PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27597806-6 2016 Similarly, pharmacological inhibition of catalase activity using 3-aminotriazole induced the same phenotypic switch and inflammatory response in RAW264.7 macrophages. Amitrole 65-80 catalase Mus musculus 41-49 28826225-6 2018 This was followed by an increased proliferative phenotype via the AKT-dependent pathway that was perturbed in the presence of catalase-inhibitor, 3-aminotriazole due to an increased ROS-mediated inactivation of AKT. Amitrole 146-161 catalase Mus musculus 126-134 25884831-1 2015 Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. Amitrole 0-13 catalase Mus musculus 42-50 25884831-1 2015 Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. Amitrole 0-13 catalase Mus musculus 52-55 25884831-1 2015 Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. Amitrole 15-18 catalase Mus musculus 42-50 25884831-1 2015 Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. Amitrole 15-18 catalase Mus musculus 52-55 25884831-6 2015 In mice exposed to APAP, ATZ pretreatment decreased the CAT activities, hydrogen peroxide (H2O2) levels, malondialdehyde (MDA) contents, myeloperoxidase (MPO) levels in liver and reduced TNF-alpha levels in plasma. Amitrole 25-28 catalase Mus musculus 56-59 22687551-5 2012 ATZ dose-dependently inhibited the activity of CAT, but it reduced the content of H(2)O(2) and the levels of malondialdehyde (MDA) in liver tissues. Amitrole 0-3 catalase Mus musculus 47-50 24103023-9 2015 This effect requires ethanol oxidation into acetaldehyde given that, when H2 O2 -catalase system was impaired by either 3-amino-1,2,4-triazole or in vivo administration of alpha-lipoic acid, ethanol did not enhance DA cell activity. Amitrole 120-142 catalase Mus musculus 81-89 23941578-3 2014 Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor. Amitrole 51-64 catalase Mus musculus 93-96 23941578-3 2014 Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor. Amitrole 66-69 catalase Mus musculus 93-96 23941578-8 2014 ATZ inhibited the activity of CAT, increased the content of H2 O2 and the levels of malondialdehyde (MDA) in liver tissues. Amitrole 0-3 catalase Mus musculus 30-33 23871839-7 2013 The hydrogen peroxide detoxifying enzymes catalase and glutathione-peroxidase (GPx) were inhibited using 3-amino-1,2,4-triazole and mercaptosuccinic acid, respectively. Amitrole 105-127 catalase Mus musculus 42-50 22687551-2 2012 Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor. Amitrole 51-64 catalase Mus musculus 93-96 22687551-2 2012 Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor. Amitrole 66-69 catalase Mus musculus 93-96 21440059-4 2011 Hippocampal slices, C6 cells, and N2a cells showed a decrease in the H2O2 decomposition rate (23-28%) by a pretreatment with the catalase inhibitor aminotriazole. Amitrole 148-161 catalase Mus musculus 129-137 21129156-10 2011 In accordance, treatment of mice with the catalase inhibitor aminotriazole for 6 weeks resulted in significant up-regulation of eNOS and ecSOD in vena cava. Amitrole 61-74 catalase Mus musculus 42-50 19929243-5 2010 In striking contrast, inhibition of catalase by aminotriazole strongly reduced circulating EPCs in sedentary cat(++) and their transgen-negative littermates (cat(n)), while forced or voluntary exercise training of cat(++) mice significantly increased the number of circulating EPCs. Amitrole 48-61 catalase Mus musculus 36-44 20648641-5 2010 This difference persisted when catalase was inhibited by 3-aminotriazole, but was abolished when glutathione was depleted by application of buthionine sulfoximine, suggesting a deficit in the glutathione system. Amitrole 57-72 catalase Mus musculus 31-39 20160672-8 2010 The catalase inhibitor 3-amino-1, 2, 4-triazole partially abolished the protective effect of ISO in ZY-challenged mice. Amitrole 23-47 catalase Mus musculus 4-12 18155096-4 2008 Secondly, the specificity of the catalase inhibitor 3-amino-1,2,4-triazole (AT) was evaluated with morphine- and cocaine-induced CPP. Amitrole 52-74 catalase Mus musculus 33-41 19439176-3 2009 To understand whether catalase and SOD contributing in the intracellular survival, were of bacterial origin or not, 3 amino 1,2,4 triazole (ATZ) and Diethyldithiocarbamic acid (DDC) were used to inhibit specifically macrophage derived catalase and SOD respectively. Amitrole 116-138 catalase Mus musculus 235-243 19393613-7 2009 Tie-2-catalase mice have a strongly reduced steady-state concentration of vascular hydrogen peroxide and show profound hypotension that is not dependent on the bioavailability of endothelial nitric oxide but is completely reversible by treatment with the catalase inhibitor aminotriazole. Amitrole 274-287 catalase Mus musculus 6-14 19393613-7 2009 Tie-2-catalase mice have a strongly reduced steady-state concentration of vascular hydrogen peroxide and show profound hypotension that is not dependent on the bioavailability of endothelial nitric oxide but is completely reversible by treatment with the catalase inhibitor aminotriazole. Amitrole 274-287 catalase Mus musculus 255-263 19129733-4 2009 The catalase inhibitor (3-amino-1,2,4-triazole, 50 mM) augmented the constriction and blocked the lowest SCU concentration relaxation, whereas catalase addition was without effect. Amitrole 24-46 catalase Mus musculus 4-12 19341793-4 2009 Incubation with aminotriazole, a catalase inhibitor, prevented the observed diminished growth rate in hCatTg MAECs. Amitrole 16-29 catalase Mus musculus 33-41 19341793-5 2009 Inhibition of catalase activity with aminotriazole abrogated catalase overexpression-induced antiproliferative action. Amitrole 37-50 catalase Mus musculus 14-22 19341793-5 2009 Inhibition of catalase activity with aminotriazole abrogated catalase overexpression-induced antiproliferative action. Amitrole 37-50 catalase Mus musculus 61-69 18155096-4 2008 Secondly, the specificity of the catalase inhibitor 3-amino-1,2,4-triazole (AT) was evaluated with morphine- and cocaine-induced CPP. Amitrole 76-78 catalase Mus musculus 33-41 8060524-0 1994 Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice. Amitrole 11-33 catalase Mus musculus 43-51 16216962-7 2005 Treatment with the catalase inhibitor aminotriazole increased sBP of cat++ to 117.3+/-4.3 mm Hg (P=0.0345), while having no effect in catn (118.4+/-2.4 mm Hg, n=4, P>0.05). Amitrole 38-51 catalase Mus musculus 19-27 12711621-10 2003 Aminotriazole (50 mM), which inhibits catalase, abolished its effect on control mice. Amitrole 0-13 catalase Mus musculus 38-46 12538343-5 2003 Short-term treatment of 3-amino-1,2,4-triazole (3AT), a specific catalase inhibitor, completely suppressed the Cd-elicited JNK activation, conversely, exogenous addition of catalase increased the intensity and duration of JNK activation in Cd-treated CL3 cells. Amitrole 24-46 catalase Mus musculus 65-73 12538343-5 2003 Short-term treatment of 3-amino-1,2,4-triazole (3AT), a specific catalase inhibitor, completely suppressed the Cd-elicited JNK activation, conversely, exogenous addition of catalase increased the intensity and duration of JNK activation in Cd-treated CL3 cells. Amitrole 24-46 catalase Mus musculus 173-181 12538343-5 2003 Short-term treatment of 3-amino-1,2,4-triazole (3AT), a specific catalase inhibitor, completely suppressed the Cd-elicited JNK activation, conversely, exogenous addition of catalase increased the intensity and duration of JNK activation in Cd-treated CL3 cells. Amitrole 48-51 catalase Mus musculus 65-73 12538343-5 2003 Short-term treatment of 3-amino-1,2,4-triazole (3AT), a specific catalase inhibitor, completely suppressed the Cd-elicited JNK activation, conversely, exogenous addition of catalase increased the intensity and duration of JNK activation in Cd-treated CL3 cells. Amitrole 48-51 catalase Mus musculus 173-181 12439864-3 2002 An irreversible inhibitor, 3-amino-1,2,4-triazole (3-AT), was used to modulate catalase activity. Amitrole 27-49 catalase Mus musculus 79-87 12439864-3 2002 An irreversible inhibitor, 3-amino-1,2,4-triazole (3-AT), was used to modulate catalase activity. Amitrole 51-55 catalase Mus musculus 79-87 12439864-4 2002 Hepatic catalase activity in mice pretreated with CFB (500 mg/kg, i.p., for 10 days) was significantly inhibited by 3-AT (100 or 500 mg/kg, i.p.). Amitrole 116-120 catalase Mus musculus 8-16 11829410-3 2001 Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) and myeloma (SP2/0-Ag-14) cell lines increases Abeta toxicity, suggesting that any protective role for endogenous catalase requires active enzyme. Amitrole 64-67 catalase Mus musculus 202-210 10379628-7 1999 Moreover, an additive effect of cyanamide and another brain catalase inhibitor, 3-amino-1,2,4-triazole (AT), on the reduction of ethanol-induced locomotor activity was observed. Amitrole 80-102 catalase Mus musculus 60-68 10379628-7 1999 Moreover, an additive effect of cyanamide and another brain catalase inhibitor, 3-amino-1,2,4-triazole (AT), on the reduction of ethanol-induced locomotor activity was observed. Amitrole 104-106 catalase Mus musculus 60-68 9167939-7 1997 The sensitivity to catalase inhibitors, such as aminotriazole, azide, or cyanide varies among the isoforms. Amitrole 48-61 catalase Mus musculus 19-27 9013132-3 1997 Sensitivity to 3-amino-1,2,4-triazole (AMT), inhibitor of catalase, was higher in LY-R (hydrogen peroxide sensitive) than in LY-S (hydrogen peroxide resistant) cells. Amitrole 15-37 catalase Mus musculus 58-66 9013132-3 1997 Sensitivity to 3-amino-1,2,4-triazole (AMT), inhibitor of catalase, was higher in LY-R (hydrogen peroxide sensitive) than in LY-S (hydrogen peroxide resistant) cells. Amitrole 39-42 catalase Mus musculus 58-66 17180084-3 1996 Treatment of wild-type WEHI7.2 and bcl-2 transfected cells with a catalase inhibitor, aminotriazole, was not sufficient to induce apoptosis. Amitrole 86-99 catalase Mus musculus 66-74 16585560-4 2006 The cytoprotective effect of NO was abrogated by the catalase inhibitor 3-amino-1,2,4-triazole but was not affected by a glutathione synthesis inhibitor, L-buthionine-(S,R)-sulfoximine. Amitrole 72-94 catalase Mus musculus 53-61 15608607-4 2004 METHODS: Swiss male mice received an intraperitoneal injection of the catalase inhibitor 3-amino-1,2,4-triazole (AT; 0-1 g/kg), and 0 to 20 hr after this administration, animals received an ethanol (0-4 g/kg; intraperitoneally) challenge. Amitrole 89-111 catalase Mus musculus 70-78 15608607-10 2004 These effects of AT and cyanamide on ethanol-induced corticosterone values were observed under treatment conditions that decreased significantly brain catalase activity. Amitrole 17-19 catalase Mus musculus 151-159 12474118-7 2002 The H(2)O(2)-mediated inactivation of endogenous brain catalase activity following an injection of 3-amino-1,2,4-triazole was used as a measure of the rate of cerebral H(2)O(2) production. Amitrole 99-121 catalase Mus musculus 55-63 11156587-12 2001 The relaxations to EFS were significantly inhibited by the oxidants hydrogen peroxide (70 microM) and duroquinone (10 microM) but only after inhibition of catalase with 3-amino-1,2,4-triazole or after inhibition of Cu/ZnSOD with DETCA respectively. Amitrole 169-191 catalase Mus musculus 155-163 8489262-12 1993 The catalase inhibitor aminotriazole decreased ethanol and methanol metabolism 75% in ADH- deer mice. Amitrole 23-36 catalase Mus musculus 4-12 3928682-9 1985 Consistent with this, inhibition of tumor cell glutathione disulfide reductase with 1,3-bis(2-chloroethyl)-1-nitrosourea or inhibition of endogenous catalase with aminotriazole synergistically augmented cytolysis by vernolepin. Amitrole 163-176 catalase Mus musculus 149-157 1962528-7 1991 3-Amino-1,2,4-triazole (AT), a specific catalase inhibitor, significantly increased the formation of metHb. Amitrole 0-22 catalase Mus musculus 40-48 1962528-7 1991 3-Amino-1,2,4-triazole (AT), a specific catalase inhibitor, significantly increased the formation of metHb. Amitrole 24-26 catalase Mus musculus 40-48 2833253-9 1988 Inhibitors of superoxide dismutase (sodium diethyldithiocarbamate) and catalase (hydroxyl amine and 3, amino 1,2,4-triazole) augmented Pf-II-mediated cutaneous photosensitization. Amitrole 100-123 catalase Mus musculus 14-79 8451258-3 1993 Data suggested that the application of 3-amino-1,2,4-triazole (AT), a catalase inhibitor, to both substrains of mice resulted in a proportional decrease in motor activity, thus supporting our earlier observations. Amitrole 39-61 catalase Mus musculus 70-78 8451258-3 1993 Data suggested that the application of 3-amino-1,2,4-triazole (AT), a catalase inhibitor, to both substrains of mice resulted in a proportional decrease in motor activity, thus supporting our earlier observations. Amitrole 63-65 catalase Mus musculus 70-78 34649350-7 2021 Consistently, the effects of GW501516 on ferroptosis of xCT-deficient MEFs were counteracted in the presence of 3-amino-1,2,4-triazole, a specific inhibitor of catalase, suggesting that catalase is essential for the effect of PPARdelta on ferroptosis triggered by xCT deficiency. Amitrole 112-134 catalase Mus musculus 160-168 34649350-7 2021 Consistently, the effects of GW501516 on ferroptosis of xCT-deficient MEFs were counteracted in the presence of 3-amino-1,2,4-triazole, a specific inhibitor of catalase, suggesting that catalase is essential for the effect of PPARdelta on ferroptosis triggered by xCT deficiency. Amitrole 112-134 catalase Mus musculus 186-194 3428124-6 1987 In vivo experiments with aminotriazole, which blocks catalase irreversibly, indicated that doxorubicin stimulates the synthesis of cardiac catalase. Amitrole 25-38 catalase Mus musculus 53-61 3428124-6 1987 In vivo experiments with aminotriazole, which blocks catalase irreversibly, indicated that doxorubicin stimulates the synthesis of cardiac catalase. Amitrole 25-38 catalase Mus musculus 139-147 33496364-7 2021 Consistently, genetic ablation of autophagy, Atg5 led to suppression of pexophagy during catalase inhibition by 3-aminotriazole (3AT). Amitrole 112-127 catalase Mus musculus 89-97 7126616-0 1982 The effects of clofibrate and 3-amino-1,2,4-triazole on liver catalase and lipid metabolism in mice. Amitrole 30-52 catalase Mus musculus 62-70 731180-1 1978 Some pharmacological and toxicological effects of dietary 3-amino-1,2,4-triazole (AT), a known catalase inhibitor, antithyroid agent, and carcinogen, have been examined, using acatalasemic (Csb) and normal catalase, "wild-type" (Csa) substrains of highly inbred C3H and C57BL mice. Amitrole 58-80 catalase Mus musculus 95-103 731180-1 1978 Some pharmacological and toxicological effects of dietary 3-amino-1,2,4-triazole (AT), a known catalase inhibitor, antithyroid agent, and carcinogen, have been examined, using acatalasemic (Csb) and normal catalase, "wild-type" (Csa) substrains of highly inbred C3H and C57BL mice. Amitrole 82-84 catalase Mus musculus 95-103 642030-0 1978 Carcinogenic and antitumor effects of aminotriazole on acatalasemic and normal catalase mice. Amitrole 38-51 catalase Mus musculus 56-64 1154374-0 1975 Recovery of catalase activity after inhibition with aminotriazole in acatalasemia mice. Amitrole 52-65 catalase Mus musculus 12-20 1154374-1 1975 The kinetics of catalase synthesis and degradation were determined in acatalasemia and normal mouse livers during recovery of catalase activity after inhibition with aminotriazole. Amitrole 166-179 catalase Mus musculus 16-24 14149973-0 1963 [REPORT ON THE EFFECTS OF 3-AMINO-1,2,4-TRIAZOLE ON THE ACTIVITY OF HEPATIC CATALASE, AND HEPATIC CELLS IN MICE]. Amitrole 26-48 catalase Mus musculus 76-84 33606716-3 2021 Here, we show that inhibition of catalase by 3-aminotriazole (3-AT) results in the generation of peroxisomal ROS, which contribute to leaky peroxisomes in RAW264.7 cells. Amitrole 45-60 catalase Mus musculus 33-41 33606716-3 2021 Here, we show that inhibition of catalase by 3-aminotriazole (3-AT) results in the generation of peroxisomal ROS, which contribute to leaky peroxisomes in RAW264.7 cells. Amitrole 62-66 catalase Mus musculus 33-41 7126616-2 1982 Repeated administration of aminotriazole to clofibrate-treated mice effectively abolished the elevated catalase activity, but had no significant effect on the reduced plasma triacylglycerol levels. Amitrole 27-40 catalase Mus musculus 103-111 7126616-4 1982 Repeated administration of aminotriazole to control mice resulted in significantly lowered carcass fat and plasma triacylglycerol levels even though the liver catalase activity was greatly depressed. Amitrole 27-40 catalase Mus musculus 159-167 666320-0 1978 On the synthesis and degradation of the multiple forms of catalase in mouse liver: effects of aminotriazole and p-chlorophenoxyisobutric acid ethyl ester. Amitrole 94-107 catalase Mus musculus 58-66 1150002-4 1975 4) In the mice, whose liver catalase activity had been irreversibly inhibited by injection of 3-amino-1,2,4-triazole, the initial rate for the restoration of the liver catalase activity was significantly showed by further injection of sarcoma nuclear fraction. Amitrole 94-116 catalase Mus musculus 28-36 1150002-4 1975 4) In the mice, whose liver catalase activity had been irreversibly inhibited by injection of 3-amino-1,2,4-triazole, the initial rate for the restoration of the liver catalase activity was significantly showed by further injection of sarcoma nuclear fraction. Amitrole 94-116 catalase Mus musculus 168-176 31877356-7 2020 Inhibition of catalase by 3-aminotriazole in hepatocytes resulted in the following effects: (i) increased peroxisomal H2O2 levels as measured by a peroxisome-targeted H2O2 probe (HyPer-P); (ii) elevated intracellular ROS; (iii) decreased peroxisomal biogenesis; (iv) activated ER stress; (v) induced lipogenic genes and neutral lipid accumulation; and (vi) suppressed insulin signaling cascade associated with JNK activation. Amitrole 26-41 catalase Mus musculus 14-22 32351670-2 2020 In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Amitrole 53-75 catalase Mus musculus 99-107 32351670-2 2020 In this study, we aimed to investigate the effect of 3-amino-1,2,4-triazole (ATZ), an inhibitor of catalase and heme synthesis, in a murine model for MetS. Amitrole 77-80 catalase Mus musculus 99-107