PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18579519-6 2008 Butylated hydroxyanisol, an antioxidant, and diphenyleneiodonium, an inhibitor of NADPH oxidase, attenuated the phosphorylation and degradation of IkappaBalpha by TNFalpha stimulation. diphenyleneiodonium 45-64 tumor necrosis factor Homo sapiens 163-171 18206249-4 2008 Consistent with previous reports in other cell types, blockade of TNFalpha-induced ROS by treatment with N-acetylcysteine, diphenylene iodonium or NADPH oxidase 4 (NOX4) siRNA suppressed TNFalpha-induced ICAM-1 expression and subsequent monocytic adhesion, indicating that TNFalpha mediates pro-inflammatory signals via NOX4-dependent ROS generation in human endothelial cells. diphenyleneiodonium 123-143 tumor necrosis factor Homo sapiens 66-74 18206249-4 2008 Consistent with previous reports in other cell types, blockade of TNFalpha-induced ROS by treatment with N-acetylcysteine, diphenylene iodonium or NADPH oxidase 4 (NOX4) siRNA suppressed TNFalpha-induced ICAM-1 expression and subsequent monocytic adhesion, indicating that TNFalpha mediates pro-inflammatory signals via NOX4-dependent ROS generation in human endothelial cells. diphenyleneiodonium 123-143 tumor necrosis factor Homo sapiens 187-195 18206249-4 2008 Consistent with previous reports in other cell types, blockade of TNFalpha-induced ROS by treatment with N-acetylcysteine, diphenylene iodonium or NADPH oxidase 4 (NOX4) siRNA suppressed TNFalpha-induced ICAM-1 expression and subsequent monocytic adhesion, indicating that TNFalpha mediates pro-inflammatory signals via NOX4-dependent ROS generation in human endothelial cells. diphenyleneiodonium 123-143 tumor necrosis factor Homo sapiens 187-195 18365690-3 2008 Diphenyleneiodonium and apocynin, both NADPH oxidase inhibitors, also suppressed TNF-alpha-induced ROS and monocyte-endothelial cell adhesion, demonstrating that TNF-alpha-induced monocyte adhesion is mediated through ROS produced by NADPH oxidase activation. diphenyleneiodonium 0-19 tumor necrosis factor Homo sapiens 81-90 18218673-8 2008 Moreover, TNF-alpha-induced cytosolic ROS production was inhibited by Rac1 inhibition, diphenyleneiodonium (DPI, an inhibitor of NADPH oxidase), and NAC. diphenyleneiodonium 87-106 tumor necrosis factor Homo sapiens 10-19 18218673-8 2008 Moreover, TNF-alpha-induced cytosolic ROS production was inhibited by Rac1 inhibition, diphenyleneiodonium (DPI, an inhibitor of NADPH oxidase), and NAC. diphenyleneiodonium 108-111 tumor necrosis factor Homo sapiens 10-19 18218673-9 2008 In addition, DPI inhibited TNF-alpha-induced apoptosis as judged by morphological changes, DNA fragmentation, and JNK1/2 activation. diphenyleneiodonium 13-16 tumor necrosis factor Homo sapiens 27-36 18182160-7 2008 Diphenyleneiodonium, an inhibitor of NADPH oxidase, and N-acetylcysteine, a potent antioxidant, also inhibited TNF-alpha-induced activation of Mst1 and caspase 3, as well as apoptosis. diphenyleneiodonium 0-19 tumor necrosis factor Homo sapiens 111-120 18365690-3 2008 Diphenyleneiodonium and apocynin, both NADPH oxidase inhibitors, also suppressed TNF-alpha-induced ROS and monocyte-endothelial cell adhesion, demonstrating that TNF-alpha-induced monocyte adhesion is mediated through ROS produced by NADPH oxidase activation. diphenyleneiodonium 0-19 tumor necrosis factor Homo sapiens 162-171 17673675-6 2007 Tumor necrosis factor-alpha and interleukin (IL)-1beta stimulation of SMCs resulted in diphenylene iodonium-sensitive ROS production within intracellular vesicles. diphenyleneiodonium 87-107 tumor necrosis factor Homo sapiens 0-27 12572857-8 2002 The NADPH oxidase inhibitors apocynin and DPI both decreased significantly the U937 adhesion and the E-selectin overexpression on HUVECs submitted to A/R, TNF-alpha, or A/R + TNF-alpha. diphenyleneiodonium 42-45 tumor necrosis factor Homo sapiens 155-164 16982957-6 2006 DETA-NONOate alone had little effect on TNF-stimulated reactive oxygen species, but it enhanced the TNF response when: (1) heme oxygenase-1 expression was blocked with specific small-interfering RNA; (2) heme oxygenase-1 activity was blocked by zinc-protoporphyrin; or (3) NADPH oxidase activity was blocked by diphenyleneiodonium. diphenyleneiodonium 311-330 tumor necrosis factor Homo sapiens 100-103 15276019-5 2004 TNF-alpha significantly increased intracellular ROS generation, which was completely blocked by PEDF or diphenylene iodonium, an inhibitor of NADPH oxidase. diphenyleneiodonium 104-124 tumor necrosis factor Homo sapiens 0-9 15240725-10 2004 Finally, p38 MAPK activation by TNF was blocked by diphenylene iodonium, an inhibitor of flavoprotein oxidoreductase, and by the free radical scavenger N-acetylcystein. diphenyleneiodonium 51-71 tumor necrosis factor Homo sapiens 32-35 16267103-5 2006 TNF-alpha elevated reactive oxygen species (ROS) in smooth muscle cells of intact arteries, and this increase was prevented by apocynin or diphenyleneiodonium (DPI), both of which are NAD(P)H oxidase blockers, but was unaffected by inhibitors of other ROS-generating enzymes. diphenyleneiodonium 139-158 tumor necrosis factor Homo sapiens 0-9 16267103-5 2006 TNF-alpha elevated reactive oxygen species (ROS) in smooth muscle cells of intact arteries, and this increase was prevented by apocynin or diphenyleneiodonium (DPI), both of which are NAD(P)H oxidase blockers, but was unaffected by inhibitors of other ROS-generating enzymes. diphenyleneiodonium 160-163 tumor necrosis factor Homo sapiens 0-9 12572857-8 2002 The NADPH oxidase inhibitors apocynin and DPI both decreased significantly the U937 adhesion and the E-selectin overexpression on HUVECs submitted to A/R, TNF-alpha, or A/R + TNF-alpha. diphenyleneiodonium 42-45 tumor necrosis factor Homo sapiens 175-184 8871661-8 1996 Inhibition of reduced nicotinamide adenine dinucleotide phosphate oxidase activation with diphenyleneiodonium following hypoxia but before reoxygenation prevented the decreases in IL-1beta types I and II, TNF-alpha (p80), and IL-8R expression that was seen following H/R alone. diphenyleneiodonium 90-109 tumor necrosis factor Homo sapiens 205-214 10556796-5 1999 CD11b/CD18-dependent adhesion and mAb 24 antigen expression triggered by physiological agonists such as TNF-alpha were inhibited by diphenylene iodonium (DPI, an inhibitor of flavoprotein oxidoreductase), by free radical scavengers, by tyrosine kinase inhibitors and by PAO. diphenyleneiodonium 132-152 tumor necrosis factor Homo sapiens 104-113 10556796-5 1999 CD11b/CD18-dependent adhesion and mAb 24 antigen expression triggered by physiological agonists such as TNF-alpha were inhibited by diphenylene iodonium (DPI, an inhibitor of flavoprotein oxidoreductase), by free radical scavengers, by tyrosine kinase inhibitors and by PAO. diphenyleneiodonium 154-157 tumor necrosis factor Homo sapiens 104-113 11440974-5 2001 TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P<0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P<0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P<0.05). diphenyleneiodonium 173-192 tumor necrosis factor Homo sapiens 0-9 11440974-5 2001 TNF-alpha induction of fibronectin synthesis was abrogated by the NOS inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (P<0.05) or the flavonoid-containing enzyme inhibitor diphenyleneiodonium (DPI) (P<0.05) and reproduced with the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) (P<0.05). diphenyleneiodonium 194-197 tumor necrosis factor Homo sapiens 0-9 11440974-9 2001 One of these complexes increased after TNF-alpha treatment, an effect inhibited with L-NMMA or DPI. diphenyleneiodonium 95-98 tumor necrosis factor Homo sapiens 39-48 10900176-6 2000 DPI also inhibited TNF and LPS-induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation. diphenyleneiodonium 0-3 tumor necrosis factor Homo sapiens 19-22 10900176-6 2000 DPI also inhibited TNF and LPS-induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation. diphenyleneiodonium 0-3 tumor necrosis factor Homo sapiens 85-95 30692874-10 2019 In the mock, apoptosis induced by TNF-alpha stimulation was decreased by pretreatment with diphenyleneiodonium (DPI), which is an inhibitor of NADPH oxidase (NOX). diphenyleneiodonium 91-110 tumor necrosis factor Homo sapiens 34-43 30692874-10 2019 In the mock, apoptosis induced by TNF-alpha stimulation was decreased by pretreatment with diphenyleneiodonium (DPI), which is an inhibitor of NADPH oxidase (NOX). diphenyleneiodonium 112-115 tumor necrosis factor Homo sapiens 34-43 27932980-4 2016 These TNF-alpha-mediated responses were abrogated by the inhibitors of NADPH oxidase [apocynin (APO) and diphenyleneiodonium chloride (DPI)], ROS [N-acetyl cysteine, (NAC)], NF-kappaB (Bay11-7082) and transfection with siRNA of ASK1, p47 phox , TRAF2, NIK, IKKalpha, IKKbeta, or p65. diphenyleneiodonium 105-133 tumor necrosis factor Homo sapiens 6-15 27932980-5 2016 TNF-alpha markedly stimulated NADPH oxidase activation and ROS including superoxide and hydrogen peroxide production which were inhibited by pretreatment with a TNFR1 neutralizing antibody, APO, DPI or transfection with siRNA of TRAF2, ASK1, or p47 phox . diphenyleneiodonium 195-198 tumor necrosis factor Homo sapiens 0-9 27932980-4 2016 These TNF-alpha-mediated responses were abrogated by the inhibitors of NADPH oxidase [apocynin (APO) and diphenyleneiodonium chloride (DPI)], ROS [N-acetyl cysteine, (NAC)], NF-kappaB (Bay11-7082) and transfection with siRNA of ASK1, p47 phox , TRAF2, NIK, IKKalpha, IKKbeta, or p65. diphenyleneiodonium 135-138 tumor necrosis factor Homo sapiens 6-15 27932980-8 2016 We found that pretreatment with NAC, DPI, or APO also attenuated the TNF-alpha-stimulated IKKalpha/beta and NF-kappaB p65 phosphorylation, NF-kappaB (p65) translocation, and NF-kappaB promoter activity in HPAEpiCs. diphenyleneiodonium 37-40 tumor necrosis factor Homo sapiens 69-78 21767632-3 2011 The TNF-alpha-induced expression of VCAM-1 was significantly reduced by respectively 38+-7 or 34+-16% when HUVECs were pretreated with 10 or 30muM viscolin, as shown by Western blotting, and was also significantly reduced by pretreatment with the antioxidants N-acetylcysteine, diphenylene iodonium chloride, and apocynin. diphenyleneiodonium 278-307 tumor necrosis factor Homo sapiens 4-13 25059721-10 2014 Phosphorylation of IKK-alpha/beta and p65, degradation of IkappaBalpha, binding of NF-kappaB to its binding motif, and upregulation of IL-1beta and VCAM-1 induced by TNF-alpha were significantly attenuated by treatment with DPI and apocynin. diphenyleneiodonium 224-227 tumor necrosis factor Homo sapiens 166-175 24907586-7 2014 Suppression of NADPH oxidase by apocynin or diphenyleneiodonium prevented TNF-alpha-evoked morphological changes and apoptosis, attenuated endothelial MMP activity and helped retain usual tight junction protein expression and barrier function. diphenyleneiodonium 44-63 tumor necrosis factor Homo sapiens 74-83 21520062-5 2011 TNF-alpha-induced NF-kappaB translocation was blocked by pretreatment with NAC, DPI, APO, or HLN, but not by U0126, SB202190, or SP600125. diphenyleneiodonium 80-83 tumor necrosis factor Homo sapiens 0-9