PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30791908-0 2019 Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARgamma/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats. Bexarotene 37-47 sirtuin 6 Rattus norvegicus 91-96 30791908-11 2019 Mechanistically, bexarotene increased the levels of PPARgamma and SIRT6; decreased the expression of phosphorylated FoxO3a (p-FoxO3a), IL-6, IL-1beta, and TNF-a; and inhibited the microglia activation and neutrophils infiltration at 24 h after SAH. Bexarotene 17-27 sirtuin 6 Rattus norvegicus 66-71 30791908-12 2019 Either UVI3003, OSS128167, or RXR siRNA abolished the neuroprotective effects of bexarotene and its regulation on protein levels of PPARgamma/SIRT6/p-FoxO3a after SAH. Bexarotene 81-91 sirtuin 6 Rattus norvegicus 142-147