PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34478504-7	2021	Inhibition of NOX2 with diphenyleneiodonium chloride or GSK2795039 abrogated HIT-induced thrombi in vivo using FcgammaRIIa+/hPF4+ transgenic mice.	diphenyleneiodonium	24-52	cytochrome b-245, beta polypeptide	Mus musculus	14-18	
31923552-11	2020	More importantly, post-treatment with NOX2 inhibitor diphenyleneiodonium when NE-LC neurodegeneration had already begun, still showed high efficacy in protecting NE-LC neurons from degeneration in LPS-treated mice.	diphenyleneiodonium	53-72	cytochrome b-245, beta polypeptide	Mus musculus	38-42	
28804558-0	2017	NADPH oxidase 2 inhibitor diphenyleneiodonium enhances ROS-independent bacterial phagocytosis in murine macrophages via activation of the calcium-mediated p38 MAPK signaling pathway.	diphenyleneiodonium	26-45	cytochrome b-245, beta polypeptide	Mus musculus	0-15	
28804558-3	2017	Here, we found that the classic NOX2 inhibitor diphenyleneiodonium (DPI) induced uptake of E. coli by murine peritoneal macrophages through enhancing phagocytosis, and this effect was temperature-sensitive and attenuated by cytochalasin D as well as chemical inhibition of Syk and PLCgamma, two downstream kinases involved in actin polymerization during phagocytosis.	diphenyleneiodonium	47-66	cytochrome b-245, beta polypeptide	Mus musculus	32-36	
28804558-3	2017	Here, we found that the classic NOX2 inhibitor diphenyleneiodonium (DPI) induced uptake of E. coli by murine peritoneal macrophages through enhancing phagocytosis, and this effect was temperature-sensitive and attenuated by cytochalasin D as well as chemical inhibition of Syk and PLCgamma, two downstream kinases involved in actin polymerization during phagocytosis.	diphenyleneiodonium	68-71	cytochrome b-245, beta polypeptide	Mus musculus	32-36	
28804558-5	2017	The DPI-induced enhancement of phagocytosis was independent of NOX2 inhibition or ROS generation but depended on increased intracellular calcium and activation of the p38 MAPK signaling pathway.	diphenyleneiodonium	4-7	cytochrome b-245, beta polypeptide	Mus musculus	63-67	
24277523-12	2014	NOX2 inhibitor diphenylene iodonium protects against iron-elicited dopaminergic neurotoxicity through decreasing microglial O2 - generation, and NOX2-/- mice are resistant to the neurotoxicity by reducing microglial O2 - production, indicating that iron-elicited dopaminergic neurotoxicity is dependent of NOX2, a O2 --generating enzyme.	diphenyleneiodonium	15-35	cytochrome b-245, beta polypeptide	Mus musculus	0-4	
19696433-4	2009	ATP-mediated ROS production was strongly attenuated in NOX2-deficient macrophages where responses were comparable to inhibition with diphenyleneiodonium.	diphenyleneiodonium	133-152	cytochrome b-245, beta polypeptide	Mus musculus	55-59	
23027866-7	2012	Addition of the antioxidant diphenylene iodonium (DPI) diminished DMXAA-induced IFN-beta, but this decrease was independent of both the NADPH oxidase, Nox2, and de novo generation of reactive oxygen species.	diphenyleneiodonium	28-48	cytochrome b-245, beta polypeptide	Mus musculus	151-155	
20826812-8	2010	Moreover, chemical antioxidants, such as N-acetylcysteine and butylated hydroxyanisole, and the NADPH oxidase inhibitor diphenyleneiodonium inhibited Srx induction as well as generation of reactive oxygen species, both of which were also suppressed in Nox2 (NADPH oxidase 2)-deficient bone marrow-derived macrophages.	diphenyleneiodonium	120-139	cytochrome b-245, beta polypeptide	Mus musculus	252-256	
20826812-8	2010	Moreover, chemical antioxidants, such as N-acetylcysteine and butylated hydroxyanisole, and the NADPH oxidase inhibitor diphenyleneiodonium inhibited Srx induction as well as generation of reactive oxygen species, both of which were also suppressed in Nox2 (NADPH oxidase 2)-deficient bone marrow-derived macrophages.	diphenyleneiodonium	120-139	cytochrome b-245, beta polypeptide	Mus musculus	258-273