PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3085830-2 1986 In volunteers given a fixed dose of 500 mg base and patients with malaria given a quinidine loading dose (15 mg base/kg) mean (SEM) plasma insulin concentrations rose from 6.1 (1.5) mU/l to 10.9 (4.4) mU/l (p less than 0.02) and 10.4 (2.0) mU/l to 18.5 (5.3) mU/l (p less than 0.04), respectively. Quinidine 82-91 insulin Homo sapiens 139-146 3330586-2 1987 From these findings and a review of 10 case reports, we propose that disopyramide causes hypoglycaemia by stimulation of insulin release as described for the antimalarial drugs quinine and quinidine. Quinidine 189-198 insulin Homo sapiens 121-128