PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19067706-0	2009	Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma.	Bexarotene	0-10	tumor protein p53	Homo sapiens	25-28	
19067706-13	2009	We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2.	Bexarotene	22-32	tumor protein p53	Homo sapiens	43-46	
19067706-13	2009	We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2.	Bexarotene	22-32	tumor protein p53	Homo sapiens	108-111	
19067706-13	2009	We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2.	Bexarotene	22-32	tumor protein p53	Homo sapiens	108-111	
19067706-14	2009	Bexarotene-mediated ataxia telangiectasia mutated protein (ATM) activation in all studied lines suggests that ATM is likely to be the p53/p73 upstream activator.	Bexarotene	0-10	tumor protein p53	Homo sapiens	134-137	
19067706-15	2009	CONCLUSIONS: Our data indicate for the first time that bexarotene exerts its effect in CTCL mainly by triggering the p53/p73-dependent cell cycle inhibition pathway, probably by upstream ATM activation.	Bexarotene	55-65	tumor protein p53	Homo sapiens	117-120	
23430755-6	2013	By double labeling of senescent cells, first by SA-beta-Gal and then by antibodies against genes related to cellular senescence, we found that p21, p16, and RARbeta, but not p53, were upregulated by bexarotene in mammary tumors and in breast cancer cell lines, suggesting involvement of multiple signaling pathways in mediating the senescence program of rexinoids.	Bexarotene	199-209	tumor protein p53	Homo sapiens	174-177