PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26760964-5	2016	Treatment of cells with diphenyleneiodonium chloride, an inhibitor of Nox1, significantly decreased the migration ability of Hs294t and SK-Mel28 cells.	diphenyleneiodonium	24-52	NADPH oxidase 1	Homo sapiens	70-74	
27743884-3	2017	Different strategies involving Nox1 inhibition based on diphenylene iodonium derivatives are currently tested for colorectal cancer therapy.	diphenyleneiodonium	56-76	NADPH oxidase 1	Homo sapiens	31-35	
26216939-6	2015	Furthermore, NADPH oxidase 1 inhibition with diphenyleneiodonium chloride protects neutrophils against fingolimod-mediated cell death.	diphenyleneiodonium	45-73	NADPH oxidase 1	Homo sapiens	13-28	
23314043-6	2013	Not only did DPI and DTI decrease intracellular ROS, they both also significantly decreased the mRNA expression levels of Nox1, potentially contributing to the prolonged reduction in tumor cell reactive oxygen levels.	diphenyleneiodonium	13-16	NADPH oxidase 1	Homo sapiens	122-126	
22305747-2	2012	The flavoenzyme inhibitors diphenylene iodonium (DPI) and di-2-thienyliodonium (DTI) have been used to inhibit membrane-bound, flavoprotein-containing NADPH oxidases, including epithelial and leukocyte NADPH oxidases (Nox1-5 and Duox 1 and 2).	diphenyleneiodonium	27-47	NADPH oxidase 1	Homo sapiens	218-224	
22305747-2	2012	The flavoenzyme inhibitors diphenylene iodonium (DPI) and di-2-thienyliodonium (DTI) have been used to inhibit membrane-bound, flavoprotein-containing NADPH oxidases, including epithelial and leukocyte NADPH oxidases (Nox1-5 and Duox 1 and 2).	diphenyleneiodonium	49-52	NADPH oxidase 1	Homo sapiens	218-224	
22305747-7	2012	Growth inhibition profiling of DPI revealed a modest positive correlation with Nox1 levels; novel mechanisms of DPI and DTI action, including alterations in Stat, Erk1/2, and Akt pathways, were inferred by correlation with NCI-60 Affymetrix( ) array data.	diphenyleneiodonium	31-34	NADPH oxidase 1	Homo sapiens	79-83	
22305747-8	2012	Exposure of HT-29 colon cancer cells, which express Nox1, to DPI and DTI confirmed their inhibitory effects on steady state ROS levels, and demonstrated decreased Stat, Erk1/2, and Akt signaling mediated by IL-4, IL-6, IL-13, and IL-22, possibly due to a concomitant increase in tumor cell phosphatase activity.	diphenyleneiodonium	61-64	NADPH oxidase 1	Homo sapiens	52-56