PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15850715-4 2005 Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. Fatty Acids, Unsaturated 11-38 insulin Homo sapiens 107-114 15850715-4 2005 Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. Fatty Acids, Unsaturated 11-38 insulin Homo sapiens 145-152 15850715-4 2005 Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. Fatty Acids, Unsaturated 11-38 insulin Homo sapiens 145-152 15310732-1 2004 Dietary polyunsaturated fatty acids (PUFA) have effects on diverse physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune function, insulin action and neuronal development and visual function. Fatty Acids, Unsaturated 8-35 insulin Homo sapiens 220-227 15310732-1 2004 Dietary polyunsaturated fatty acids (PUFA) have effects on diverse physiological processes impacting normal health and chronic diseases, such as the regulation of plasma lipid levels, cardiovascular and immune function, insulin action and neuronal development and visual function. Fatty Acids, Unsaturated 37-41 insulin Homo sapiens 220-227 14729856-2 2004 Moreover, we estimated the diabetes risk and examined gene-nutrient interactions between these variants and the ratio of polyunsaturated fatty acid to saturated fat (SFA) in determining body mass index (BMI) and fasting insulin. Fatty Acids, Unsaturated 121-147 insulin Homo sapiens 220-227 12767456-2 2003 It is proposed that long-chain polyunsaturated fatty acids when given from the perinatal period will ensure proper development and growth of the brain and maintain the activity and/or concentrations of ras, nitric oxide, insulin, and various neurotransmitters and cytokines at physiological level and thus, improve memory and prevent learning deficits. Fatty Acids, Unsaturated 31-58 insulin Homo sapiens 221-228 12746754-12 2003 In their study, fasting glucose, insulin and fasting chylomicrons and postprandial chylomicrons and VLDL were higher following the PUFA diet. Fatty Acids, Unsaturated 131-135 insulin Homo sapiens 33-40 12037643-11 2002 Dietary fatty acids, particularly polyunsaturated fatty acids, are known to regulate adipocyte differentiation through the nuclear peroxisome proliferator-activated receptor gamma, and may also have a role in insulin resistance. Fatty Acids, Unsaturated 34-61 insulin Homo sapiens 209-216 11914740-0 2002 Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids. Fatty Acids, Unsaturated 110-136 insulin Homo sapiens 18-25 11914740-2 2002 In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. Fatty Acids, Unsaturated 63-90 insulin Homo sapiens 11-18 11914742-8 2002 Insulin sensitivity and plasma low density lipoprotein cholesterol concentrations improved with the diet rich in polyunsaturated fatty acids compared with the diet rich in saturated fatty acids. Fatty Acids, Unsaturated 113-140 insulin Homo sapiens 0-7 11118820-6 2000 Other proaging effects of insulin involve the inhibition of proteasome and the stimulation of polyunsaturated fatty acid (PUFA) synthesis and of nitric oxide (NO). Fatty Acids, Unsaturated 94-120 insulin Homo sapiens 26-33 11118820-6 2000 Other proaging effects of insulin involve the inhibition of proteasome and the stimulation of polyunsaturated fatty acid (PUFA) synthesis and of nitric oxide (NO). Fatty Acids, Unsaturated 122-126 insulin Homo sapiens 26-33 11063437-1 2000 BACKGROUND: Polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) have been shown to positively affect blood lipids; however, their comparative effects on insulin sensitivity are unclear. Fatty Acids, Unsaturated 41-46 insulin Homo sapiens 177-184 11149279-7 2000 As one important aspect if skeletal muscle has a high capacity for lipid oxidation, then more saturated fatty acids are oxidised and more unsaturated fatty acids are built in the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Fatty Acids, Unsaturated 138-161 insulin Homo sapiens 262-269 10776058-7 2000 An important aspect is that when skeletal muscle has a high capacity for lipid oxidation more saturated fatty acids are oxidized and more unsaturated fatty acids are built into the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Fatty Acids, Unsaturated 138-161 insulin Homo sapiens 264-271 10767564-1 2000 The purpose of this study was to evaluate the effectiveness and the toxicity of polyunsaturated fatty acid, such as oleic acid, eicosapentaenoic acid (DHA), as potential absorption enhancer for rectal delivery of insulin, using a water-in-oil-in water (W/O/W) multiple emulsion. Fatty Acids, Unsaturated 80-106 insulin Homo sapiens 213-220 10889793-0 2000 Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. Fatty Acids, Unsaturated 0-26 insulin Homo sapiens 103-110 10889809-1 2000 Insulin sensitivity is potentially enhanced by a range of diet-related changes including reduction of visceral adiposity, a reduction in saturated fatty acids, and possibly a redistribution of the proportions of various unsaturated fatty acids. Fatty Acids, Unsaturated 220-243 insulin Homo sapiens 0-7 9892230-1 1999 In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. Fatty Acids, Unsaturated 85-112 insulin Homo sapiens 17-24 9892230-1 1999 In adult humans, insulin resistance is associated with relatively low proportions of polyunsaturated fatty acids (PUFAs) in muscle membrane structural lipid. Fatty Acids, Unsaturated 114-119 insulin Homo sapiens 17-24 9892230-9 1999 The less unsaturated muscle membranes in children whose mothers have higher fasting insulin and triglyceride levels may reflect a genetic reluctance to incorporate PUFAs into membranes, thus predisposing them to insulin resistance syndromes. Fatty Acids, Unsaturated 164-169 insulin Homo sapiens 84-91 9892230-9 1999 The less unsaturated muscle membranes in children whose mothers have higher fasting insulin and triglyceride levels may reflect a genetic reluctance to incorporate PUFAs into membranes, thus predisposing them to insulin resistance syndromes. Fatty Acids, Unsaturated 164-169 insulin Homo sapiens 212-219 9483379-0 1997 Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro. Fatty Acids, Unsaturated 0-23 insulin Homo sapiens 34-41 9483379-9 1997 In conclusion, culture of islets of Langerhans for a week with high concentrations of unsaturated fatty acids produces a hypersecretion of insulin which is not influenced by secretagogues such as glucose, arginine, or forskolin. Fatty Acids, Unsaturated 86-109 insulin Homo sapiens 139-146 8729130-3 1996 Work in vitro and in vivo in both rats and humans has shown that incorporation of more unsaturated fatty acids into muscle membrane phospholipid is associated with improved insulin action. Fatty Acids, Unsaturated 87-110 insulin Homo sapiens 173-180 8729130-7 1996 In relation to fiber type, the more highly oxidative, insulin-sensitive type 1 and type 2a fibers have a higher percentage of unsaturated fatty acids, particularly n-3, in their membrane phospholipid, compared to the insulin-resistant, glycolytic, type 2b fibers. Fatty Acids, Unsaturated 126-149 insulin Homo sapiens 54-61 8675650-4 1995 Insulin action (high-dose clamp; MZ) correlated with composite measures of membrane unsaturation (% C20-22 polyunsaturated fatty acids [r= 0.463, P < 0.001], unsaturation index [r= -0.369, P < 0.01]), a number of individual fatty acids and with delta5 desaturase activity (r= 0.451, P < 0.001). Fatty Acids, Unsaturated 107-134 insulin Homo sapiens 0-7 8059770-6 1994 In addition, insulin levels were inversely associated with the intake of dietary fiber and polyunsaturated fatty acids, which could not be accounted for by variables such as energy intake, body mass index, physical activity, prescribed diets, or the presence of coronary heart disease. Fatty Acids, Unsaturated 91-118 insulin Homo sapiens 13-20 8022751-0 1994 Regulation of polyunsaturated fatty acid-stimulated insulin release by GIP in isolated perifused islets. Fatty Acids, Unsaturated 14-40 insulin Homo sapiens 52-59 8022751-2 1994 In the present study we examined, through the use of isolated perifused murine islets, the effect of GIP on insulin secretion that was stimulated by polyunsaturated fatty acids (PUFA) in the presence of low or high glucose concentrations. Fatty Acids, Unsaturated 149-176 insulin Homo sapiens 108-115 8290478-0 1993 Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems. Fatty Acids, Unsaturated 89-111 insulin Homo sapiens 68-75 8290478-4 1993 In this study, the effect of bile salt-unsaturated fatty acid mixed micelles on alpha-chymotryptic degradation of insulin was further characterized. Fatty Acids, Unsaturated 39-61 insulin Homo sapiens 114-121 8418404-8 1993 CONCLUSIONS: Decreased insulin sensitivity is associated with decreased concentrations of polyunsaturated fatty acids in skeletal-muscle phospholipids, raising the possibility that changes in the fatty-acid composition of muscles modulate the action of insulin. Fatty Acids, Unsaturated 90-117 insulin Homo sapiens 23-30 1843205-0 1991 Insulin sensitivity is increased in Friend erythroleukemia cells enriched in polyunsaturated fatty acid. Fatty Acids, Unsaturated 77-103 insulin Homo sapiens 0-7 1843205-6 1991 The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells. Fatty Acids, Unsaturated 32-58 insulin Homo sapiens 17-24 1843205-6 1991 The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells. Fatty Acids, Unsaturated 32-58 insulin Homo sapiens 125-132 1843205-6 1991 The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells. Fatty Acids, Unsaturated 32-58 insulin Homo sapiens 125-132 1843205-6 1991 The affinity for insulin in the polyunsaturated fatty acid treated cells decreased, however, resulting in similar amounts of insulin binding at low insulin concentrations but more binding at high insulin concentrations when compared to control cells. Fatty Acids, Unsaturated 32-58 insulin Homo sapiens 125-132 33774033-5 2021 Studies show that the consumption of polyunsaturated fatty acids (PUFAs) regulates menstrual cycle, decrease testosterone and insulin levels, and improve metabolic health. Fatty Acids, Unsaturated 37-64 insulin Homo sapiens 126-133 33774033-5 2021 Studies show that the consumption of polyunsaturated fatty acids (PUFAs) regulates menstrual cycle, decrease testosterone and insulin levels, and improve metabolic health. Fatty Acids, Unsaturated 66-71 insulin Homo sapiens 126-133 34732836-1 2022 BACKGROUND/OBJECTIVES: Oxylipins are polyunsaturated fatty acid derivatives involved in the regulation of various processes, including chronic inflammation, insulin resistance and hepatic steatosis. Fatty Acids, Unsaturated 37-63 insulin Homo sapiens 157-164 34801692-2 2022 Omega-3 polyunsaturated fatty acids (PUFAs) are key ingredients for maintaining cellular functions and improving insulin sensitivity. Fatty Acids, Unsaturated 37-42 insulin Homo sapiens 113-120 34346724-3 2021 This study complements the previous study by examining the effects of fasting duration and insulin infusion on circulating levels of oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids. Fatty Acids, Unsaturated 198-225 insulin Homo sapiens 91-98 34638763-6 2021 However, n-3 polyunsaturated fatty acids (PUFA) were decreased in the category with the highest C-peptide concentration (n-3 PUFA: CI -35.82--6.28, p < 0.006) and in the lowest ISHOMA category (n-3 PUFA: CI -36.48--5.61, p < 0.008). Fatty Acids, Unsaturated 42-46 insulin Homo sapiens 96-105 34825869-1 2021 The N-3 polyunsaturated fatty acids (PUFAs) have a wide range of health benefits, including anti-inflammatory effects, improvements in lipids metabolism and promoting insulin secretion, as well as reduction of cancer risk. Fatty Acids, Unsaturated 37-42 insulin Homo sapiens 167-174 34105707-1 2021 Polyunsaturated fatty acids help maintain insulin sensitivity, mitochondrial function, and anti-inflammation. Fatty Acids, Unsaturated 0-27 insulin Homo sapiens 42-49 35605891-5 2022 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated 79-106 insulin Homo sapiens 209-216 35605891-5 2022 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated 79-106 insulin Homo sapiens 232-239 35605891-5 2022 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated 108-113 insulin Homo sapiens 209-216 35605891-5 2022 Moreover, western blot and flow cytometry analysis showed that SNEs containing polyunsaturated fatty acids (PUFAs) increased phospo-AKT (p-AKT) expression, a marker for the stimulation of metabolic arm of the insulin signaling, and insulin uptake in human cerebral microvascular endothelial cell (hCMEC/D3) monolayers. Fatty Acids, Unsaturated 108-113 insulin Homo sapiens 232-239 35605891-7 2022 These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases. Fatty Acids, Unsaturated 61-66 insulin Homo sapiens 82-89 35605891-7 2022 These findings provided direct evidence that SNEs containing PUFAs can upregulate insulin-pAKT pathway, facilitate insulin trafficking at the BBB, and thereby address cerebrovascular dysfunction in metabolic and neurodegenerative diseases. Fatty Acids, Unsaturated 61-66 insulin Homo sapiens 115-122 6529855-2 1984 Improvement of diabetic control, achieved by treatment with continuous subcutaneous insulin infusion coincided with an increase of arachidonic acid and a normalization of total polyunsaturated fatty acids, with a concomitant decrease of total saturated fatty acids and total monounsaturated fatty acids, especially 18:1c, omega 9. Fatty Acids, Unsaturated 177-204 insulin Homo sapiens 84-91 6751393-4 1982 Insulin receptors were present in the normal cells at 180,000 sites/cell but this fell to 125000 (P less than 0.001) in cells enriched in monounsaturated fatty acids and rose to 386,000 (P less than 0.001) in cells enriched in polyunsaturated fatty acids. Fatty Acids, Unsaturated 227-254 insulin Homo sapiens 0-7 32008872-1 2020 BACKGROUND & AIMS: Omega-6 polyunsaturated fatty acids (PUFAs) have been shown to relate to insulin resistance and type 2 diabetes (T2D), but influence of race/ethnicity has not been investigated. Fatty Acids, Unsaturated 56-61 insulin Homo sapiens 92-99 32270281-0 2020 Associations of whole blood polyunsaturated fatty acids and insulin resistance among European children and adolescents. Fatty Acids, Unsaturated 28-55 insulin Homo sapiens 60-67 32270281-1 2020 This study aims to examine the association of whole blood n-3 and n-6 polyunsaturated fatty acids (PUFA) with insulin resistance (IR) in children. Fatty Acids, Unsaturated 99-103 insulin Homo sapiens 110-117 32290535-4 2020 Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein. Fatty Acids, Unsaturated 271-298 insulin Homo sapiens 107-114 31785494-3 2020 Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and specifically LA, and the improvement of cardiovascular risk (mainly of the plasma lipid profile), as well as long-term glycaemic control and insulin resistance. Fatty Acids, Unsaturated 130-134 insulin Homo sapiens 281-288 31691133-0 2020 Impact of a Formulation Containing Unusual Polyunsaturated Fatty Acids, Trace Elements, Polyphenols and Plant Sterols on Insulin Resistance and Associated Disturbances. Fatty Acids, Unsaturated 43-70 insulin Homo sapiens 121-128 31691133-1 2020 INTRODUCTION: To evaluate the effect of a lipid-based formulation containing unusual polyunsaturated fatty acids, trace elements, polyphenols and plant sterols on insulin resistance and its associated disturbances among adults at risk of diabetes. Fatty Acids, Unsaturated 85-112 insulin Homo sapiens 163-170 30708259-11 2019 The fast food-type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P < 0.05). Fatty Acids, Unsaturated 113-135 insulin Homo sapiens 167-174 29520627-1 2019 PURPOSE: Our aim was to evaluate the postprandial effect of an oral fat load test (OFLT) rich in unsaturated fatty acids on gene expression profile in peripheral blood mononuclear cells (PBMC) from subjects with abdominal obesity as an insulin resistance model and controls. Fatty Acids, Unsaturated 97-120 insulin Homo sapiens 236-243 31007954-8 2019 Moreover, the carriers of GG genotype with high polyunsaturated fatty acid intake (>=6% of TE/day) had significantly lower HOMA-IR (1.5 +- 0.3 vs 3.0 +- 0.7, p=0.026) and fasting insulin levels (6.8 +- 1.6 microU/mL vs 11.4 +- 2.1 microU/mL, p=0.036). Fatty Acids, Unsaturated 48-74 insulin Homo sapiens 182-189 30871233-14 2019 Our findings demonstrate that, in the context of a low-fat vegan diet, decreased intake of saturated and trans fats and increased relative content of polyunsaturated fatty acids, particularly linoleic and alpha-linolenic acids, are associated with decreased fat mass and insulin resistance, and enhanced insulin secretion. Fatty Acids, Unsaturated 150-177 insulin Homo sapiens 271-278 30899527-1 2019 The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. Fatty Acids, Unsaturated 84-111 insulin Homo sapiens 146-153 31984379-2 2019 We hypothesized that saturated fatty acid (SFA) intake, monounsaturated fatty acid (MUFA) and low intake of polyunsaturated fatty acids (PUFA) would be associated with markers of insulin resistance, hyperlipidemia, and hypertriglyceridemia. Fatty Acids, Unsaturated 108-135 insulin Homo sapiens 179-186 31984379-2 2019 We hypothesized that saturated fatty acid (SFA) intake, monounsaturated fatty acid (MUFA) and low intake of polyunsaturated fatty acids (PUFA) would be associated with markers of insulin resistance, hyperlipidemia, and hypertriglyceridemia. Fatty Acids, Unsaturated 137-141 insulin Homo sapiens 179-186 30453627-1 2018 Fatty acid desaturases (FADS) catalyze the formation of unsaturated fatty acids and have been related to insulin sensitivity (IS). Fatty Acids, Unsaturated 56-79 insulin Homo sapiens 105-112 29947780-11 2018 Conclusions: Targeted metabolomics identified four plasma amino acids and 16 plasma lipid species, primarily containing polyunsaturated fatty acids, that were associated with abnormal glucose metabolism and insulin resistance in older adults. Fatty Acids, Unsaturated 120-147 insulin Homo sapiens 207-214 29704509-6 2018 Thus it responds to endogenous medium and long chain unsaturated fatty acids, resulting in enhancement of insulin secretion during increased glucose levels. Fatty Acids, Unsaturated 53-76 insulin Homo sapiens 106-113 29546329-15 2018 Assessment of the hyperbolic relationship between insulin sensitivity and secretion through the disposition index revealed a distinctive signature of polyunsaturated fatty acids (P = 1.55 x 10-12 to 5.81 x 10-6; R2adj = 3.8%) beyond that of its component measures. Fatty Acids, Unsaturated 150-177 insulin Homo sapiens 50-57 29538286-6 2018 Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress. Fatty Acids, Unsaturated 16-43 insulin Homo sapiens 85-92 29538286-6 2018 Dietary omega 3 polyunsaturated fatty acids (PUFA) have been suggested to counteract insulin resistance development by modulating mitochondrial bioenergetics and ER stress. Fatty Acids, Unsaturated 45-49 insulin Homo sapiens 85-92 29466985-9 2018 Among those with insulin resistance there was a positive association between monounsaturated fatty acids and arachidonic fatty acid and adiponectin (p < 0.05), and a negative association between monounsaturated and polyunsaturated fatty acids and pro-inflammatory biomarkers (p < 0.05), as well as a negative association between polyunsaturated fatty acids and adiponectin (p < 0.05). Fatty Acids, Unsaturated 218-245 insulin Homo sapiens 17-24 29466985-11 2018 CONCLUSIONS: Subjects in secondary prevention for cardiovascular disease with insulin resistance have a higher concentration of hs-CRP and IL-6 than individuals without insulin resistance, and these inflammatory biomarkers are positively associated with saturated fatty acids and negatively associated with unsaturated fatty acids. Fatty Acids, Unsaturated 307-330 insulin Homo sapiens 78-85 29087622-10 2018 Polyunsaturated fatty acids and dietary fiber inversely correlate with insulin, HOMA-IR, and triglycerides. Fatty Acids, Unsaturated 0-27 insulin Homo sapiens 71-78 30615382-7 2017 To synthesize endogenous oleic mono unsaturated fatty acid the late in phylogenesis insulin expresses two enzymes of coupled biochemical reactions: palmitoyl-KoA-elongase andstearyl-KoA-desaturase, activating synthesis of fatty acids following the path glucose-endogenous palmitic unsaturated fatty acid-stearic unsaturated fatty acid-oleic mono unsaturated fatty acid. Fatty Acids, Unsaturated 281-304 insulin Homo sapiens 84-91 27484441-1 2017 BACKGROUND: Several studies have shown that omega-3 polyunsaturated fatty acids (PUFA) may improve insulin resistance in various diseases. Fatty Acids, Unsaturated 81-85 insulin Homo sapiens 99-106 27919543-1 2017 BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels. Fatty Acids, Unsaturated 30-56 insulin Homo sapiens 112-119 27919543-1 2017 BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels. Fatty Acids, Unsaturated 58-62 insulin Homo sapiens 112-119 27919543-10 2017 CONCLUSIONS: Higher maternal total n-3 PUFAs and specifically DHA levels during pregnancy are associated with higher childhood total-cholesterol, HDL-cholesterol and insulin levels. Fatty Acids, Unsaturated 39-44 insulin Homo sapiens 166-173 27184288-10 2016 Partially substituting UFA for carbohydrate has been associated with improved insulin sensitivity, lipoprotein lipids, and blood pressure. Fatty Acids, Unsaturated 23-26 insulin Homo sapiens 78-85 27313878-5 2016 Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert a beneficial effect by shifting Th1/Th2 balance to a Th2 phenotype and increasing insulin sensitivity. Fatty Acids, Unsaturated 45-50 insulin Homo sapiens 144-151 26925376-2 2015 The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects. Fatty Acids, Unsaturated 92-96 insulin Homo sapiens 134-141 24353137-8 2014 Total fatty acids and unsaturated fatty acids such as oleic acid and linoleic acid showed an inverse significant correlation with insulin resistance. Fatty Acids, Unsaturated 22-45 insulin Homo sapiens 130-137 24353137-9 2014 Children with high insulin resistance (HOMA-IR >2.5) showed a decrease in unsaturated fatty acids compared with children having a HOMA-IR of <2.5. Fatty Acids, Unsaturated 77-100 insulin Homo sapiens 19-26 24353137-11 2014 CONCLUSIONS: A decrease in unsaturated fatty acids was correlated with insulin resistance in childhood obesity. Fatty Acids, Unsaturated 27-50 insulin Homo sapiens 71-78 24632852-9 2014 CONCLUSIONS/INTERPRETATION: Beneficial gains in insulin sensitivity and the ability of unsaturated fatty acids to oppose palmitate-induced insulin resistance in muscle cells may partly be accounted for by counter-modulation of PP2A. Fatty Acids, Unsaturated 87-110 insulin Homo sapiens 139-146 24211519-2 2014 The results showed that Akt phosphorylation was increased in SK-Hep-1 cells treated with insulin in a time- and concentration-dependent manner, which was inhibited by saturated fatty acids, but not by unsaturated fatty acids. Fatty Acids, Unsaturated 201-224 insulin Homo sapiens 89-96 24195588-0 2013 LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. Fatty Acids, Unsaturated 28-55 insulin Homo sapiens 90-97 23820633-1 2013 AIMS/HYPOTHESIS: Previous studies have shown that saturated fatty acids cause insulin resistance (IR) that is prevented by unsaturated fatty acids. Fatty Acids, Unsaturated 123-146 insulin Homo sapiens 78-85 23438101-3 2013 OBJECTIVE: To assess the effect of metformin (Met) or omega-3 (omega-3) polyunsaturated fatty acids (PUFA) on the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, lipid profile, and body mass index (BMI) of obese children. Fatty Acids, Unsaturated 101-105 insulin Homo sapiens 153-160 23826284-0 2013 Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance. Fatty Acids, Unsaturated 0-27 insulin Homo sapiens 96-103 23039070-1 2012 The aim was to determine the relative role of each of the lactogenic hormones (insulin, prolactin and hydrocortisol) and their combinations in regulating elongation and desaturation of polyunsaturated fatty acids and subsequently on composition of cellular lipid compartments in mammary epithelia. Fatty Acids, Unsaturated 185-212 insulin Homo sapiens 79-86 22314192-5 2012 Various treatments successful at improving insulin response (thiazolidinediones (TZDs), n-3 polyunsaturated fatty acid (PUFA) supplementation) also stimulate adiponectin production. Fatty Acids, Unsaturated 120-124 insulin Homo sapiens 43-50 22338035-0 2012 PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity. Fatty Acids, Unsaturated 0-5 insulin Homo sapiens 105-112 22338035-11 2012 CONCLUSION: PUFAs reduced triacylglycerol-derived skeletal muscle FA uptake, which was accompanied by higher postprandial insulin sensitivity, a more transcriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be protective against the development of insulin resistance. Fatty Acids, Unsaturated 12-17 insulin Homo sapiens 122-129 22338035-11 2012 CONCLUSION: PUFAs reduced triacylglycerol-derived skeletal muscle FA uptake, which was accompanied by higher postprandial insulin sensitivity, a more transcriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be protective against the development of insulin resistance. Fatty Acids, Unsaturated 12-17 insulin Homo sapiens 294-301 22371399-6 2012 Polyunsaturated fatty acids supplied in the diet did affect the development of insulin-sensitive tissues during both the fetal and postnatal period. Fatty Acids, Unsaturated 0-27 insulin Homo sapiens 79-86 21570480-11 2011 PUFAs promote pathways, at a transcriptional level, that increase fat oxidation and synergize with factors from SC fat to abrogate PA-induced insulin resistance. Fatty Acids, Unsaturated 0-5 insulin Homo sapiens 142-149 21413848-1 2011 Increasing evidence suggests that fatty acid desaturases, rate-limiting enzymes in unsaturated fatty acid biosynthesis, are important factors in the pathogenesis of lipid-induced insulin resistance. Fatty Acids, Unsaturated 83-105 insulin Homo sapiens 179-186 21513558-1 2011 BACKGROUND: We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. Fatty Acids, Unsaturated 168-194 insulin Homo sapiens 105-112 20694299-1 2010 INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA). Fatty Acids, Unsaturated 199-226 insulin Homo sapiens 139-146 20694299-1 2010 INTRODUCTION: The peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) is an adipogenic transcription factor that influences in insulin resistance (IR) in the presence of agonists such as polyunsaturated fatty acids (PUFA). Fatty Acids, Unsaturated 228-232 insulin Homo sapiens 139-146 19998382-1 2010 Increased tissue n-3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes. Fatty Acids, Unsaturated 49-53 insulin Homo sapiens 83-90 20388132-4 2010 We review results demonstrating how the balance between different classes of carbohydrates and proteins modulates the obesigenic action of saturated as well as unsaturated fatty acids pointing to insulin as a key determinant in the regulation of the metabolic/regulatory action of both n-3 and n-6 polyunsaturated fatty acids. Fatty Acids, Unsaturated 160-183 insulin Homo sapiens 196-203 19908022-2 2010 Generally, lipotoxicity is triggered by saturated fatty acids, whereas unsaturated fatty acids induce lipodysfunction, the latter being characterised by elevated basal insulin release and impaired glucose responses. Fatty Acids, Unsaturated 71-94 insulin Homo sapiens 168-175 20032477-0 2010 Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults. Fatty Acids, Unsaturated 44-71 insulin Homo sapiens 91-98 19675375-7 2009 Data suggest that dietary omega-3 polyunsaturated fatty acids (PUFAs) improve lipid profile and may have beneficial effect on insulin resistance. Fatty Acids, Unsaturated 63-68 insulin Homo sapiens 126-133 19202385-1 2009 PURPOSE OF REVIEW: Review results from recent human and animal studies regarding the effects of n-3 polyunsaturated fatty acid (PUFA) in the prevention of insulin resistance. Fatty Acids, Unsaturated 128-132 insulin Homo sapiens 155-162 18442502-8 2008 CONCLUSIONS: Polyunsaturated fatty acid and simple carbohydrates may be associated with MSDR and insulin resistance in American Indians and sex may modify the association between dietary intake and MS and insulin resistance in this population. Fatty Acids, Unsaturated 13-39 insulin Homo sapiens 97-104 18442502-8 2008 CONCLUSIONS: Polyunsaturated fatty acid and simple carbohydrates may be associated with MSDR and insulin resistance in American Indians and sex may modify the association between dietary intake and MS and insulin resistance in this population. Fatty Acids, Unsaturated 13-39 insulin Homo sapiens 205-212 18442503-0 2008 Reduce simple carbohydrate and animal protein intake and increase polyunsaturated fatty acid intake in patients with metabolic syndrome and insulin resistance. Fatty Acids, Unsaturated 66-92 insulin Homo sapiens 140-147 17878672-2 2007 Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown. Fatty Acids, Unsaturated 58-62 insulin Homo sapiens 71-78 17158408-2 2006 It has been hypothesized that the dietary ratio of n-6 to n-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) may have favorable effects on these risk factors by increasing insulin sensitivity. Fatty Acids, Unsaturated 72-99 insulin Homo sapiens 171-178 16910164-11 2006 In contrast, polyunsaturated fatty acids increase plasma insulin concentration and decrease insulin resistance. Fatty Acids, Unsaturated 13-40 insulin Homo sapiens 57-64 16910164-11 2006 In contrast, polyunsaturated fatty acids increase plasma insulin concentration and decrease insulin resistance. Fatty Acids, Unsaturated 13-40 insulin Homo sapiens 92-99 16319806-6 2005 Higher levels of membrane saturated fatty acids seem to greatly impair the action of insulin, whereas the presence of polyunsaturated fatty acids, especially of the omega-3 and -6 families, in contrast, improves insulin sensitivity. Fatty Acids, Unsaturated 118-145 insulin Homo sapiens 212-219