PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21779762-6 2011 The pro- and anti-arrhythmic agents flecainide and quinidine increased regional VERPs despite respectively decreasing and increasing the corresponding APD(90)s particularly in Scn5a (+/-) RV epicardia. Quinidine 51-60 sodium channel, voltage-gated, type V, alpha Mus musculus 176-181 23836691-8 2013 Quinidine reduced maximum theta" in WT and caused earlier conduction failure in the RV of both Scn5a(+/-) and WT. Quinidine 0-9 sodium channel, voltage-gated, type V, alpha Mus musculus 95-100 23836691-13 2013 Flecainide or quinidine decreased the pacing rates at which this occurred, through reducing basic cycle distance, in the Scn5a(+/-) RV epicardium, directly predictive of its arrhythmic phenotype. Quinidine 14-23 sodium channel, voltage-gated, type V, alpha Mus musculus 121-126 22461438-7 2012 Scn5a(+/-) hearts showed greater frequencies of arrhythmic endpoints with increased incidences of ventricular tachycardia, diminished by quinidine, and earlier onsets of ventricular fibrillation, particularly following flecainide challenge. Quinidine 137-146 sodium channel, voltage-gated, type V, alpha Mus musculus 0-5 20132234-14 2010 It is concluded that both flecainide and quinidine exert anti-arrhythmogenic effects in Scn3b(-/-) hearts, doing so through modifying VERP rather than DeltaAPD, in contrast to their differing effects in Scn5a(+/-) and Scn5a(+/DeltaKPQ) hearts. Quinidine 41-50 sodium channel, voltage-gated, type V, alpha Mus musculus 218-223 20621962-9 2010 Both flecainide and quinidine then prevented both induced and spontaneous atrial arrhythmias in all the arrhythmic WT and Scn5a+/- hearts, in contrast to their differing ventricular effects. Quinidine 20-29 sodium channel, voltage-gated, type V, alpha Mus musculus 122-127 20621962-10 2010 However, flecainide prolonged APD(90) in WT but not Scn5a+/-, whereas quinidine prolonged APD(90) in both WT and Scn5a+/-. Quinidine 70-79 sodium channel, voltage-gated, type V, alpha Mus musculus 113-118 17303635-6 2007 Quinidine (10 microM) prevented VT in six out of six flecainide-treated WT and 13 out of the 16 arrhythmogenic Scn5a+/- hearts in parallel with its clinical effects. Quinidine 0-9 sodium channel, voltage-gated, type V, alpha Mus musculus 111-116