PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19264955-6	2009	Fisetin induced a reduction in the protein levels of antiapoptotic Bcl-xL and Bcl-2 and an increase in the levels of proapoptotic Bak and Bim.	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	78-83	
32521901-11	2020	The growth inhibitory effects of Fisetin were mainly due to induction of apoptosis which was accompanied by enhancement of the capsase-3 and Bax and depletion of Bcl-2 expression.	fisetin	33-40	BCL2 apoptosis regulator	Homo sapiens	162-167	
30468635-5	2019	Moreover, fisetin attenuated rotenone induced toxicity by down-regulating Bax, caspases-3 protein expression and up-regulating protein expression of Bcl-2, p38/JNK-MAPK and PI3K, Akt, GSK-3beta pathways.	fisetin	10-17	BCL2 apoptosis regulator	Homo sapiens	149-154	
22139440-5	2012	Fisetin-caused cell death was accompanied by decreased expression of survivin and an increase in cleaved levels of caspases-3 and -7 and poly-(ADP-ribose) polymerase along with an increased ratio of Bax to Bcl-2.	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	206-211	
31634424-11	2020	Fisetin reduced the expression of Bcl2, and elevated levels of Bax, caspase-3, and PARP and thus induced apoptosis in HepG2 cells.	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	34-38	
29383865-8	2018	Fisetin inhibited antiapoptotic Bcl-2 family proteins and damaged the mitochondrial transmembrane potential.	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	32-37	
28440400-7	2017	Caspase-3 signaling pathway was promoted in carnosic acid and fisetin co-treatment, which was accompanied by anti-apoptotic proteins of Bcl-2 and Bcl-xl decreasing and pro-apoptotic signals of Bax and Bad increasing.	fisetin	62-69	BCL2 apoptosis regulator	Homo sapiens	136-141	
25381036-4	2015	Moreover, fisetin significantly modulated the expression of apoptosis-associated proteins, resulting in reduced expression of B cell lymphoma-2, increased expression of Bcl-2-associated X protein, and activation of caspase-9 and caspase-3.	fisetin	10-17	BCL2 apoptosis regulator	Homo sapiens	169-174	
22261340-3	2012	Fisetin enhanced caspase-3 activation, downregulation of Bcl-2 and Mcl-1(L), and upregulation of Bax, Bim and Bad.	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	57-62	
18359761-5	2008	Fisetin treatment also resulted in induction of apoptosis, poly (ADP-ribose) polymerase (PARP) cleavage, modulation in the expressions of Bcl-2 family proteins, inhibition of phosphatidyl inositol 3-kinase and phosphorylation of Akt at Ser(473) and Thr(308).	fisetin	0-7	BCL2 apoptosis regulator	Homo sapiens	138-143