PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide 127-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 22-37 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide 127-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-42 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. Ziprasidone Sulfoxide 127-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 254-257 10771452-7 2000 RESULTS: Three CYP-mediated metabolites - ziprasidone sulphoxide, ziprasidone sulphone and oxindole acetic acid - were identified. Ziprasidone Sulfoxide 42-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 15-18