PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34740688-4 2021 Hence, the present study aims to examine the effect of multifunctional fused tricyclic 7-hydroxy 4-methy coumarin analogs (HMC1-5) on the self-induced aggregation of beta-amyloid using Thioflavin T (ThT) assay, scanning electron microscopic study, AlamarBlue and immune blotting assays and also the binding mechanism with AChE by fluorescence emission, conformational, molecular docking and molecular dynamic simulation studies under physiological pH 7.4. 7-hydroxy 4-methy coumarin 87-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 322-326