PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28347660-4	2017	Quinidine exhibited stronger inhibition than quinine; however, these two compounds inhibited the CYP2D6.10-mediated reaction more weakly than the CYP2D6.1 and CYP2D6.2 reactions.	Quinidine	0-9	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	97-103	
28347660-4	2017	Quinidine exhibited stronger inhibition than quinine; however, these two compounds inhibited the CYP2D6.10-mediated reaction more weakly than the CYP2D6.1 and CYP2D6.2 reactions.	Quinidine	0-9	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	146-152	
28347660-4	2017	Quinidine exhibited stronger inhibition than quinine; however, these two compounds inhibited the CYP2D6.10-mediated reaction more weakly than the CYP2D6.1 and CYP2D6.2 reactions.	Quinidine	0-9	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	146-152	
26657265-8	2016	CYP3A4 and CYP2D6 inhibitory effect of SC and ursolic acid (IC50: 197.49+-2.68, 211.45+-3.54 and IC50: 229.25+-2.52, 212.66+-1.26 microg/mL) was less as compared to that known inhibitors, ketoconazole and quinidine respectively.	Quinidine	205-214	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	11-17	
25681130-10	2015	Preincubation of HLMs and rCYP2D6 resulted in the inactivation of the enzyme, which was attenuated by GFA or quinidine.	Quinidine	109-118	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	26-33	
26600643-7	2015	Fluorescence study revealed that the extract and the biomarker had some inhibition on CYP450 isozymes e.g. CYP3A4 and CYP2D6 (IC50 values of the extract: 102.65 +- 2.63-142.23 +- 2.61 microg/ml and TG: 168.73 +- 4.03-180.90 +- 2.49 microg/ml) which was very less compared to positive controls ketoconazole and quinidine.	Quinidine	310-319	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	118-124	
16307862-6	2006	The results from enzyme kinetic studies were confirmed by incubation of BVT.2938 in the presence of the chemical inhibitor of CYP2D6*1, quinidine.	Quinidine	136-145	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	126-132	
9698290-9	1998	Quinidine, a CYP2D6-specific inhibitor, inhibited ibogaine O-demethylase (IC50 = 0.2 microM), whereas other P450 isoform-specific inhibitors did not inhibit this activity.	Quinidine	0-9	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	13-19	
12502361-6	2003	MD studies on the binding mode of sparteine, quinidine, and quinine in CYP2D2 and CYP2D6 furthermore concurred well with experimentally determined IC(50) values and metabolic profiles.	Quinidine	45-54	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	82-88	
14563706-4	2004	In rat brain microsomes, these activities were not inhibited by anti-P450c21 antibodies, but they were effectively inhibited by the CYP2D-specific chemical inhibitor quinidine and by anti-CYP2D4 antibodies.	Quinidine	166-175	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	188-194	
1632813-7	1992	Propranolol and quinidine, specific inhibitors of debrisoquine 4-hydroxylase, markedly inhibited lidocaine 3-hydroxylase activity of Wistar male rats, but not N-deethylase activity.	Quinidine	16-25	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	50-76	
1763518-0	1991	Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.	Quinidine	40-49	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	125-151