PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34048814-12	2021	Thus, our data provide, for the first time, a detailed biophysical characterization of dysfunctional Na+ channels linked to compound heterozygosity in BrS as well as the benefits of the pharmacological treatment using quinidine on the biophysical properties of Nav1.5.	Quinidine	218-227	sodium voltage-gated channel alpha subunit 5	Homo sapiens	261-267	
33084224-0	2020	A combination of quinidine/mexiletine reduces arrhythmia in dilated cardiomyopathy in two patients with R814W SCN5A mutation.	Quinidine	17-26	sodium voltage-gated channel alpha subunit 5	Homo sapiens	110-115	
33684260-2	2021	Here we present the cryo-EM structure of full-length human Na v 1.5 bound to quinidine, a class Ia antiarrhythmic drug, at 3.3 A resolution.	Quinidine	77-86	sodium voltage-gated channel alpha subunit 5	Homo sapiens	59-67	
33712541-5	2021	The structure is nearly identical to that of the wild-type human Nav1.5 bound to quinidine.	Quinidine	81-90	sodium voltage-gated channel alpha subunit 5	Homo sapiens	65-71	
29871609-0	2018	Rapid and effective response of the R222Q SCN5A to quinidine treatment in a patient with Purkinje-related ventricular arrhythmia and familial dilated cardiomyopathy: a case report.	Quinidine	51-60	sodium voltage-gated channel alpha subunit 5	Homo sapiens	42-47	
29871609-10	2018	The quinidine treatment for the SCN5A R222Q mutation can be life saving for patients.	Quinidine	4-13	sodium voltage-gated channel alpha subunit 5	Homo sapiens	32-37	
34373326-10	2021	We also show that both phosphorylation and patient mutations can impact Nav1.5 sensitivity toward the clinically used antiarrhythmic drugs quinidine and ranolazine, but not flecainide.	Quinidine	139-148	sodium voltage-gated channel alpha subunit 5	Homo sapiens	72-78	
17604185-3	2007	METHODS: The effects of D,L-sotalol, flecainide and quinidine were investigated on potassium (hERG) and sodium (Na(V)1.5) currents transfected in HEK-293 cells to determine the repercussion of the blockade of these currents on rabbit Purkinje fibre (PF) and atrial action potentials.	Quinidine	52-61	sodium voltage-gated channel alpha subunit 5	Homo sapiens	111-120