PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21636543-3 2011 Combining erlotinib and bexarotene, however, to cotarget cyclin D1 via the retinoid X receptor and EGFR was active preclinically in KRAS-driven lung cancer cells derived from transgenic mice and in two clinical studies in lung cancer (including wild-type EGFR tumors, with or without KRAS mutations), as reported in this issue of the journal by Dragnev and colleagues (beginning on page 818). Bexarotene 24-34 cyclin D1 Mus musculus 57-66 22431924-9 2012 Intestinal tumors of bexarotene-fed mice showed significantly reduced expression of proliferating cell nuclear antigen (60%, P < .0001), cyclin D1, and cyclooxygenase 2 and increased RXR-alpha messenger RNA and uptake of oleate (34%, P < .01). Bexarotene 21-31 cyclin D1 Mus musculus 140-149