PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29568876-9	2018	In fisetin-treated animals, pro-inflammatory cytokine release was downregulated accompanied with TLR4/NF-kappaB inactivation.	fisetin	3-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111	
33429334-0	2021	Fisetin protects against high fat diet-induced nephropathy by inhibiting inflammation and oxidative stress via the blockage of iRhom2/NF-kappaB signaling.	fisetin	0-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143	
31074472-10	2019	Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), IL-1beta and IL-18, which was attributed to the blockage of nuclear factor kappaB (NF-kappaB) signaling.	fisetin	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	319-328	
29568921-0	2018	Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-kappaB signaling pathway.	fisetin	0-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85	
29568921-6	2018	Whether fisetin treatment attenuated OVA-induced airway inflammation was examined via inflammation inhibition through MyD88-related NF-kappaB (p65) signaling pathway.	fisetin	8-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141	
29568921-9	2018	In contrast, fisetin-treated mice after OVA induction inhibited activation of MyD88 and NF-kappaB signaling pathways, resulting in downregulation of pro-inflammatory cytokine secretion.	fisetin	13-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97	
27209403-9	2016	Moreover, higher dose of fisetin effectively antagonized iNOS mRNA expression and nitrite levels via the modulation of NF-kappaB in the hippocampus and PFC.	fisetin	25-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128	
29587289-11	2018	NF-kappaB signaling was also attenuated by fisetin treatment.	fisetin	43-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9	
26878795-0	2016	Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-kappaB signaling.	fisetin	0-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94	
26878795-6	2016	Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice.	fisetin	30-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139	
26878795-9	2016	These results suggest that fisetin exerts anti-inflammatory activity via inhibition of Akt, p38 MAPK and NF-kappaB signaling in the colon tissues of DSS-exposed mice.	fisetin	27-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114	
26878795-6	2016	Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice.	fisetin	30-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76	
25169110-0	2015	Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFkappaB signaling pathways in SKH-1 hairless mice.	fisetin	0-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-87	
25169110-2	2015	In this study, we investigated whether fisetin reduces inflammatory responses and modulates PI3K/AKT/NFkappaB cell survival signaling pathways in UVB-exposed SKH-1 hairless mouse skin.	fisetin	39-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-109	
25169110-8	2015	Further studies revealed that fisetin inhibited UVB-induced expression of PI3K, phosphorylation of AKT and activation of the NFkappaB signaling pathway in mouse skin.	fisetin	30-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-133	
22239491-0	2012	Inhibition of c-Jun N-terminal kinase and nuclear factor kappa B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells.	fisetin	83-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-64	
22239491-5	2012	Furthermore, fisetin suppressed the activation of nuclear factor kappa B (NF-kappaB) and the phosphorylation of c-Jun N-terminal kinase (JNK), but not extracellular signal regulated kinase (ERK) and p38 MAPK in LPS-treated RAW264.7 cells.	fisetin	13-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-72	
22239491-5	2012	Furthermore, fisetin suppressed the activation of nuclear factor kappa B (NF-kappaB) and the phosphorylation of c-Jun N-terminal kinase (JNK), but not extracellular signal regulated kinase (ERK) and p38 MAPK in LPS-treated RAW264.7 cells.	fisetin	13-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83