PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10497139-12	1999	Quinidine (a specific CYP2D inhibitor) prevented celecoxib metabolism in dog hepatic microsomes, providing evidence of a predominant role for the CYP2D subfamily in canine celecoxib metabolism.	Quinidine	0-9	cytochrome P450 2D15	Canis lupus familiaris	22-27	
10497139-12	1999	Quinidine (a specific CYP2D inhibitor) prevented celecoxib metabolism in dog hepatic microsomes, providing evidence of a predominant role for the CYP2D subfamily in canine celecoxib metabolism.	Quinidine	0-9	cytochrome P450 2D15	Canis lupus familiaris	146-151	
9721180-9	1998	The human CYP2D6-specific inhibitor quinidine and the rat CYP2D1-specific inhibitor quinine were both shown to be inhibitors of bufuralol 1"-hydroxylase activity for dog liver microsomes, CYP2D15 WT2, and the CYP2D15 V1 variant with nearly equal potency.	Quinidine	36-45	cytochrome P450 2D15	Canis lupus familiaris	209-216	
9721180-9	1998	The human CYP2D6-specific inhibitor quinidine and the rat CYP2D1-specific inhibitor quinine were both shown to be inhibitors of bufuralol 1"-hydroxylase activity for dog liver microsomes, CYP2D15 WT2, and the CYP2D15 V1 variant with nearly equal potency.	Quinidine	36-45	cytochrome P450 2D15	Canis lupus familiaris	188-195	
9721180-10	1998	Thus, the dog expresses a CYP2D ortholog possessing enzymatic activities similar to human CYP2D6, but is affected by the inhibitors quinine and quinidine in a manner closer to that of rat CYP2D1.	Quinidine	144-153	cytochrome P450 2D15	Canis lupus familiaris	26-31	
30113702-8	2018	(+)-M5 formation from (+)-M1 in DLMs was potently inhibited by quinidine (CYP2D inhibitor) but had only a minor impact from all CYP inducers tested.	Quinidine	63-72	cytochrome P450 2D15	Canis lupus familiaris	74-79	
35389533-7	2022	In inhibitor experiments, quinidine and erythromycin inhibited ITZ hydroxylation in CYP2D15 and CYP3A12, respectively, in an isoform-specific manner.	Quinidine	26-35	cytochrome P450 2D15	Canis lupus familiaris	84-91