PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17085541-4	2007	Antioxidants DPI or apocynin completely blocked insulin-stimulated HIF-1 activation.	diphenyleneiodonium	13-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	67-72	
17085541-8	2007	First, tyrosine phosphatase-specific inhibitor sodium vanadate compensates DPI-inhibited HIF-1 activity.	diphenyleneiodonium	75-78	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-94	
17085541-5	2007	The restoration of HIF-1 activation by H(2)O(2) in DPI-pretreated cells not only confirmed the role of ROS but also identified H(2)O(2) as the responsible ROS.	diphenyleneiodonium	51-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-24	
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --> ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	diphenyleneiodonium	107-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	265-276	
15110393-7	2004	Interference with ROS metabolism by the flavoprotein inhibitor diphenylene iodonium (DPI) and catalase inhibited HIF-1 induction.	diphenyleneiodonium	63-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-118	
15110393-7	2004	Interference with ROS metabolism by the flavoprotein inhibitor diphenylene iodonium (DPI) and catalase inhibited HIF-1 induction.	diphenyleneiodonium	85-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	113-118	
12101082-7	2002	Inhibition of the mitochondrion complex I nicotinamide adenine dinucleotide phosphate-dependent oxidase by diphenylene iodonium (DPI), which blocks the conversion of ubiquinone --> ubiquinol, abrogated IL-1 beta-dependent nuclear translocation and activation of HIF-1 alpha.	diphenyleneiodonium	129-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	265-276	
21620448-5	2011	METHODS: Diphenyleneiodonium (DPI), an irreversible ROS inhibitor, was used to inhibit the generation of ROS in EOC cell lines, SKOV-3 and MDAH-2774, followed by assessment of apoptosis, NADPH oxidase, SOD3 and HIF-1alpha expression.	diphenyleneiodonium	9-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	211-221	
24732598-9	2014	However, treatment with a NADPH oxidase inhibitor, diphenyleneiodonium (DPI), strongly inhibited ROS generation and HIF-1alpha expression, as well as cell migration and invasion.	diphenyleneiodonium	51-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126	
21252047-10	2011	Both N-acetyl cysteine and diphenylene iodonium, a NADP(H) inhibitor, inhibited the expression of HIF-1alpha and VEGF stimulated by leptin or PDGF.	diphenyleneiodonium	27-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-108	
10837481-7	2000	The induction of HIF-1alpha by hormones is mediated through the production of reactive oxygen species (ROS), since it can be blocked by the ROS inhibitors, diphenyleneiodonium and catalase.	diphenyleneiodonium	156-175	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27	
24732598-9	2014	However, treatment with a NADPH oxidase inhibitor, diphenyleneiodonium (DPI), strongly inhibited ROS generation and HIF-1alpha expression, as well as cell migration and invasion.	diphenyleneiodonium	72-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126	
21620448-5	2011	METHODS: Diphenyleneiodonium (DPI), an irreversible ROS inhibitor, was used to inhibit the generation of ROS in EOC cell lines, SKOV-3 and MDAH-2774, followed by assessment of apoptosis, NADPH oxidase, SOD3 and HIF-1alpha expression.	diphenyleneiodonium	30-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	211-221	
21620448-8	2011	Additionally, both EOC cell lines were found to express NADPH oxidase, HIF-1alpha, and SOD3, which were highly sensitive to DPI treatment.	diphenyleneiodonium	124-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81	
21620448-9	2011	DPI treatment resulted in reduced NADPH oxidase, SOD3 and HIF-1alpha levels.	diphenyleneiodonium	0-3	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-68	
18199003-7	2008	LPS-induced HIF-1 activation was blocked by treatment with antioxidant (N-acetylcysteine or thioredoxin-1), NADPH oxidase inhibitor (diphenyleneiodonium), indicating that reactive oxygen species generated in response to LPS are essential in this process.	diphenyleneiodonium	133-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	12-17