PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 5-lipoxygenase	Homo sapiens	10-24	
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 5-lipoxygenase	Homo sapiens	0-14	
31871543-1	2019	5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid.	Fatty Acids, Unsaturated	104-131	arachidonate 5-lipoxygenase	Homo sapiens	16-21	
24893149-1	2014	5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid.	Fatty Acids, Unsaturated	223-249	arachidonate 5-lipoxygenase	Homo sapiens	0-14	
24893149-1	2014	5-Lipoxygenase (5-LOX) reacts with arachidonic acid (AA) to first generate 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid [5(S)-HpETE] and then an epoxide from 5(S)-HpETE to form leukotriene A4, from a single polyunsaturated fatty acid.	Fatty Acids, Unsaturated	223-249	arachidonate 5-lipoxygenase	Homo sapiens	16-21	
28986132-3	2018	Inflammation resolution is an active process controlled by lipidic specialized pro-resolving mediators (SPMs), derived from omega-3 or omega-6 essential polyunsaturated fatty acids (PUFA) through the activity of lipoxygenases (ALOX5 and 15).	Fatty Acids, Unsaturated	182-186	arachidonate 5-lipoxygenase	Homo sapiens	227-232	
15572846-8	2004	Since the 5-lipoxygenase pathway is abundantly expressed in atherosclerotic lesions, and 12/15-lipoxygenase is able to oxygenate polyunsaturated fatty acid esterified in the membranous phospholipids, 5-lipoxygenase or 12/15-lipoxygenase inhibitors may prevent progression of atherosclerosis.	Fatty Acids, Unsaturated	129-155	arachidonate 5-lipoxygenase	Homo sapiens	93-107	
2653575-1	1989	The 5-lipoxygenase pathway for the oxidative metabolism of unsaturated fatty acids was first recognized less than 10 years ago with the definition of 5-S hydroxy eicosatetraenoic acid (5-HETE) as a product, and its potential biological relevance to inflammation was suggested solely by the modest chemotactic activity of this compound.	Fatty Acids, Unsaturated	59-82	arachidonate 5-lipoxygenase	Homo sapiens	4-18	
9630716-5	1998	In conclusion, this study demonstrates that a recombinant human FLAP can stimulate a lipoxygenase other than mammalian 5-lipoxygenase (S.t.LOX) by using different polyunsaturated fatty acids as substrates.	Fatty Acids, Unsaturated	163-190	arachidonate 5-lipoxygenase	Homo sapiens	119-133	
8631361-10	1996	The results show that the inactivation of 5-lipoxygenase in phospholipid vesicles is dependent on the structure of the unsaturated fatty acid substrate for the reaction, on the concentration of oxygen and on a turnover-independent oxidation at the active-site leading to the sequential loss of the oxygenase and pseudoperoxidase activities of the enzyme.	Fatty Acids, Unsaturated	119-141	arachidonate 5-lipoxygenase	Homo sapiens	42-56	
1659156-2	1991	Enzymatic transformation of the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid (AA) by the 5-lipoxygenase (LO) enzyme results in the formation of leukotrienes (LTs) including leukotriene B4 (LTB4), which is a potent mediator of inflammation.	Fatty Acids, Unsaturated	64-68	arachidonate 5-lipoxygenase	Homo sapiens	99-113	
25290781-1	1985	The leukotrienes are a group of biologically active molecules derived from the oxidative metabolism of unsaturated fatty acids via the 5-lipoxygenase pathway.	Fatty Acids, Unsaturated	103-126	arachidonate 5-lipoxygenase	Homo sapiens	135-149