PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31919406-10	2020	DCA could upregulate CAB39 expression, which activates the AMPK/mTOR signalling pathway.	Dichloroacetic Acid	0-3	mechanistic target of rapamycin kinase	Homo sapiens	64-68	
31762813-0	2019	Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR-543/PTEN/Akt/mTOR Pathway.	Dichloroacetic Acid	0-15	mechanistic target of rapamycin kinase	Homo sapiens	104-108	
31762813-12	2019	In conclusion, DCA restored chemosensitivity through miR-543/PTEN/Akt/mTOR pathway, and miR-543 may be a potential marker or therapeutic target for chemoresistance in CRC.	Dichloroacetic Acid	15-18	mechanistic target of rapamycin kinase	Homo sapiens	70-74	
30513596-8	2018	Here, we show that glucose deprivation synergizes with propranolol for anti-cancer activity, and that the rational combination of propranolol and dichloroacetate (DCA), a clinically available glycolytic inhibitor, dramatically attenuates tumor cell metabolism and mTOR signaling, inhibits proliferation and colony formation, and induces apoptosis.	Dichloroacetic Acid	146-161	mechanistic target of rapamycin kinase	Homo sapiens	264-268	
30513596-8	2018	Here, we show that glucose deprivation synergizes with propranolol for anti-cancer activity, and that the rational combination of propranolol and dichloroacetate (DCA), a clinically available glycolytic inhibitor, dramatically attenuates tumor cell metabolism and mTOR signaling, inhibits proliferation and colony formation, and induces apoptosis.	Dichloroacetic Acid	163-166	mechanistic target of rapamycin kinase	Homo sapiens	264-268	
29844702-10	2018	The results indicate that the AKT-mTOR pathway, a main negative regulator of autophagy, is involved in the DCA-induced inhibition of autophagy.	Dichloroacetic Acid	107-110	mechanistic target of rapamycin kinase	Homo sapiens	34-38	
28928817-8	2017	Notably, the protein kinase B (Akt)-mechanistic target of rapamycin (mTOR) signaling pathway, an important negative regulator of autophagy, was demonstrated to be suppressed by DCA treatment.	Dichloroacetic Acid	177-180	mechanistic target of rapamycin kinase	Homo sapiens	69-73	
25995437-8	2015	Pretreatment of SQ20B cells with dichloroacetate (DCA), which inhibits PDH-E1alpha phosphorylation by inhibiting dehydrogenase kinases (PDK), reversed the decrease in OCR in response to PI3K/Akt/mTOR inhibition.	Dichloroacetic Acid	33-48	mechanistic target of rapamycin kinase	Homo sapiens	195-199	
25995437-8	2015	Pretreatment of SQ20B cells with dichloroacetate (DCA), which inhibits PDH-E1alpha phosphorylation by inhibiting dehydrogenase kinases (PDK), reversed the decrease in OCR in response to PI3K/Akt/mTOR inhibition.	Dichloroacetic Acid	50-53	mechanistic target of rapamycin kinase	Homo sapiens	195-199	
25976231-5	2015	Melanoma cell lines treated with DCA showed a shift in metabolism, that is, a decrease in glucose consumption and lactate production, downregulation of proliferation, an increase of apoptosis and a decrease in mTOR pathway activation.	Dichloroacetic Acid	33-36	mechanistic target of rapamycin kinase	Homo sapiens	210-214	
24892448-8	2014	CONCLUSIONS: DCA induces autophagy in cancer cells accompanied by ROS production and mTOR inhibition, reduced lactate excretion, reduced k(PL) and increased NAD(+)/NADH ratio.	Dichloroacetic Acid	13-16	mechanistic target of rapamycin kinase	Homo sapiens	85-89	
24201812-0	2013	Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling.	Dichloroacetic Acid	0-15	mechanistic target of rapamycin kinase	Homo sapiens	122-126	
24201812-8	2013	Finally, we demonstrated that the Akt-mTOR signaling pathway, a major negative regulator of autophagy, was suppressed by DCA treatment.	Dichloroacetic Acid	121-124	mechanistic target of rapamycin kinase	Homo sapiens	38-42	
24201812-9	2013	To our knowledge, it was the first study to show that DCA induced protective autophagy in LoVo cells, and the potential mechanisms were involved in ROS imbalance and Akt-mTOR signaling pathway suppression.	Dichloroacetic Acid	54-57	mechanistic target of rapamycin kinase	Homo sapiens	170-174	
11259315-4	2001	In intact cells the NADH ED-FRAP was sensitive to temperature (Q(10) of 2.5) and to dehydrogenase activation by dichloroacetate or cAMP (twofold increase for each).	Dichloroacetic Acid	112-127	mechanistic target of rapamycin kinase	Homo sapiens	28-32	
34678088-8	2022	PI3K pathway inhibitor LY294002 or MEK pathway inhibitor U0126, or Warburg effect inhibitor DCA was used to carry out western blot and glucose metabolism experiments, and the results showed that PDGFBB/PDGFRbeta mainly activated the PI3K/AKT/mTOR/ c-Myc pathway to promote aerobic glycolysis in osteosarcoma HOS cells.	Dichloroacetic Acid	92-95	mechanistic target of rapamycin kinase	Homo sapiens	242-246	
34576192-11	2021	Metformin and DCA inhibited mTOR complex I signaling through upregulated AMPK-independent REDD1.	Dichloroacetic Acid	14-17	mechanistic target of rapamycin kinase	Homo sapiens	28-32