 30108501-6 2018 Furthermore, fisetin suppressed phosphoinositol 3-kinase (PI3K)-Akt-GSK-3beta signaling pathway but upregulated the expression of PTEN mRNA and protein in a concentration-dependent manner. fisetin 13-20 AKT serine/threonine kinase 1 Homo sapiens 64-67 30108501-8 2018 In vivo, using the metastatic breast cancer xenograft model bearing MDA-MB-231 cells, we found that fisetin dramatically inhibited growth of primary breast tumor and reduced lung metastasis, meanwhile, the expression of EMT molecules and PTEN/Akt/GSK-3beta in primary and metastatic tissues changed in the same way as those in vitro experiments. fisetin 100-107 AKT serine/threonine kinase 1 Homo sapiens 243-246 30108501-9 2018 In conclusion, all these results indicated that fisetin could effectively suppress proliferation and metastasis of TNBC and reverse EMT process, which might be mediated by PTEN/Akt/GSK-3beta signaling pathway. fisetin 48-55 AKT serine/threonine kinase 1 Homo sapiens 177-180 29204750-0 2018 Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells. fisetin 22-29 AKT serine/threonine kinase 1 Homo sapiens 85-88 29204750-8 2018 Furthermore, fisetin activated the PI3K-Akt signaling, which inhibits the caspase cascade, and fisetin-mediated inhibition of 6-OHDA-induced cell death was negated by the co-treatment with an Akt inhibitor. fisetin 13-20 AKT serine/threonine kinase 1 Homo sapiens 40-43 29204750-8 2018 Furthermore, fisetin activated the PI3K-Akt signaling, which inhibits the caspase cascade, and fisetin-mediated inhibition of 6-OHDA-induced cell death was negated by the co-treatment with an Akt inhibitor. fisetin 13-20 AKT serine/threonine kinase 1 Homo sapiens 192-195 29204750-8 2018 Furthermore, fisetin activated the PI3K-Akt signaling, which inhibits the caspase cascade, and fisetin-mediated inhibition of 6-OHDA-induced cell death was negated by the co-treatment with an Akt inhibitor. fisetin 95-102 AKT serine/threonine kinase 1 Homo sapiens 192-195 29296070-0 2017 Fisetin inhibits epidermal growth factor-induced migration of ARPE-19 cells by suppression of AKT activation and Sp1-dependent MMP-9 expression. fisetin 0-7 AKT serine/threonine kinase 1 Homo sapiens 94-97