PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31044527-0	2019	Fisetin activates Hippo pathway and JNK/ERK/AP-1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression.	fisetin	0-7	mitogen-activated protein kinase 8	Homo sapiens	36-39	
31540162-6	2019	Fisetin treatment of TNF-alpha stimulated NHEKs also significantly inhibited the activation of p38 and JNK, but had enhanced effect on ERK1/2 (MAPK).	fisetin	0-7	mitogen-activated protein kinase 8	Homo sapiens	103-106	
31044527-9	2019	In this study, we found that fisetin can upregulate ZAK expression to induce the Hippo pathway and mediate the activation of JNK/ERK, the downstream of ZAK, to trigger cell apoptosis via AP-1 dependent manner in human OS cells.	fisetin	29-36	mitogen-activated protein kinase 8	Homo sapiens	125-128	
23861901-8	2013	We further showed that fisetin inhibits the constitutive proteasomal degradation of MKP-1, the phosphatase that deactivates p38 and JNK.	fisetin	23-30	mitogen-activated protein kinase 8	Homo sapiens	132-135	
19633975-4	2010	Our result also showed that fisetin could inhibit the phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) and Akt.	fisetin	28-35	mitogen-activated protein kinase 8	Homo sapiens	73-104	
19633975-4	2010	Our result also showed that fisetin could inhibit the phosphorylation of c-Jun N-terminal kinase 1 and 2 (JNK1/2) and Akt.	fisetin	28-35	mitogen-activated protein kinase 8	Homo sapiens	106-112	
19633975-8	2010	These results showed fisetin could inhibit the metastatic ability of PC-3 by reducing MMP-2 and MMP-9 expressions through suppressing phosphoinositide 3-kinase/Akt (PI3K/Akt) and JNK signaling pathways.	fisetin	21-28	mitogen-activated protein kinase 8	Homo sapiens	179-182	
26797785-6	2016	In addition, fisetin induced phosphorylation of ERK, JNK, and p38 MAPK.	fisetin	13-20	mitogen-activated protein kinase 8	Homo sapiens	53-56	
23538677-5	2013	Moreover, fisetin-treated OCLs showed markedly decreased phosphorylation of extracellular signal-regulated kinase, Akt, and Jun N-terminal kinase, but fisetin did not inhibit p38 phosphorylation.	fisetin	10-17	mitogen-activated protein kinase 8	Homo sapiens	124-145	
18949064-9	2008	Fisetin also inhibited UVB-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied.	fisetin	0-7	mitogen-activated protein kinase 8	Homo sapiens	66-89	
18949064-9	2008	Fisetin also inhibited UVB-induced phosphorylation of the p38 and c-Jun N-terminal kinase (JNK) proteins of the MAPK family at various time points studied.	fisetin	0-7	mitogen-activated protein kinase 8	Homo sapiens	91-94