PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19037088-6	2009	We found that the treatment of COX2-overexpressing HT29 human colon cancer cells with fisetin (30-120 microM) resulted in induction of apoptosis, downregulation of COX2 protein expression without affecting COX1 and inhibited the secretion of prostaglandin E2.	fisetin	86-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	31-35	
34864006-0	2022	Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells through regulating COX-2/MMPs/beta-catenin pathway.	fisetin	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139	
34864006-4	2022	Further, fisetin, a bioflavonoid, exhibits antioxidant and anti-inflammatory properties, but its effect in modulating COX-2-mediated inflammation and downstream sequelae remains unexplored.	fisetin	9-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	118-123	
33616827-8	2021	Fisetin treatment alleviated cell injury and suppressed the inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), interleukin-16 (IL-6), and prostaglandin E2 (PGE2)) and antioxidant parameters in a dose-dependent manner.	fisetin	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	218-234	
33616827-8	2021	Fisetin treatment alleviated cell injury and suppressed the inflammatory cytokines (interleukin-1 (IL-1), tumor necrosis factor- alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), interleukin-16 (IL-6), and prostaglandin E2 (PGE2)) and antioxidant parameters in a dose-dependent manner.	fisetin	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241	
33616827-10	2021	Fisetin significantly (P < 0.001) suppressed the neurological parameters and inflammatory cytokines such as IL-1, TNF-alpha, iNOS, IL-1beta, COX-2, IL-6, PGE2, and oxidative markers in a dose-dependent manner.	fisetin	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	141-146	
25263652-6	2014	The data indicate that fisetin inhibits MAPK activation and COX-2 expression without affecting cell viability.	fisetin	23-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	60-65	
25882230-4	2015	The results revealed that 5-25 muM fisetin inhibits cyclooxygenase-2 (COX-2) and matrix metalloproteinase (MMP)-1, MMP-3, MMP-9 expression induced by ultraviolet B (UVB) irradiation in human skin fibroblasts.	fisetin	35-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-68	
25882230-4	2015	The results revealed that 5-25 muM fisetin inhibits cyclooxygenase-2 (COX-2) and matrix metalloproteinase (MMP)-1, MMP-3, MMP-9 expression induced by ultraviolet B (UVB) irradiation in human skin fibroblasts.	fisetin	35-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75	
19037088-6	2009	We found that the treatment of COX2-overexpressing HT29 human colon cancer cells with fisetin (30-120 microM) resulted in induction of apoptosis, downregulation of COX2 protein expression without affecting COX1 and inhibited the secretion of prostaglandin E2.	fisetin	86-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	164-168