PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19725538-2 2009 Fisetin exhibited an inhibitory effect on the abilities of adhesion, migration, and invasion via inhibiting the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and downregulating the expressions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) at both the protein and mRNA levels in A549 cells. fisetin 0-7 matrix metallopeptidase 2 Homo sapiens 224-250 19725538-2 2009 Fisetin exhibited an inhibitory effect on the abilities of adhesion, migration, and invasion via inhibiting the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and downregulating the expressions of matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (u-PA) at both the protein and mRNA levels in A549 cells. fisetin 0-7 matrix metallopeptidase 2 Homo sapiens 252-257 31028200-5 2019 The gelatin zymography assay showed that fisetin inhibited MMP-2 activity in U-2 OS cells. fisetin 41-48 matrix metallopeptidase 2 Homo sapiens 59-64 31434498-6 2019 The beneficial effect of fisetin was likely attributable to reduced levels of MMP-2, MMP-9, and CRP in the serum, as evidenced by strong linear correlations between serum levels of such markers with the NIHSS scores in all enrolled patients. fisetin 25-32 matrix metallopeptidase 2 Homo sapiens 78-83 19633975-3 2010 Gelatin zymography assay showed that fisetin inhibited the matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities. fisetin 37-44 matrix metallopeptidase 2 Homo sapiens 59-85 19633975-3 2010 Gelatin zymography assay showed that fisetin inhibited the matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities. fisetin 37-44 matrix metallopeptidase 2 Homo sapiens 87-92 19633975-8 2010 These results showed fisetin could inhibit the metastatic ability of PC-3 by reducing MMP-2 and MMP-9 expressions through suppressing phosphoinositide 3-kinase/Akt (PI3K/Akt) and JNK signaling pathways. fisetin 21-28 matrix metallopeptidase 2 Homo sapiens 86-91 34864006-8 2022 A specific COX-2 inhibitor NS-398 as well as fisetin treatment reversed the expression of EMT biomarkers, reduced the activity of MMP-2/9, and blocked the migration and invasion potential induced by CSE. fisetin 45-52 matrix metallopeptidase 2 Homo sapiens 130-137