PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11814462-0	2002	Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine.	Quinidine	87-96	orosomucoid 1	Homo sapiens	17-21	
11814462-9	2002	Unbound quinidine concentration in ORM1 F1 phenotype subjects was higher than that in ORM1 S and ORM1 F1S phenotype; the free drug percentage for the subjects with ORM1 F1 phenotype (19.79%) was twice as high as that with ORM1 S phenotype (10.96%) (P<0.01) at 24 h after administration of oral quinidine when the state of disposition equilibrium occurred.	Quinidine	8-17	orosomucoid 1	Homo sapiens	35-39	
11814462-11	2002	CONCLUSIONS: Different ORM1 phenotypes may affect the disposition of quinidine, a basic drug, rather than its hepatic metabolism and elimination.	Quinidine	69-78	orosomucoid 1	Homo sapiens	23-27	
11814462-12	2002	The functional heterogeneity of ORM1 could be responsible for the differences in plasma binding of quinidine.	Quinidine	99-108	orosomucoid 1	Homo sapiens	32-36	
11814462-13	2002	Therefore, monitoring of the unbound quinidine concentration would be important for the patients with different ORM1 phenotypes who are treated with quinidine.	Quinidine	37-46	orosomucoid 1	Homo sapiens	112-116	
11814462-13	2002	Therefore, monitoring of the unbound quinidine concentration would be important for the patients with different ORM1 phenotypes who are treated with quinidine.	Quinidine	149-158	orosomucoid 1	Homo sapiens	112-116	
9620113-8	1998	Quinidine unbound fraction (UF) was related to ORM phenotype.	Quinidine	0-9	orosomucoid 1	Homo sapiens	47-50	
9620113-12	1998	Quinidine binding showed significant relationships to specific ORM variants.	Quinidine	0-9	orosomucoid 1	Homo sapiens	63-66