PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17958324-7	2007	We observed the dose-dependent inhibitory effect of diphenyleneiodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on the ET-1-enhanced ERK1/2 phosphorylation in ESMC.	diphenyleneiodonium	52-71	endothelin 1	Homo sapiens	170-174	
17958324-7	2007	We observed the dose-dependent inhibitory effect of diphenyleneiodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on the ET-1-enhanced ERK1/2 phosphorylation in ESMC.	diphenyleneiodonium	73-76	endothelin 1	Homo sapiens	170-174	
17958324-9	2007	In addition, DPI significantly inhibited the ET-1- induced ROS production when ROS was measured as a function of DCF fluorescence.	diphenyleneiodonium	13-16	endothelin 1	Homo sapiens	45-49	
10826501-9	2000	ET-1-stimulated IL-6 secretion was also suppressed by diphenylene iodonium (40 microM), an inhibitor of flavon-containing enzymes such as NADH/NADPH oxidase.	diphenyleneiodonium	54-74	endothelin 1	Homo sapiens	0-4	
16722034-11	2006	BQ-788, TEMPOL, and DPI inhibited mRNA expression of FN induced by ET-1.	diphenyleneiodonium	20-23	endothelin 1	Homo sapiens	67-71	
15130882-7	2004	Furthermore, the presence of E2 and antioxidants such as N-acetylcysteine and diphenylene iodonium were able to elicit a decrease in the level of strain-induced ET-1 secretion, ET-1 promoter activity, ET-1 mRNA, ERK phosphorylation, and activator protein-1 binding activity.	diphenyleneiodonium	78-98	endothelin 1	Homo sapiens	161-165	
15130882-7	2004	Furthermore, the presence of E2 and antioxidants such as N-acetylcysteine and diphenylene iodonium were able to elicit a decrease in the level of strain-induced ET-1 secretion, ET-1 promoter activity, ET-1 mRNA, ERK phosphorylation, and activator protein-1 binding activity.	diphenyleneiodonium	78-98	endothelin 1	Homo sapiens	177-181	
15130882-7	2004	Furthermore, the presence of E2 and antioxidants such as N-acetylcysteine and diphenylene iodonium were able to elicit a decrease in the level of strain-induced ET-1 secretion, ET-1 promoter activity, ET-1 mRNA, ERK phosphorylation, and activator protein-1 binding activity.	diphenyleneiodonium	78-98	endothelin 1	Homo sapiens	177-181	
12417265-4	2002	All of the antioxidants examined, i.e. N-acetyl-L-cysteine (NAC), diphenyleneiodonium chloride (DPI), and L-(+)-ascorbic acid (ascorbic acid), inhibited both ET-1 (1-31)- and ET-1-induced JNK and p38 MAPK activation but not ERK1/2 activation.	diphenyleneiodonium	66-94	endothelin 1	Homo sapiens	158-162	
12417265-4	2002	All of the antioxidants examined, i.e. N-acetyl-L-cysteine (NAC), diphenyleneiodonium chloride (DPI), and L-(+)-ascorbic acid (ascorbic acid), inhibited both ET-1 (1-31)- and ET-1-induced JNK and p38 MAPK activation but not ERK1/2 activation.	diphenyleneiodonium	66-94	endothelin 1	Homo sapiens	175-179	
12417265-7	2002	ET-1 (1-31)- and ET-1-induced cellular ROS generation was inhibited similarly by NAC, DPI, and ascorbic acid in RASMC.	diphenyleneiodonium	86-89	endothelin 1	Homo sapiens	0-4	
15203192-6	2004	Pretreatment of A-10 VSMCs with diphenyleneiodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, attenuated ET-1-enhanced ERK1/2, PKB, and Pyk2 phosphorylation.	diphenyleneiodonium	32-51	endothelin 1	Homo sapiens	147-151	
15203192-6	2004	Pretreatment of A-10 VSMCs with diphenyleneiodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, attenuated ET-1-enhanced ERK1/2, PKB, and Pyk2 phosphorylation.	diphenyleneiodonium	53-56	endothelin 1	Homo sapiens	147-151	
15203192-7	2004	In addition, in parallel with an inhibitory effect on the above signaling components, DPI also blocked ET-1-induced protein synthesis.	diphenyleneiodonium	86-89	endothelin 1	Homo sapiens	103-107	
15203192-8	2004	ET-1 was also found to increase ROS production, which was suppressed by DPI treatment.	diphenyleneiodonium	72-75	endothelin 1	Homo sapiens	0-4	
12417265-7	2002	ET-1 (1-31)- and ET-1-induced cellular ROS generation was inhibited similarly by NAC, DPI, and ascorbic acid in RASMC.	diphenyleneiodonium	86-89	endothelin 1	Homo sapiens	17-21	
12417265-10	2002	This ET-1 (1-31)-induced increase in [3H]thymidine incorporation was also inhibited by NAC and DPI, but not by ascorbic acid.	diphenyleneiodonium	95-98	endothelin 1	Homo sapiens	5-9	
11597896-6	2001	Wortmannin, LY-294002, diphenyleneiodonium (DPI), 4-(2-aminoethyl)benzenesulfonyl fluoride, and apocynin also prevented the ET-1-mediated increases in superoxide production and viable cell numbers.	diphenyleneiodonium	23-42	endothelin 1	Homo sapiens	124-128	
11597896-6	2001	Wortmannin, LY-294002, diphenyleneiodonium (DPI), 4-(2-aminoethyl)benzenesulfonyl fluoride, and apocynin also prevented the ET-1-mediated increases in superoxide production and viable cell numbers.	diphenyleneiodonium	44-47	endothelin 1	Homo sapiens	124-128