PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31998952-4 2020 In vivo and in vitro, IOP treatment caused renal damage and elevated the caspase-1 (+) PI (+) cell count, interleukin (IL)-1b and IL-18 levels, lactate dehydrogenase (LDH) release, and the relative expression of nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and gasdermin D (GSDMD), suggesting that IOP induces AKI via the activation of pyroptosis. iopromide 22-25 NLR family pyrin domain containing 3 Homo sapiens 281-286