PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28181380-5	2017	Results indicate that fisetin induced cell death through the cell morphological changes, caused G2/M phase arrest, induction of apoptosis, promoted ROS and Ca2+ production, and decreased the level of DeltaPsim and increased caspase-3, -8, and -9 activities in SCC-4 cells.	fisetin	22-29	caspase 3	Homo sapiens	224-245	
28440400-7	2017	Caspase-3 signaling pathway was promoted in carnosic acid and fisetin co-treatment, which was accompanied by anti-apoptotic proteins of Bcl-2 and Bcl-xl decreasing and pro-apoptotic signals of Bax and Bad increasing.	fisetin	62-69	caspase 3	Homo sapiens	0-9	
29204750-7	2018	Moreover, fisetin effectively suppressed 6-OHDA-mediated activation of caspase-3 and caspase-9, which leads to the cell death, while, 6-OHDA-induced caspase-3/7 activity was lowered.	fisetin	10-17	caspase 3	Homo sapiens	71-80	
29204750-7	2018	Moreover, fisetin effectively suppressed 6-OHDA-mediated activation of caspase-3 and caspase-9, which leads to the cell death, while, 6-OHDA-induced caspase-3/7 activity was lowered.	fisetin	10-17	caspase 3	Homo sapiens	149-158	
27551764-5	2016	In our study, flow cytometry and western blot assays suggested that apoptosis was induced by fisetin administration, promoting Caspase-3 expressions by regulating PI3K/AKT/NF-kappaB.	fisetin	93-100	caspase 3	Homo sapiens	127-136	
26662956-0	2016	Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway.	fisetin	22-29	caspase 3	Homo sapiens	148-157	
26662956-7	2016	Our study showed that the combination of fisetin and sorafenib exerted better synergistic effects in vitro and in vivo than either agent used alone against human cervical cancer, and this synergism was based on apoptotic potential through a mitochondrial- and DR5-dependent caspase-8/caspase-3 signaling pathway.	fisetin	41-48	caspase 3	Homo sapiens	284-293	
21964635-0	2012	Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway.	fisetin	0-7	caspase 3	Homo sapiens	111-120	
25381036-4	2015	Moreover, fisetin significantly modulated the expression of apoptosis-associated proteins, resulting in reduced expression of B cell lymphoma-2, increased expression of Bcl-2-associated X protein, and activation of caspase-9 and caspase-3.	fisetin	10-17	caspase 3	Homo sapiens	229-238	
22261340-3	2012	Fisetin enhanced caspase-3 activation, downregulation of Bcl-2 and Mcl-1(L), and upregulation of Bax, Bim and Bad.	fisetin	0-7	caspase 3	Homo sapiens	17-26	
21964635-4	2012	In addition, fisetin triggered the activations of caspases-3 and -8 and the cleavages of poly (ADP-ribose) polymerase, resulting in apoptosis induction.	fisetin	13-20	caspase 3	Homo sapiens	50-67	
22139440-5	2012	Fisetin-caused cell death was accompanied by decreased expression of survivin and an increase in cleaved levels of caspases-3 and -7 and poly-(ADP-ribose) polymerase along with an increased ratio of Bax to Bcl-2.	fisetin	0-7	caspase 3	Homo sapiens	115-132	
18359761-7	2008	Treatment of cells with fisetin also resulted in significant activation of caspases-3, -8 and -9.	fisetin	24-31	caspase 3	Homo sapiens	75-96	
21922137-5	2012	We found fisetin can trigger a             novel form of atypical apoptosis in caspase-3-deficient MCF-7 cells, which was             characterized by several apoptotic features, including plasma membrane rupture,             mitochondrial depolarization, activation of caspase-7, -8 and -9, and PARP cleavage;             however, neither DNA fragmentation and phosphotidylserine (PS) externalization             was observed.	fisetin	9-16	caspase 3	Homo sapiens	79-88	
20974518-3	2011	Fisetin-induced apoptosis in HCT116 cells as indicated by TUNEL assay, Annexin V-FITC/PI double staining, Ser15-phosphorylation of p53, and cleavages of procaspase-3 and PARP.	fisetin	0-7	caspase 3	Homo sapiens	153-165	
19264955-9	2009	Additionally, fisetin caused an increase in the protein levels of cleaved caspase-8, Fas ligand, death receptor 5, and TNF-related apoptosis-inducing ligand, and the caspase-8 inhibitor Z-IETD-FMK suppressed fisetin-induced apoptosis and the activation of caspase-3.	fisetin	14-21	caspase 3	Homo sapiens	256-265	
31634424-11	2020	Fisetin reduced the expression of Bcl2, and elevated levels of Bax, caspase-3, and PARP and thus induced apoptosis in HepG2 cells.	fisetin	0-7	caspase 3	Homo sapiens	68-77	
29848706-3	2018	Meterials and Methods: Cytotoxic effect of fisetin in combination with gemcitabine on MiaPaca-2 cells was evaluated by the MTT assay, caspase 3/7 assay and propidium iodide/Annexin V.	fisetin	43-50	caspase 3	Homo sapiens	134-143