PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15100171-7	2004	We also determined, for comparison, two common bioflavonoids (quercetin and fisetin) for their inhibitory effects on human liver COMT-mediated O-methylation of catechol estrogens.	fisetin	76-83	catechol-O-methyltransferase	Homo sapiens	129-133	
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	fisetin	111-118	catechol-O-methyltransferase	Homo sapiens	193-197	
31258092-8	2019	Among these active COMT inhibitors only morin (IC50 = 16.2 microM), alizarin (IC50 = 8.16 microM) and fisetin (IC50 = 7.33 microM) were noteworthy MAO inhibitors, with specificity for MAO-A.	fisetin	102-109	catechol-O-methyltransferase	Homo sapiens	19-23	
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	fisetin	14-21	catechol-O-methyltransferase	Homo sapiens	149-178	
29168878-1	2018	Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins.	fisetin	14-21	catechol-O-methyltransferase	Homo sapiens	180-184	
29168878-8	2018	The results indicate that quercetin or fisetin is superior to ECs for methylation by COMT.	fisetin	39-46	catechol-O-methyltransferase	Homo sapiens	85-89	
27826992-5	2017	Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens.	fisetin	111-118	catechol-O-methyltransferase	Homo sapiens	307-311	
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	fisetin	115-122	catechol-O-methyltransferase	Homo sapiens	140-168	
27522262-0	2016	Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells: Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT).	fisetin	115-122	catechol-O-methyltransferase	Homo sapiens	170-174	
27522262-7	2016	(2) Inhibition of catechol-O-methyltransferase enzyme by entacapone decreased the antiproliferative effects of fisetin and quercetin.	fisetin	111-118	catechol-O-methyltransferase	Homo sapiens	18-46