PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33716741-6	2021	Conversely, Fisetin prevented the D-gal-mediated ROS accumulation, by regulating the endogenous anti-oxidant mechanisms, such as Sirt1/Nrf2 signaling, suppressed the activated p-JNK/NF-kB pathway, and its downstream targets, such as inflammatory cytokines.	fisetin	12-19	sirtuin 1	Mus musculus	129-134	
31539617-9	2019	Moreover, fisetin can increase levels of the denosine 5"-monophosphate-activated protein kinase (AMPK) phosphorylation and SIRT1.	fisetin	10-17	sirtuin 1	Mus musculus	123-128	
30340832-0	2018	Corrigendum to "Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells" [Biochem.	fisetin	16-23	sirtuin 1	Mus musculus	32-37	
30235452-9	2018	Fisetin treatment also reduced liver lipid droplet and hepatocyte steatosis, alleviated serum free fatty acid, and leptin concentrations, significantly decreased fatty acid synthase, and significantly increased phosphorylation of AMPKalpha and the production of sirt-1 and carnitine palmitoyltransferase I in the liver tissue.	fisetin	0-7	sirtuin 1	Mus musculus	262-268	
30235452-11	2018	CONCLUSION: This study suggests that fisetin is a potential novel treatment for alleviating hepatic lipid metabolism and improving NAFLD in mice via activation of the sirt1/AMPK and beta-oxidation pathway.	fisetin	37-44	sirtuin 1	Mus musculus	167-172	
26499075-0	2015	Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells.	fisetin	0-7	sirtuin 1	Mus musculus	16-21	
26499075-5	2015	Depletion of Sirt1 abolished the inhibitory effects of fisetin on intracellular lipid accumulation and on PPARgamma expression.	fisetin	55-62	sirtuin 1	Mus musculus	13-18	
28213268-12	2017	Furthermore, fisetin significantly inhibited IL-1beta-induced SIRT1 decrease and inactivation.	fisetin	13-20	sirtuin 1	Mus musculus	62-67	
28213268-13	2017	However, the inhibitory effect of fisetin was obvious abolished by sirtinol, suggesting that fisetin exerts anti-inflammatory effects through activating SIRT1.	fisetin	34-41	sirtuin 1	Mus musculus	153-158	
28213268-13	2017	However, the inhibitory effect of fisetin was obvious abolished by sirtinol, suggesting that fisetin exerts anti-inflammatory effects through activating SIRT1.	fisetin	93-100	sirtuin 1	Mus musculus	153-158