PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28653416-8 2017 Previously, a similar compound, 3-amino-1,2,4-triazole (amitrole) was also shown to bind to LPO in the substrate-binding site on the distal heme side. Amitrole 32-54 lactoperoxidase Homo sapiens 92-95 28653416-8 2017 Previously, a similar compound, 3-amino-1,2,4-triazole (amitrole) was also shown to bind to LPO in the substrate-binding site on the distal heme side. Amitrole 56-64 lactoperoxidase Homo sapiens 92-95 2519707-0 1989 Suicide inactivation of lactoperoxidase by 3-amino-1,2,4-triazole. Amitrole 43-65 lactoperoxidase Homo sapiens 24-39 2519707-6 1989 The similarities between lactoperoxidase and thyroid peroxidase suggest a similar mechanism for inhibition of thyroid hormone synthesis by amitrole. Amitrole 139-147 lactoperoxidase Homo sapiens 25-40 2519707-1 1989 Amitrole (3-amino-1,2,4-triazole) meets the criteria for a suicide (mechanism-based) inhibitor of lactoperoxidase. Amitrole 0-8 lactoperoxidase Homo sapiens 98-113 2519707-1 1989 Amitrole (3-amino-1,2,4-triazole) meets the criteria for a suicide (mechanism-based) inhibitor of lactoperoxidase. Amitrole 10-32 lactoperoxidase Homo sapiens 98-113 2519707-2 1989 Amitrole causes rapid inactivation of lactoperoxidase only in the presence of hydrogen peroxide, and the kinetics are consistent with a suicide mechanism. Amitrole 0-8 lactoperoxidase Homo sapiens 38-53 2519707-3 1989 Approximately 7 mol of radiolabeled amitrole binds covalently per equivalent of lactoperoxidase activity lost. Amitrole 36-44 lactoperoxidase Homo sapiens 80-95 2519707-4 1989 The visible spectrum of lactoperoxidase inactivated by amitrole is unchanged, suggesting that covalent modification of the heme prosthetic group does not occur. Amitrole 55-63 lactoperoxidase Homo sapiens 24-39 229520-3 1979 These LPO-type enzymes, that are inhibited by cyanide and aminotriazole, appear to operate extracellularly as bactericidal agents in milk and in other biological fluids. Amitrole 58-71 lactoperoxidase Homo sapiens 6-9