PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18591783-6	2008	Apigenin, luteolin, kaempferol, quercetin and fisetin also appeared to inhibit insulin-stimulated activation of Akt, a pivotal downstream effector of phosphatidylinositol 3-kinase (PI3K), and suppressed insulin-dependent translocation of a glucose transporter, (GLUT)4, into the plasma membrane.	fisetin	46-53	thymoma viral proto-oncogene 1	Mus musculus	112-115	
33645479-0	2021	Connectivity map analysis identifies fisetin as a treatment compound for osteoporosis through activating the PI3K-AKT signaling pathway in mouse pre-osteoblastic MC3T3-E1 cells.	fisetin	37-44	thymoma viral proto-oncogene 1	Mus musculus	114-117	
34695518-7	2021	In mouse aortas, fisetin delayed aging by regulating the PTEN-mTORC2-Akt (Ser473) signaling pathway.	fisetin	17-24	thymoma viral proto-oncogene 1	Mus musculus	69-72	
34354662-20	2021	Decreased phosphorylation of the AkT/mTOR pathway was reported with fisetin administration in the hippocampus and cortex of the kindled mice.	fisetin	68-75	thymoma viral proto-oncogene 1	Mus musculus	33-36	
33841067-0	2021	Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.	fisetin	0-7	thymoma viral proto-oncogene 1	Mus musculus	70-73	
33841067-6	2021	In addition, fisetin reduced the elevated expression of p-PI3K, p-AKT and p-mTOR induced by LPS in a concentration-dependent manner.	fisetin	13-20	thymoma viral proto-oncogene 1	Mus musculus	66-69	
33645479-12	2021	CONCLUSION: Our results demonstrated that fisetin could promote MC3T3-E1 cell proliferation, differentiation, and increase OPG/RANKL expression ratio through activating the PI3K-AKT pathway, which has potential in the treatment of osteoporosis.	fisetin	42-49	thymoma viral proto-oncogene 1	Mus musculus	178-181	
32265642-0	2020	Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway.	fisetin	0-7	thymoma viral proto-oncogene 1	Mus musculus	77-80	
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	fisetin	154-161	thymoma viral proto-oncogene 1	Mus musculus	85-88	
32265642-12	2020	These findings indicate that fisetin has potent neuroprotective effect and prevents HG-induced neurotoxicity by activation of PI3K/Akt/CREB pathway.	fisetin	29-36	thymoma viral proto-oncogene 1	Mus musculus	131-134	
25169110-8	2015	Further studies revealed that fisetin inhibited UVB-induced expression of PI3K, phosphorylation of AKT and activation of the NFkappaB signaling pathway in mouse skin.	fisetin	30-37	thymoma viral proto-oncogene 1	Mus musculus	99-102	
31018249-5	2019	Treatment of PIK3CA-mutant cells with fisetin and 5-FU reduced the expression of PI3K, phosphorylation of AKT, mTOR, its target proteins, constituents of mTOR signaling complex and this treatment increased the phosphorylation of AMPKalpha.	fisetin	38-45	thymoma viral proto-oncogene 1	Mus musculus	106-109	
25169110-0	2015	Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFkappaB signaling pathways in SKH-1 hairless mice.	fisetin	0-7	thymoma viral proto-oncogene 1	Mus musculus	75-78	
25169110-2	2015	In this study, we investigated whether fisetin reduces inflammatory responses and modulates PI3K/AKT/NFkappaB cell survival signaling pathways in UVB-exposed SKH-1 hairless mouse skin.	fisetin	39-46	thymoma viral proto-oncogene 1	Mus musculus	97-100	
29749427-0	2018	Anti-cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies.	fisetin	23-30	thymoma viral proto-oncogene 1	Mus musculus	85-88	
26878795-6	2016	Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice.	fisetin	30-37	thymoma viral proto-oncogene 1	Mus musculus	205-208	
26878795-9	2016	These results suggest that fisetin exerts anti-inflammatory activity via inhibition of Akt, p38 MAPK and NF-kappaB signaling in the colon tissues of DSS-exposed mice.	fisetin	27-34	thymoma viral proto-oncogene 1	Mus musculus	87-90	
24675012-7	2014	Further studies in melanoma cultures and mouse xenografts showed that fisetin-mediated growth inhibition was associated with dephosphorylation of AKT, mTOR and p70S6K proteins.	fisetin	70-77	thymoma viral proto-oncogene 1	Mus musculus	146-149	
23517912-6	2013	The results suggested that fisetin treatment inhibits mTORC1 activity in an Akt-dependent manner.	fisetin	27-34	thymoma viral proto-oncogene 1	Mus musculus	76-79	
23517912-11	2013	We also observed that fisetin efficiently suppressed the phosphorylation of Akt, S6K1 and mTORC1 in adipose tissue.	fisetin	22-29	thymoma viral proto-oncogene 1	Mus musculus	76-79