PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31207963-9	2019	Moreover, fisetin treatment inhibited LPS-induced activation of the inflammatory Toll-like Receptors (TLR4)/cluster of differentiation 14 (CD14)/phospho-nuclear factor kappa (NF-kappaB) signaling and attenuated other inflammatory mediators (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL1-beta), and cyclooxygenase (COX-2).	fisetin	10-17	cytochrome c oxidase II, mitochondrial	Mus musculus	333-338	
18279803-7	2008	Fisetin also inhibited the gene expression of TNF-alpha, interleukin (IL)-1 beta, cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) at both mRNA and protein levels.	fisetin	0-7	cytochrome c oxidase II, mitochondrial	Mus musculus	98-103	
25169110-5	2015	Fisetin treatment also reduced inflammatory mediators such as COX-2, PGE2 as well as its receptors (EP1-EP4) and MPO activity.	fisetin	0-7	cytochrome c oxidase II, mitochondrial	Mus musculus	62-67	
26878795-5	2016	Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues.	fisetin	10-17	cytochrome c oxidase II, mitochondrial	Mus musculus	230-235	
28213268-10	2017	We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5.	fisetin	14-21	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95	
23688860-4	2013	Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine.	fisetin	29-36	cytochrome c oxidase II, mitochondrial	Mus musculus	191-213